Abstract：
:Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex and inhibit prefrontal cortical pyramidal neurons in a robust and reliable manner. These mesocortical neurons were derived from a subset of dopaminergic progenitors, which were dependent on prolonged Sonic Hedgehog signaling for their induction. Loss of these progenitors resulted in the loss of the mesocortical inhibitory circuit and an increase in perseverative behavior, whereas mesolimbic and mesostriatal dopaminergic projections, as well as impulsivity and attentional function, were largely spared. Thus, we identified a previously uncharacterized mesocortical circuit contributing to perseverative behaviors and found that the diversity of dopaminergic neurons begins to be established during their progenitor phase.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kabanova A,Pabst M,Lorkowski M,Braganza O,Boehlen A,Nikbakht N,Pothmann L,Vaswani AR,Musgrove R,Di Monte DA,Sauvage M,Beck H,Blaess Sdoi
10.1038/nn.4020subject
Has Abstractpub_date
2015-06-01 00:00:00pages
872-82issue
6eissn
1097-6256issn
1546-1726pii
nn.4020journal_volume
18pub_type
杂志文章abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
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更新日期：2005-04-01 00:00:00
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