Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys.

Abstract:

:Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused by humans, as well as for nicotine, the psychoactive ingredient in tobacco, these studies would seem to indicate that marijuana has less potential for abuse. Here we show persistent intravenous self-administration behavior by monkeys for doses of THC lower than doses used in previous studies, but comparable to doses in marijuana smoke inhaled by humans.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Tanda G,Munzar P,Goldberg SR

doi

10.1038/80577

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

1073-4

issue

11

eissn

1097-6256

issn

1546-1726

journal_volume

3

pub_type

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