Abstract：
:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the neocortical microcirculation. Such endothelial dysfunction was not found in transgenic mice expressing both APP and superoxide dismutase-1 (SOD1) or in APP transgenics in which SOD was topically applied to the cerebral cortex. These cerebrovascular effects of peptides derived from APP processing may contribute to the alterations in cerebral blood flow and to neuronal dysfunction in Alzheimer's dementia.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Iadecola C,Zhang F,Niwa K,Eckman C,Turner SK,Fischer E,Younkin S,Borchelt DR,Hsiao KK,Carlson GAdoi
10.1038/5715subject
Has Abstractpub_date
1999-02-01 00:00:00pages
157-61issue
2eissn
1097-6256issn
1546-1726journal_volume
2pub_type
杂志文章abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
abstract：:Forces developed by cochlear outer hair cells (OHCs) are responsible for the sharp tuning that underlies sensitivity and frequency selectivity in the ear. OHCs exhibit a voltage-dependent motility involving a 'motor' protein embedded in the basolateral membrane. The motor has so far resisted molecular identification. ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/11174
更新日期：1999-08-01 00:00:00
abstract：:Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3785
更新日期：2014-09-01 00:00:00
abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/76630
更新日期：2000-07-01 00:00:00
abstract：:Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1338
更新日期：2004-11-01 00:00:00
abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4350
更新日期：2016-09-01 00:00:00
abstract：:Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/4553
更新日期：1999-01-01 00:00:00
abstract：:Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-017-0020-1
更新日期：2017-12-01 00:00:00
abstract：:An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1600
更新日期：2005-12-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-0595-9
更新日期：2020-02-01 00:00:00
abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0323-x
更新日期：2019-03-01 00:00:00
abstract：:The usefulness of genetically encoded probes for optical monitoring of neuronal activity and brain circuits would be greatly advanced by the generation of multiple indicators with non-overlapping color spectra. Most existing indicators are derived from or spectrally convergent on GFP. We generated a bright, red, pH-se...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3126
更新日期：2012-05-27 00:00:00
abstract：:Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2264
更新日期：2009-03-01 00:00:00
abstract：:The majority of neurons in primary visual cortex are tuned for stimulus orientation, but the factors that account for the range of orientation selectivities exhibited by cortical neurons remain unclear. To address this issue, we used in vivo two-photon calcium imaging to characterize the orientation tuning and spatial...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4323
更新日期：2016-08-01 00:00:00
abstract：:Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00733-0
更新日期：2021-01-01 00:00:00
abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1150
更新日期：2003-12-01 00:00:00
abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn811
更新日期：2002-03-01 00:00:00
abstract：:Some neurons in auditory cortex respond to recent stimulus history by adapting their response functions to track stimulus statistics directly, as might be expected. In contrast, some neurons respond to loud sounds by adjusting their response functions away from high intensities and consequently remain sensitive to sof...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2201
更新日期：2008-11-01 00:00:00
abstract：:Mammalian hearing owes its remarkable sensitivity and frequency selectivity to a local mechanical feedback process within the cochlea. Cochlear outer hair cells (OHCs) function as the key elements in the feedback loop in which the fast somatic motility of OHCs is thought to be the source of cochlear amplification. An ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1509
更新日期：2005-08-01 00:00:00
abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
abstract：:Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing-dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arri...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2479
更新日期：2010-03-01 00:00:00
abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3811
更新日期：2014-10-01 00:00:00
abstract：:A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/75718
更新日期：2000-06-01 00:00:00
abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2931
更新日期：2011-10-02 00:00:00
abstract：:We elucidated the intrinsic circuitry of the medial prefrontal cortex and its role in regulating fear extinction, using neuronal tracing and optogenetic stimulation in vitro and in vivo. We show that pyramidal neurons in layer 5/6 of the prelimbic medial prefrontal cortex project to pyramidal cells in layer 5/6 of the...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0137-x
更新日期：2018-05-01 00:00:00
abstract：:Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1845
更新日期：2007-03-01 00:00:00
abstract：:Transposable elements, known colloquially as 'jumping genes', constitute approximately 45% of the human genome. Cells utilize epigenetic defenses to limit transposable element jumping, including formation of silencing heterochromatin and generation of piwi-interacting RNAs (piRNAs), small RNAs that facilitate clearanc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0194-1
更新日期：2018-08-01 00:00:00
abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2350
更新日期：2009-07-01 00:00:00
