Abstract:
:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein-mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells. Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZdoi
10.1038/nn.2540subject
Has Abstractpub_date
2010-06-01 00:00:00pages
715-22issue
6eissn
1097-6256issn
1546-1726pii
nn.2540journal_volume
13pub_type
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