Electrical microstimulation of cortical area MST biases heading perception in monkeys.

Abstract:

:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiological observations on the motion-sensitive areas of monkey visual cortex suggest that the medial superior temporal area (MST) is well suited for the analysis of optic flow information. To test whether MST is involved in extracting heading from optic flow, we perturbed its activity in monkeys trained on a heading discrimination task. Electrical microstimulation of MST frequently biased the monkeys' decisions about their heading, and these induced biases were often quite large. This result suggests that MST has a direct role in the perception of heading from optic flow.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Britten KH,van Wezel RJ

doi

10.1038/259

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

59-63

issue

1

eissn

1097-6256

issn

1546-1726

journal_volume

1

pub_type

杂志文章
  • Ribbon synapses compute temporal contrast and encode luminance in retinal rod bipolar cells.

    abstract::Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2945

    authors: Oesch NW,Diamond JS

    更新日期:2011-10-23 00:00:00

  • Skeletal myogenic potential of human and mouse neural stem cells.

    abstract::Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/79924

    authors: Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

    更新日期:2000-10-01 00:00:00

  • Molecular disruption of hypothalamic nutrient sensing induces obesity.

    abstract::The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1626

    authors: He W,Lam TK,Obici S,Rossetti L

    更新日期:2006-02-01 00:00:00

  • Cortical specialization for attended versus unattended working memory.

    abstract::Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0094-4

    authors: Christophel TB,Iamshchinina P,Yan C,Allefeld C,Haynes JD

    更新日期:2018-04-01 00:00:00

  • Columnar organization of spatial phase in visual cortex.

    abstract::Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3878

    authors: Wang Y,Jin J,Kremkow J,Lashgari R,Komban SJ,Alonso JM

    更新日期:2015-01-01 00:00:00

  • CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits.

    abstract::Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element-binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormalities were reversed...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2257

    authors: Wallace DL,Han MH,Graham DL,Green TA,Vialou V,Iñiguez SD,Cao JL,Kirk A,Chakravarty S,Kumar A,Krishnan V,Neve RL,Cooper DC,Bolaños CA,Barrot M,McClung CA,Nestler EJ

    更新日期:2009-02-01 00:00:00

  • Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.

    abstract::Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expression changes withi...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-020-0621-y

    authors: Nagy C,Maitra M,Tanti A,Suderman M,Théroux JF,Davoli MA,Perlman K,Yerko V,Wang YC,Tripathy SJ,Pavlidis P,Mechawar N,Ragoussis J,Turecki G

    更新日期:2020-06-01 00:00:00

  • Neural computations of threat in the aftermath of combat trauma.

    abstract::By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0315-x

    authors: Homan P,Levy I,Feltham E,Gordon C,Hu J,Li J,Pietrzak RH,Southwick S,Krystal JH,Harpaz-Rotem I,Schiller D

    更新日期:2019-03-01 00:00:00

  • Rapid turnover of actin in dendritic spines and its regulation by activity.

    abstract::Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn811

    authors: Star EN,Kwiatkowski DJ,Murthy VN

    更新日期:2002-03-01 00:00:00

  • Neurobiology of resilience.

    abstract::Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/nn.3234

    authors: Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

    更新日期:2012-11-01 00:00:00

  • Reward and motivation in pain and pain relief.

    abstract::Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...

    journal_title:Nature neuroscience

    pub_type: 杂志文章,评审

    doi:10.1038/nn.3811

    authors: Navratilova E,Porreca F

    更新日期:2014-10-01 00:00:00

  • Contrast gain control and cortical TrkB signaling shape visual acuity.

    abstract::During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2534

    authors: Heimel JA,Saiepour MH,Chakravarthy S,Hermans JM,Levelt CN

    更新日期:2010-05-01 00:00:00

  • A developmental switch in the signaling cascades for LTP induction.

    abstract::Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn985

    authors: Yasuda H,Barth AL,Stellwagen D,Malenka RC

    更新日期:2003-01-01 00:00:00

  • Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors.

    abstract::Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2862

    authors: Bello EP,Mateo Y,Gelman DM,Noaín D,Shin JH,Low MJ,Alvarez VA,Lovinger DM,Rubinstein M

    更新日期:2011-07-10 00:00:00

  • LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity.

    abstract::Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3636

    authors: Parisiadou L,Yu J,Sgobio C,Xie C,Liu G,Sun L,Gu XL,Lin X,Crowley NA,Lovinger DM,Cai H

    更新日期:2014-03-01 00:00:00

  • Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice.

    abstract::Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-017-0004-1

    authors: Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

    更新日期:2017-12-01 00:00:00

  • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons.

    abstract::Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/4553

    authors: Williamson TL,Cleveland DW

    更新日期:1999-01-01 00:00:00

  • A sugar transporter as a candidate for the outer hair cell motor.

    abstract::Forces developed by cochlear outer hair cells (OHCs) are responsible for the sharp tuning that underlies sensitivity and frequency selectivity in the ear. OHCs exhibit a voltage-dependent motility involving a 'motor' protein embedded in the basolateral membrane. The motor has so far resisted molecular identification. ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/11174

    authors: Géléoc GS,Casalotti SO,Forge A,Ashmore JF

    更新日期:1999-08-01 00:00:00

  • Variable channel expression in identified single and electrically coupled neurons in different animals.

    abstract::It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1639

    authors: Schulz DJ,Goaillard JM,Marder E

    更新日期:2006-03-01 00:00:00

  • Regulation of T-type calcium channels by Rho-associated kinase.

    abstract::We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1921

    authors: Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

    更新日期:2007-07-01 00:00:00

  • Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation.

    abstract::Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/71090

    authors: Choi YB,Tenneti L,Le DA,Ortiz J,Bai G,Chen HS,Lipton SA

    更新日期:2000-01-01 00:00:00

  • Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.

    abstract::Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.2751

    authors: Murray AJ,Sauer JF,Riedel G,McClure C,Ansel L,Cheyne L,Bartos M,Wisden W,Wulff P

    更新日期:2011-03-01 00:00:00

  • Motility-associated hair-bundle motion in mammalian outer hair cells.

    abstract::Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn1509

    authors: Jia S,He DZ

    更新日期:2005-08-01 00:00:00

  • Functional imaging of the primate superior colliculus during saccades to visual targets.

    abstract::The primate superior colliculus (SC) is a midbrain nucleus crucial for the control of rapid eye movements (saccades). Its neurons are topographically arranged over the rostrocaudal and mediolateral extent of its deeper layers so that saccade metrics (amplitude and direction) are coded in terms of the location of activ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn727

    authors: Moschovakis AK,Gregoriou GG,Savaki HE

    更新日期:2001-10-01 00:00:00

  • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.

    abstract::Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn835

    authors: Hardingham GE,Fukunaga Y,Bading H

    更新日期:2002-05-01 00:00:00

  • Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use.

    abstract::A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3369

    authors: Bock R,Shin JH,Kaplan AR,Dobi A,Markey E,Kramer PF,Gremel CM,Christensen CH,Adrover MF,Alvarez VA

    更新日期:2013-05-01 00:00:00

  • Broadly tuned and respiration-independent inhibition in the olfactory bulb of awake mice.

    abstract::Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/nn.3669

    authors: Cazakoff BN,Lau BY,Crump KL,Demmer HS,Shea SD

    更新日期:2014-04-01 00:00:00

  • Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.

    abstract::Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional cross...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-020-00788-z

    authors: Paredes I,Vieira JR,Shah B,Ramunno CF,Dyckow J,Adler H,Richter M,Schermann G,Giannakouri E,Schirmer L,Augustin HG,Ruiz de Almodóvar C

    更新日期:2021-01-28 00:00:00

  • SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.

    abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/5715

    authors: Iadecola C,Zhang F,Niwa K,Eckman C,Turner SK,Fischer E,Younkin S,Borchelt DR,Hsiao KK,Carlson GA

    更新日期:1999-02-01 00:00:00

  • State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex.

    abstract::In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...

    journal_title:Nature neuroscience

    pub_type: 杂志文章

    doi:10.1038/s41593-018-0317-8

    authors: Elgueda D,Duque D,Radtke-Schuller S,Yin P,David SV,Shamma SA,Fritz JB

    更新日期:2019-03-01 00:00:00