Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Keysers C,Gazzola V,Wagenmakers EJdoi
10.1038/s41593-020-00710-7subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1453issue
11eissn
1097-6256issn
1546-1726pii
10.1038/s41593-020-00710-7journal_volume
23pub_type
已发布勘误abstract::Precise apposition of pre- to postsynaptic specializations is required for optimal function of chemical synapses, but little is known about how it is achieved. At the skeletal neuromuscular junction, active zones (transmitter release sites) in the nerve terminal lie directly opposite junctional folds in the postsynapt...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/88414
更新日期:2001-06-01 00:00:00
abstract::Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn935
更新日期:2002-11-01 00:00:00
abstract::Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4553
更新日期:2017-06-01 00:00:00
abstract::Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3592
更新日期:2014-01-01 00:00:00
abstract::An afterimage looks larger when one fixates on a distant than on a closer surface. We show that the retinotopic activity in the primary visual cortex (V1) associated with viewing an afterimage is modulated by perceived size, even when the size of the retinal image remains constant. This suggests that V1 has an importa...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3069
更新日期:2012-03-11 00:00:00
abstract::Midbrain ventral tegmental neurons project to the prefrontal cortex and modulate cognitive functions. Using viral tracing, optogenetics and electrophysiology, we found that mesocortical neurons in the mouse ventrotegmental area provide fast glutamatergic excitation of GABAergic interneurons in the prefrontal cortex an...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4020
更新日期:2015-06-01 00:00:00
abstract::Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3139
更新日期:2012-06-17 00:00:00
abstract::Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3494
更新日期:2013-09-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-019-0546-5
更新日期:2019-12-01 00:00:00
abstract::Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1754
更新日期:2006-09-01 00:00:00
abstract::In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0114-4
更新日期:2018-07-01 00:00:00
abstract::In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0183-4
更新日期:2018-09-01 00:00:00
abstract::The US government is re-examining how it funds science, but it remains to be seen whether the administration can overcome tradition and bureaucratic inertia and achieve a substantial renovation of the grants peer-review system. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/nn0208-119
更新日期:2008-02-01 00:00:00
abstract::Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/85191
更新日期:2001-03-01 00:00:00
abstract::Blood flow into the brain is dynamically regulated to satisfy the changing metabolic requirements of neurons, but how this is accomplished has remained unclear. Here we demonstrate a central role for capillary endothelial cells in sensing neural activity and communicating it to upstream arterioles in the form of an el...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4533
更新日期:2017-05-01 00:00:00
abstract::Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2816
更新日期:2011-06-01 00:00:00
abstract::Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1417
更新日期:2005-04-01 00:00:00
abstract::The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4656
更新日期:2017-10-26 00:00:00
abstract::A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3001
更新日期:2011-12-25 00:00:00
abstract::Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn967
更新日期:2002-12-01 00:00:00
abstract::Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2901
更新日期:2011-09-11 00:00:00
abstract::In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0075-7
更新日期:2018-03-01 00:00:00
abstract::Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2558
更新日期:2010-06-01 00:00:00
abstract::Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4517
更新日期:2017-04-01 00:00:00
abstract::Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1867
更新日期:2007-04-01 00:00:00
abstract::Attention powerfully influences auditory perception, but little is understood about the mechanisms whereby attention sharpens responses to unattended sounds. We used high-resolution surface mapping techniques (using functional magnetic resonance imaging, fMRI) to examine activity in human auditory cortex during an int...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1256
更新日期:2004-06-01 00:00:00
abstract::Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3764
更新日期:2014-08-01 00:00:00
abstract::Major, rapid performance improvements in perceptual training are often dismissed as 'task' or 'procedural' learning because they are fast and generalize within a task. We assessed the contributions of perceptual and procedural learning to improvement in an auditory tone frequency learning task in humans and found that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1315
更新日期:2004-10-01 00:00:00
abstract::Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3835
更新日期:2014-11-01 00:00:00
abstract::Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3234
更新日期:2012-11-01 00:00:00