Abstract:
:Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused by humans, as well as for nicotine, the psychoactive ingredient in tobacco, these studies would seem to indicate that marijuana has less potential for abuse. Here we show persistent intravenous self-administration behavior by monkeys for doses of THC lower than doses used in previous studies, but comparable to doses in marijuana smoke inhaled by humans.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Tanda G,Munzar P,Goldberg SRdoi
10.1038/80577subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1073-4issue
11eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract::Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...
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doi:10.1038/nn.2750
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journal_title:Nature neuroscience
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doi:10.1038/nn1568
更新日期:2005-11-01 00:00:00
abstract::In the version of this article initially published, the annotation accompanying ref. 47 ended with "though the modulation of microglia." The first word of this phrase should have been "through." The error has been corrected in the HTML and PDF versions of the article. ...
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pub_type: 已发布勘误
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doi:10.1038/nn.3373
更新日期:2013-05-01 00:00:00
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doi:10.1038/nn1586
更新日期:2005-12-01 00:00:00
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doi:10.1038/nn.3761
更新日期:2014-08-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Nature neuroscience
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doi:10.1038/nn.3100
更新日期:2012-06-01 00:00:00
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更新日期:2013-12-01 00:00:00
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