Abstract:
:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Bibel M,Richter J,Schrenk K,Tucker KL,Staiger V,Korte M,Goetz M,Barde YAdoi
10.1038/nn1301subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1003-9issue
9eissn
1097-6256issn
1546-1726pii
nn1301journal_volume
7pub_type
杂志文章abstract::The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...
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doi:10.1038/nn.4285
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abstract::Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title:Nature neuroscience
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doi:10.1038/nn.2513
更新日期:2010-05-01 00:00:00
abstract::We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...
journal_title:Nature neuroscience
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journal_title:Nature neuroscience
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doi:10.1038/nn.4323
更新日期:2016-08-01 00:00:00
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journal_title:Nature neuroscience
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doi:10.1038/nn.2711
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abstract::Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3043
更新日期:2012-03-27 00:00:00
abstract::An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...
journal_title:Nature neuroscience
pub_type: 杂志文章
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journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn805
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abstract::In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
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更新日期:2015-04-01 00:00:00
abstract::We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...
journal_title:Nature neuroscience
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract::GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to s...
journal_title:Nature neuroscience
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更新日期:2021-01-01 00:00:00
abstract::Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/5715
更新日期:1999-02-01 00:00:00
abstract::Protein-coding de novo mutations (DNMs) are significant risk factors in many neurodevelopmental disorders, whereas schizophrenia (SCZ) risk associated with DNMs has thus far been shown to be modest. We analyzed DNMs from 1,695 SCZ-affected trios and 1,077 published SCZ-affected trios to better understand the contribut...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0564-3
更新日期:2020-02-01 00:00:00
abstract::Radial glial progenitor cells exhibit bidirectional cell cycle-dependent nuclear oscillations. The purpose and underlying mechanism of this unusual 'interkinetic nuclear migration' are poorly understood. We investigated the basis for this behavior by live imaging of nuclei, centrosomes and microtubules in embryonic ra...
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doi:10.1038/nn.2665
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abstract::The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn788
更新日期:2002-02-01 00:00:00
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journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn971
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doi:10.1038/nn.2750
更新日期:2011-03-01 00:00:00
abstract::Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 ca...
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journal_title:Nature neuroscience
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pub_type: 评论,杂志文章,评审
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更新日期:2008-03-01 00:00:00
abstract::Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1980
更新日期:2007-10-01 00:00:00
abstract::The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3348
更新日期:2013-04-01 00:00:00
abstract::In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3761
更新日期:2014-08-01 00:00:00
abstract::In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4378
更新日期:2016-09-27 00:00:00
abstract::Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency burst firing. We found t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3185
更新日期:2012-09-01 00:00:00
abstract::Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title:Nature neuroscience
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更新日期:2006-06-01 00:00:00