Abstract：
:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of sugar. During sugar intake, suppressing hedonic value inhibited dopamine release in ventral, but not dorsal, striatum, whereas suppressing nutritional value inhibited dopamine release in dorsal, but not ventral, striatum. Consistently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar's ability to drive the ingestion of unpalatable solutions. Conversely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum substituted for sugar in its ability to drive the ingestion of unpalatable solutions. Our data indicate that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize energy-seeking over taste quality.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IEdoi
10.1038/nn.4224subject
Has Abstractpub_date
2016-03-01 00:00:00pages
465-70issue
3eissn
1097-6256issn
1546-1726pii
nn.4224journal_volume
19pub_type
杂志文章abstract：:Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0155-8
更新日期：2018-06-01 00:00:00
abstract：:Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1160
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abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3001
更新日期：2011-12-25 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2012-07-26 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1431
更新日期：2005-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn962
更新日期：2002-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3616
更新日期：2014-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4433
更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.3180
更新日期：2012-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4025
更新日期：2015-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1559
更新日期：2005-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2540
更新日期：2010-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2135
更新日期：2008-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1949
更新日期：2007-09-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 已发布勘误
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更新日期：2003-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2006-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2006-11-01 00:00:00
