Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice.

abstract：:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

journal_title：Nature neuroscience

authors： Lee HK,Min SS,Gallagher M,Kirkwood A

更新日期：2005-12-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...

journal_title：Nature neuroscience

authors： Tran SS,Jun HI,Bahn JH,Azghadi A,Ramaswami G,Van Nostrand EL,Nguyen TB,Hsiao YE,Lee C,Pratt GA,Martínez-Cerdeño V,Hagerman RJ,Yeo GW,Geschwind DH,Xiao X

更新日期：2019-01-01 00:00:00

abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

journal_title：Nature neuroscience

authors： Wan X,Cheng K,Tanaka K

更新日期：2015-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...

journal_title：Nature neuroscience

authors： Chesi A,Staahl BT,Jovičić A,Couthouis J,Fasolino M,Raphael AR,Yamazaki T,Elias L,Polak M,Kelly C,Williams KL,Fifita JA,Maragakis NJ,Nicholson GA,King OD,Reed R,Crabtree GR,Blair IP,Glass JD,Gitler AD

更新日期：2013-07-01 00:00:00

abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...

journal_title：Nature neuroscience

authors： Stoodley CJ,D'Mello AM,Ellegood J,Jakkamsetti V,Liu P,Nebel MB,Gibson JM,Kelly E,Meng F,Cano CA,Pascual JM,Mostofsky SH,Lerch JP,Tsai PT

更新日期：2017-12-01 00:00:00

abstract：:Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...

journal_title：Nature neuroscience

authors： Williams SR

更新日期：2004-09-01 00:00:00

abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...

journal_title：Nature neuroscience

authors： Sheth BR,Nijhawan R,Shimojo S

更新日期：2000-05-01 00:00:00

abstract：:Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...

journal_title：Nature neuroscience

authors： Demontis D,Rajagopal VM,Thorgeirsson TE,Als TD,Grove J,Leppälä K,Gudbjartsson DF,Pallesen J,Hjorthøj C,Reginsson GW,Tyrfingsson T,Runarsdottir V,Qvist P,Christensen JH,Bybjerg-Grauholm J,Bækvad-Hansen M,Huckins LM,Stahl

更新日期：2019-07-01 00:00:00

abstract：:GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...

journal_title：Nature neuroscience

authors： Mederos S,Sánchez-Puelles C,Esparza J,Valero M,Ponomarenko A,Perea G

更新日期：2021-01-01 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expression changes withi...

journal_title：Nature neuroscience

authors： Nagy C,Maitra M,Tanti A,Suderman M,Théroux JF,Davoli MA,Perlman K,Yerko V,Wang YC,Tripathy SJ,Pavlidis P,Mechawar N,Ragoussis J,Turecki G

更新日期：2020-06-01 00:00:00

abstract：:The ventral intraparietal area (VIP) receives converging inputs from visual, somatosensory, auditory and vestibular systems that use diverse reference frames to encode sensory information. A key issue is how VIP combines those inputs together. We mapped the visual and tactile receptive fields of multimodal VIP neurons...

journal_title：Nature neuroscience

authors： Avillac M,Denève S,Olivier E,Pouget A,Duhamel JR

更新日期：2005-07-01 00:00:00

abstract：:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...

journal_title：Nature neuroscience

authors： Bibel M,Richter J,Schrenk K,Tucker KL,Staiger V,Korte M,Goetz M,Barde YA

更新日期：2004-09-01 00:00:00

abstract：:Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...

journal_title：Nature neuroscience

authors： Knuckles P,Vogt MA,Lugert S,Milo M,Chong MM,Hautbergue GM,Wilson SA,Littman DR,Taylor V

更新日期：2012-06-17 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...

journal_title：Nature neuroscience

authors： Kandler K,Clause A,Noh J

更新日期：2009-06-01 00:00:00

abstract：:Axon guidance cues contributing to the development of eye-specific visual projections to the lateral geniculate nucleus (LGN) have not previously been identified. Here we show that gradients of ephrin-As and their receptors (EphAs) direct retinal ganglion cell (RGC) axons from the two eyes into their stereotyped patte...

journal_title：Nature neuroscience

authors： Huberman AD,Murray KD,Warland DK,Feldheim DA,Chapman B

更新日期：2005-08-01 00:00:00

abstract：:In the cat primary visual cortex, neurons are classified into the two main categories of simple cells and complex cells based on their response properties. According to the hierarchical model, complex receptive fields derive from convergent inputs of simple cells with similar orientation preferences. This model receiv...

journal_title：Nature neuroscience

authors： Alonso JM,Martinez LM

更新日期：1998-09-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...

journal_title：Nature neuroscience

authors： Tomizawa K,Iga N,Lu YF,Moriwaki A,Matsushita M,Li ST,Miyamoto O,Itano T,Matsui H

更新日期：2003-04-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...

journal_title：Nature neuroscience

authors： Parisiadou L,Yu J,Sgobio C,Xie C,Liu G,Sun L,Gu XL,Lin X,Crowley NA,Lovinger DM,Cai H

更新日期：2014-03-01 00:00:00

abstract：:Neural activity in visual area V4 is enhanced when attention is directed into neuronal receptive fields. However, the source of this enhancement is unclear, as most physiological studies have manipulated attention by changing the absolute reward associated with a particular location as well as its value relative to ot...

journal_title：Nature neuroscience

authors： Baruni JK,Lau B,Salzman CD

更新日期：2015-11-01 00:00:00

abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

journal_title：Nature neuroscience

authors： Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

更新日期：2015-02-01 00:00:00

abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...

journal_title：Nature neuroscience

authors： Carvalho RF,Beutler M,Marler KJ,Knöll B,Becker-Barroso E,Heintzmann R,Ng T,Drescher U

更新日期：2006-03-01 00:00:00

abstract：:Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal r...

journal_title：Nature neuroscience

authors： Lorber B,Howe ML,Benowitz LI,Irwin N

更新日期：2009-11-01 00:00:00

abstract：:Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...

journal_title：Nature neuroscience

authors： van Praag H,Kempermann G,Gage FH

更新日期：1999-03-01 00:00:00

abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...

journal_title：Nature neuroscience

authors： Tan GH,Liu YY,Hu XL,Yin DM,Mei L,Xiong ZQ

更新日期：2011-12-11 00:00:00

abstract：:Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is unique to resilience. Zfp189, which encodes a previously unstudied zin...

journal_title：Nature neuroscience

authors： Lorsch ZS,Hamilton PJ,Ramakrishnan A,Parise EM,Salery M,Wright WJ,Lepack AE,Mews P,Issler O,McKenzie A,Zhou X,Parise LF,Pirpinias ST,Ortiz Torres I,Kronman HG,Montgomery SE,Loh YE,Labonté B,Conkey A,Symonds AE,Nev

更新日期：2019-09-01 00:00:00

abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...

journal_title：Nature neuroscience

authors： Cavanagh P,Hénaff MA,Michel F,Landis T,Troscianko T,Intriligator J

更新日期：1998-07-01 00:00:00