Abstract：
:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establishment of tonotopy are poorly understood. In auditory brainstem pathways, topographic precision is present at very early stages in development, which may suggest that synaptic reorganization contributes little to the construction of precise tonotopic maps. Accumulating evidence from several brainstem nuclei, however, is now changing this view by demonstrating that developing auditory brainstem circuits undergo a marked degree of refinement on both a subcellular and circuit level.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kandler K,Clause A,Noh Jdoi
10.1038/nn.2332subject
Has Abstractpub_date
2009-06-01 00:00:00pages
711-7issue
6eissn
1097-6256issn
1546-1726pii
nn.2332journal_volume
12pub_type
杂志文章,评审abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...
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