Abstract:
:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Lee HK,Min SS,Gallagher M,Kirkwood Adoi
10.1038/nn1586subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1657-9issue
12eissn
1097-6256issn
1546-1726pii
nn1586journal_volume
8pub_type
杂志文章abstract::Fear-inducing memories can be state dependent, meaning that they can best be retrieved if the brain states at encoding and retrieval are similar. Restricted access to such memories can present a risk for psychiatric disorders and hamper their treatment. To better understand the mechanisms underlying state-dependent fe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4084
更新日期:2015-09-01 00:00:00
abstract::The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2218
更新日期:2008-12-01 00:00:00
abstract::Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1126
更新日期:2003-10-01 00:00:00
abstract::Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1150
更新日期:2003-12-01 00:00:00
abstract::Communication between glia cells and neurons is crucial for brain functions, but the molecular mechanisms and functional consequences of gliotransmission remain enigmatic. Here we report that astrocytes express synaptobrevin II and cellubrevin as functionally non-overlapping vesicular SNARE proteins on glutamatergic v...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4647
更新日期:2017-11-01 00:00:00
abstract::Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1305
更新日期:2004-09-01 00:00:00
abstract::Retinal bipolar cells have been assumed to generate purely graded responses to light. To test this idea we imaged the presynaptic calcium transient in live zebrafish. We found that ON, OFF, transient and sustained bipolar cells are all capable of generating fast 'all-or-none' calcium transients modulated by visual sti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2841
更新日期:2011-06-26 00:00:00
abstract::The C. elegans SAX-3/Robo receptor acts in anterior-posterior, dorsal-ventral and midline guidance decisions. Here we show that SAX-3 signaling involves the C. elegans Enabled protein UNC-34 and an unexpected Netrin-independent function of the Netrin receptor UNC-40/DCC. Genetic interactions with gain- and loss-of-fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn956
更新日期:2002-11-01 00:00:00
abstract::Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3862
更新日期:2014-12-01 00:00:00
abstract::Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/6368
更新日期:1999-03-01 00:00:00
abstract::Chronic morphine exposure upregulates adenylate cyclase signaling and reduces analgesic efficacy, a condition known as opioid tolerance. Nonopioid neurotransmitters can enhance morphine tolerance, but the mechanism for this is poorly understood. We show that morphine tolerance was delayed in mice lacking vasopressin 1...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0144-y
更新日期:2018-06-01 00:00:00
abstract::Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn1581
更新日期:2005-11-01 00:00:00
abstract::Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nuc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1949
更新日期:2007-09-01 00:00:00
abstract::The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1933
更新日期:2007-08-01 00:00:00
abstract::Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/nn1616
更新日期:2006-01-01 00:00:00
abstract::Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/13149
更新日期:1999-10-01 00:00:00
abstract::Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin. ...
journal_title:Nature neuroscience
pub_type: 评论,杂志文章,评审
doi:10.1038/85042
更新日期:2001-03-01 00:00:00
abstract::The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2826
更新日期:2011-06-01 00:00:00
abstract::Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3999
更新日期:2015-05-01 00:00:00
abstract::We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1780
更新日期:2006-11-01 00:00:00
abstract::Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3717
更新日期:2014-06-01 00:00:00
abstract::At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1450
更新日期:2005-05-01 00:00:00
abstract::Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4442
更新日期:2017-01-01 00:00:00
abstract::The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4186
更新日期:2016-01-01 00:00:00
abstract::Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer collateral inputs and postsynaptic firing is associated with localized increases in synaptic strength and dendritic excitability. Using the same protocol, we now demonstrate a decrease in cellular excitability that was blocked by the h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1568
更新日期:2005-11-01 00:00:00
abstract::Transformation of mechanical energy into ionic currents is essential for touch, hearing and nociception. Although DEG/ENaC proteins are believed to form sensory mechanotransduction channels, the evidence for this role remains indirect. By recording from C. elegans touch receptor neurons in vivo, we found that external...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1362
更新日期:2005-01-01 00:00:00
abstract::Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-017-0004-1
更新日期:2017-12-01 00:00:00
abstract::Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3131
更新日期:2012-06-03 00:00:00
abstract::During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn971
更新日期:2002-12-01 00:00:00
abstract::Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4022
更新日期:2015-06-01 00:00:00