Abstract：
:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We report here that, unlike LTP in the more mature CA1 region of the hippocampus, LTP in neonatal rodent hippocampus (<9 postnatal days, journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-018-0235-9
更新日期：2018-10-01 00:00:00
abstract：:Anatomical studies have led to the assertion that intratelencephalic and pyramidal tract cortical neurons innervate different striatal projection neurons. To test this hypothesis, we measured the responses of mouse striatal neurons to optogenetic activation of intratelencephalic and pyramidal tract axons. Contrary to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3397
更新日期：2013-06-01 00:00:00
abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3598
更新日期：2014-01-01 00:00:00
abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0075-7
更新日期：2018-03-01 00:00:00
abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1850
更新日期：2007-03-01 00:00:00
abstract：:The development of neuronal networks in the neocortex depends on control mechanisms for mitosis and migration that allow newborn neurons to find their accurate position. Multiple mitogens, neurotrophic factors, guidance molecules and their corresponding receptors are involved in this process, but the mechanisms by whi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3333
更新日期：2013-04-01 00:00:00
abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/688
更新日期：1998-07-01 00:00:00
abstract：:In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2005
更新日期：2007-12-01 00:00:00
abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1056
更新日期：2003-06-01 00:00:00
abstract：:Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1734
更新日期：2006-08-01 00:00:00
abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1338
更新日期：2004-11-01 00:00:00
abstract：:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1679
更新日期：2006-05-01 00:00:00
abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-017-0020-1
更新日期：2017-12-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
abstract：:Glycine receptors (GlyRs), together with GABA(A) and nicotinic acetylcholine (ACh) receptors, form part of the ligand-activated ion channel superfamily and regulate the excitability of the mammalian brain stem and spinal cord. Here we report that the ability of the neurotransmitter glycine to gate recombinant and nati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1095
更新日期：2003-08-01 00:00:00
abstract：:Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3625
更新日期：2014-02-01 00:00:00
abstract：:Microcircuits composed of principal neuron and interneuron dendrites have an important role in shaping the representation of sensory information in the olfactory bulb. Here we establish the physiological features governing synaptic signaling in dendrodendritic microcircuits of olfactory bulb glomeruli. We show that de...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1403
更新日期：2005-03-01 00:00:00
abstract：:The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4171
更新日期：2015-12-01 00:00:00
abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2332
更新日期：2009-06-01 00:00:00
abstract：:We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3843
更新日期：2014-12-01 00:00:00
abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4116
更新日期：2015-11-01 00:00:00
abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1626
更新日期：2006-02-01 00:00:00
abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4442
更新日期：2017-01-01 00:00:00
abstract：:The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligoden...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4425
更新日期：2017-01-01 00:00:00
abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn871
更新日期：2002-07-01 00:00:00
abstract：:The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn892
更新日期：2002-08-01 00:00:00
abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn2054
更新日期：2008-03-01 00:00:00
abstract：:Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn1206-1463
更新日期：2006-12-01 00:00:00
abstract：:The processing of synaptic potentials by neuronal dendrites depends on both their passive cable properties and active voltage-gated channels, which can generate complex effects as a result of their nonlinear properties. We characterized the actions of HCN (hyperpolarization-activated cyclic nucleotide-gated cation) ch...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2307
更新日期：2009-05-01 00:00:00
abstract：:Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record b...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3905
更新日期：2015-02-01 00:00:00
