AlphaCaMKII autophosphorylation contributes to rapid learning but is not necessary for memory.

abstract：:Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...

journal_title：Nature neuroscience

authors： Wimber M,Alink A,Charest I,Kriegeskorte N,Anderson MC

更新日期：2015-04-01 00:00:00

abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...

journal_title：Nature neuroscience

authors： Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJ

更新日期：2004-06-01 00:00:00

abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...

journal_title：Nature neuroscience

authors： Beattie EC,Carroll RC,Yu X,Morishita W,Yasuda H,von Zastrow M,Malenka RC

更新日期：2000-12-01 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:Imaging, from magnetic resonance imaging (MRI) to localization of specific macromolecules by microscopies, has been one of the driving forces behind neuroinformatics efforts of the past decade. Many web-accessible resources have been created, ranging from simple data collections to highly structured databases. Althoug...

journal_title：Nature neuroscience

authors： Martone ME,Gupta A,Ellisman MH

更新日期：2004-05-01 00:00:00

abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...

journal_title：Nature neuroscience

authors： Fischer AJ,Reh TA

更新日期：2001-03-01 00:00:00

abstract：:Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...

journal_title：Nature neuroscience

authors： Xu S,Jiang W,Poo MM,Dan Y

更新日期：2012-01-22 00:00:00

abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...

journal_title：Nature neuroscience

authors： Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

更新日期：2010-06-01 00:00:00

abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...

journal_title：Nature neuroscience

authors： Iadecola C,Zhang F,Niwa K,Eckman C,Turner SK,Fischer E,Younkin S,Borchelt DR,Hsiao KK,Carlson GA

更新日期：1999-02-01 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

journal_title：Nature neuroscience

authors： Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

更新日期：2007-06-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...

journal_title：Nature neuroscience

authors： Carandini M

更新日期：2012-03-27 00:00:00

abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...

journal_title：Nature neuroscience

authors： Labouèbe G,Lomazzi M,Cruz HG,Creton C,Luján R,Li M,Yanagawa Y,Obata K,Watanabe M,Wickman K,Boyer SB,Slesinger PA,Lüscher C

更新日期：2007-12-01 00:00:00

abstract：:The excitability of individual dendritic branches is a plastic property of neurons. We found that experience in an enriched environment increased propagation of dendritic Na(+) spikes in a subset of individual dendritic branches in rat hippocampal CA1 pyramidal neurons and that this effect was mainly mediated by local...

journal_title：Nature neuroscience

authors： Makara JK,Losonczy A,Wen Q,Magee JC

更新日期：2009-12-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...

journal_title：Nature neuroscience

authors： Takenaka MC,Gabriely G,Rothhammer V,Mascanfroni ID,Wheeler MA,Chao CC,Gutiérrez-Vázquez C,Kenison J,Tjon EC,Barroso A,Vandeventer T,de Lima KA,Rothweiler S,Mayo L,Ghannam S,Zandee S,Healy L,Sherr D,Farez MF,Prat A,

更新日期：2019-05-01 00:00:00

abstract：:The structure and function of the human brain are highly stereotyped, implying a conserved molecular program responsible for its development, cellular structure and function. We applied a correlation-based metric called differential stability to assess reproducibility of gene expression patterning across 132 structure...

journal_title：Nature neuroscience

authors： Hawrylycz M,Miller JA,Menon V,Feng D,Dolbeare T,Guillozet-Bongaarts AL,Jegga AG,Aronow BJ,Lee CK,Bernard A,Glasser MF,Dierker DL,Menche J,Szafer A,Collman F,Grange P,Berman KA,Mihalas S,Yao Z,Stewart L,Barabási AL

更新日期：2015-12-01 00:00:00

abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...

journal_title：Nature neuroscience

authors： Sandoe J,Eggan K

更新日期：2013-07-01 00:00:00

abstract：:Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical s...

journal_title：Nature neuroscience

authors： Kilgard MP,Merzenich MM

更新日期：1998-12-01 00:00:00

abstract：:Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...

journal_title：Nature neuroscience

authors： Land BB,Narayanan NS,Liu RJ,Gianessi CA,Brayton CE,Grimaldi DM,Sarhan M,Guarnieri DJ,Deisseroth K,Aghajanian GK,DiLeone RJ

更新日期：2014-02-01 00:00:00

abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...

journal_title：Nature neuroscience

authors： Oesch NW,Diamond JS

更新日期：2011-10-23 00:00:00

abstract：:En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a ...

journal_title：Nature neuroscience

authors： Zhang J,Lefebvre JL,Zhao S,Granato M

更新日期：2004-12-01 00:00:00

abstract：:The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neur...

journal_title：Nature neuroscience

authors： Thoby-Brisson M,Karlén M,Wu N,Charnay P,Champagnat J,Fortin G

更新日期：2009-08-01 00:00:00

abstract：:Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin. ...

journal_title：Nature neuroscience

authors： Craig AM,Lichtman JW

更新日期：2001-03-01 00:00:00

abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...

journal_title：Nature neuroscience

authors： Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IE

更新日期：2016-03-01 00:00:00

abstract：:The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

journal_title：Nature neuroscience

authors： Potter CJ,Luo L

更新日期：2008-09-01 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...

journal_title：Nature neuroscience

authors： Samuel MA,Voinescu PE,Lilley BN,de Cabo R,Foretz M,Viollet B,Pawlyk B,Sandberg MA,Vavvas DG,Sanes JR

更新日期：2014-09-01 00:00:00

abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...

journal_title：Nature neuroscience

authors： Huang H,Kong D,Byun KH,Ye C,Koda S,Lee DH,Oh BC,Lee SW,Lee B,Zabolotny JM,Kim MS,Bjørbæk C,Lowell BB,Kim YB

更新日期：2012-10-01 00:00:00