Silencing of EphA3 through a cis interaction with ephrinA5.

abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...

journal_title：Nature neuroscience

authors： Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC

更新日期：2008-03-01 00:00:00

abstract：:Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear. Activity-dependent transcription of genes for neurotrophins such as brain-derived neurotrophic factor (BDNF) has been shown to promote epileptogenesis; however, little is known a...

journal_title：Nature neuroscience

authors： Tan GH,Liu YY,Hu XL,Yin DM,Mei L,Xiong ZQ

更新日期：2011-12-11 00:00:00

abstract：:Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...

journal_title：Nature neuroscience

authors： St-Pierre F,Marshall JD,Yang Y,Gong Y,Schnitzer MJ,Lin MZ

更新日期：2014-06-01 00:00:00

abstract：:Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...

journal_title：Nature neuroscience

authors： Fenselau H,Campbell JN,Verstegen AM,Madara JC,Xu J,Shah BP,Resch JM,Yang Z,Mandelblat-Cerf Y,Livneh Y,Lowell BB

更新日期：2017-01-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...

journal_title：Nature neuroscience

authors： Bello EP,Mateo Y,Gelman DM,Noaín D,Shin JH,Low MJ,Alvarez VA,Lovinger DM,Rubinstein M

更新日期：2011-07-10 00:00:00

abstract：:As we move through the environment, the pattern of visual motion on the retina provides rich information about our movement through the scene. Human subjects can use this information, often termed "optic flow", to accurately estimate their direction of self movement (heading) from relatively sparse displays. Physiolog...

journal_title：Nature neuroscience

authors： Britten KH,van Wezel RJ

更新日期：1998-05-01 00:00:00

abstract：:The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...

journal_title：Nature neuroscience

authors： Davis KD,Pope GE,Crawley AP,Mikulis DJ

更新日期：2002-11-01 00:00:00

abstract：:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...

journal_title：Nature neuroscience

authors： Murray AJ,Sauer JF,Riedel G,McClure C,Ansel L,Cheyne L,Bartos M,Wisden W,Wulff P

更新日期：2011-03-01 00:00:00

abstract：:The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...

journal_title：Nature neuroscience

authors： Hawrylycz M,Miller JA,Menon V,Feng D,Dolbeare T,Guillozet-Bongaarts AL,Jegga AG,Aronow BJ,Lee CK,Bernard A,Glasser MF,Dierker DL,Menche J,Szafer A,Collman F,Grange P,Berman KA,Mihalas S,Yao Z,Stewart L,Barabási AL

更新日期：2015-12-01 00:00:00

abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...

journal_title：Nature neuroscience

authors： Mainland JD,Keller A,Li YR,Zhou T,Trimmer C,Snyder LL,Moberly AH,Adipietro KA,Liu WL,Zhuang H,Zhan S,Lee SS,Lin A,Matsunami H

更新日期：2014-01-01 00:00:00

abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...

journal_title：Nature neuroscience

authors： Singh T,Kurki MI,Curtis D,Purcell SM,Crooks L,McRae J,Suvisaari J,Chheda H,Blackwood D,Breen G,Pietiläinen O,Gerety SS,Ayub M,Blyth M,Cole T,Collier D,Coomber EL,Craddock N,Daly MJ,Danesh J,DiForti M,Foster A,

更新日期：2016-04-01 00:00:00

abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...

journal_title：Nature neuroscience

authors： Carandini M

更新日期：2012-03-27 00:00:00

abstract：:Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CP...

journal_title：Nature neuroscience

authors： Villarreal DM,Do V,Haddad E,Derrick BE

更新日期：2002-01-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00

abstract：:In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

journal_title：Nature neuroscience

authors： Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

更新日期：2006-03-01 00:00:00

abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...

journal_title：Nature neuroscience

authors： Yeshurun Y,Carrasco M

更新日期：2000-06-01 00:00:00

abstract：:In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cin...

journal_title：Nature neuroscience

authors： Narayanan NS,Cavanagh JF,Frank MJ,Laubach M

更新日期：2013-12-01 00:00:00

abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...

journal_title：Nature neuroscience

authors： Kay LM,Laurent G

更新日期：1999-11-01 00:00:00

abstract：:Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...

journal_title：Nature neuroscience

authors： Lynch G

更新日期：2002-11-01 00:00:00

abstract：:The amygdala is essential for fear learning and expression. The central amygdala (CeA), once viewed as a passive relay between the amygdala complex and downstream fear effectors, has emerged as an active participant in fear conditioning. However, the mechanism by which CeA contributes to the learning and expression of...

journal_title：Nature neuroscience

authors： Li H,Penzo MA,Taniguchi H,Kopec CD,Huang ZJ,Li B

更新日期：2013-03-01 00:00:00

abstract：:Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived from microglial progenitor cells expressing nestin in the brain. However, the origin of these repopulated microglia has been ...

journal_title：Nature neuroscience

authors： Huang Y,Xu Z,Xiong S,Sun F,Qin G,Hu G,Wang J,Zhao L,Liang YX,Wu T,Lu Z,Humayun MS,So KF,Pan Y,Li N,Yuan TF,Rao Y,Peng B

更新日期：2018-04-01 00:00:00

abstract：:We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...

journal_title：Nature neuroscience

authors： Miceli G,Fouch E,Capasso R,Shelton JR,Tomaiuolo F,Caramazza A

更新日期：2001-06-01 00:00:00

abstract：:Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...

journal_title：Nature neuroscience

authors： García-Alías G,Barkhuysen S,Buckle M,Fawcett JW

更新日期：2009-09-01 00:00:00

abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...

journal_title：Nature neuroscience

authors： Huang H,Kong D,Byun KH,Ye C,Koda S,Lee DH,Oh BC,Lee SW,Lee B,Zabolotny JM,Kim MS,Bjørbæk C,Lowell BB,Kim YB

更新日期：2012-10-01 00:00:00

abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...

journal_title：Nature neuroscience

authors： Rolfs M,Jonikaitis D,Deubel H,Cavanagh P

更新日期：2011-02-01 00:00:00

abstract：:Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury. ...

journal_title：Nature neuroscience

authors： Kettenmann H

更新日期：2006-12-01 00:00:00

abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...

journal_title：Nature neuroscience

authors： Chen G,Kim YH,Li H,Luo H,Liu DL,Zhang ZJ,Lay M,Chang W,Zhang YQ,Ji RR

更新日期：2019-03-01 00:00:00

abstract：:An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...

journal_title：Nature neuroscience

authors： Theyel BB,Llano DA,Sherman SM

更新日期：2010-01-01 00:00:00

abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...

journal_title：Nature neuroscience

authors： Oram MW,Richmond BJ

更新日期：1999-10-01 00:00:00