Retinotopic activity in V1 reflects the perceived and not the retinal size of an afterimage.

abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...

journal_title：Nature neuroscience

authors： Nery S,Fishell G,Corbin JG

更新日期：2002-12-01 00:00:00

abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...

journal_title：Nature neuroscience

authors： Tsai J,Grutzendler J,Duff K,Gan WB

更新日期：2004-11-01 00:00:00

abstract：:Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural a...

journal_title：Nature neuroscience

authors： Hua JY,Smith SJ

更新日期：2004-04-01 00:00:00

abstract：:Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...

journal_title：Nature neuroscience

authors： Zhou X,Merzenich MM

更新日期：2009-01-01 00:00:00

abstract：:The growth of neurites (axon and dendrite) should be appropriately regulated by their interactions in the development of nervous systems where a myriad of neurons and their neurites are tightly packed. We show here that mammalian seven-pass transmembrane cadherins Celsr2 and Celsr3 are activated by their homophilic in...

journal_title：Nature neuroscience

authors： Shima Y,Kawaguchi SY,Kosaka K,Nakayama M,Hoshino M,Nabeshima Y,Hirano T,Uemura T

更新日期：2007-08-01 00:00:00

abstract：:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...

journal_title：Nature neuroscience

authors： Mameli M,Bellone C,Brown MT,Lüscher C

更新日期：2011-04-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants, but the mechanisms by which they influence behavior are only partially resolved. Adult hippocampal neurogenesis is necessary for some of the responses to SSRIs, but it is not known whether mature dentate gyrus granule cells (DG GCs) also ...

journal_title：Nature neuroscience

authors： Samuels BA,Anacker C,Hu A,Levinstein MR,Pickenhagen A,Tsetsenis T,Madroñal N,Donaldson ZR,Drew LJ,Dranovsky A,Gross CT,Tanaka KF,Hen R

更新日期：2015-11-01 00:00:00

abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...

journal_title：Nature neuroscience

authors： Wolpert DM,Ghahramani Z

更新日期：2000-11-01 00:00:00

abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...

journal_title：Nature neuroscience

authors： Vuilleumier P,Armony JL,Driver J,Dolan RJ

更新日期：2003-06-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...

journal_title：Nature neuroscience

authors： Viard P,Butcher AJ,Halet G,Davies A,Nürnberg B,Heblich F,Dolphin AC

更新日期：2004-09-01 00:00:00

abstract：:Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the abi...

journal_title：Nature neuroscience

authors： Wang SH,de Oliveira Alvares L,Nader K

更新日期：2009-07-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in ...

journal_title：Nature neuroscience

authors： O'Connor DH,Hires SA,Guo ZV,Li N,Yu J,Sun QQ,Huber D,Svoboda K

更新日期：2013-07-01 00:00:00

abstract：:Replay of hippocampal place cell sequences has been proposed as a fundamental mechanism of learning and memory. However, the standard interpretation of replay has been challenged by reports that similar activity is observed before experience ('preplay'). By the preplay account, pre-existing temporal sequences are mapp...

journal_title：Nature neuroscience

authors： Silva D,Feng T,Foster DJ

更新日期：2015-12-01 00:00:00

abstract：:The diseased brain hosts a heterogeneous population of myeloid cells, including parenchymal microglia, perivascular cells, meningeal macrophages and blood-borne monocytes. To date, the different types of brain myeloid cells have been discriminated solely on the basis of their localization, morphology and surface epito...

journal_title：Nature neuroscience

authors： Prinz M,Priller J,Sisodia SS,Ransohoff RM

更新日期：2011-09-27 00:00:00

abstract：:Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical s...

journal_title：Nature neuroscience

authors： Kilgard MP,Merzenich MM

更新日期：1998-12-01 00:00:00

abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...

journal_title：Nature neuroscience

authors： Soto C,Pritzkow S

更新日期：2018-10-01 00:00:00

abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...

journal_title：Nature neuroscience

authors： Carandini M

更新日期：2012-03-27 00:00:00

abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...

journal_title：Nature neuroscience

authors： Couey JJ,Witoelar A,Zhang SJ,Zheng K,Ye J,Dunn B,Czajkowski R,Moser MB,Moser EI,Roudi Y,Witter MP

更新日期：2013-03-01 00:00:00

abstract：:Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...

journal_title：Nature neuroscience

authors： Haynes SE,Hollopeter G,Yang G,Kurpius D,Dailey ME,Gan WB,Julius D

更新日期：2006-12-01 00:00:00

abstract：:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene E...

journal_title：Nature neuroscience

authors： Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli E

更新日期：2000-07-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...

journal_title：Nature neuroscience

authors： Shou J,Rim PC,Calof AL

更新日期：1999-04-01 00:00:00

abstract：:A decade after speech was first decoded from human brain signals, accuracy and speed remain far below that of natural speech. Here we show how to decode the electrocorticogram with high accuracy and at natural-speech rates. Taking a cue from recent advances in machine translation, we train a recurrent neural network t...

journal_title：Nature neuroscience

authors： Makin JG,Moses DA,Chang EF

更新日期：2020-04-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked end...

journal_title：Nature neuroscience

authors： Brown SP,Brenowitz SD,Regehr WG

更新日期：2003-10-01 00:00:00

abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...

journal_title：Nature neuroscience

authors： Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC

更新日期：2008-03-01 00:00:00

abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...

journal_title：Nature neuroscience

authors： Nestler EJ

更新日期：2002-11-01 00:00:00

abstract：:What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...

journal_title：Nature neuroscience

authors： Todorov E

更新日期：2000-04-01 00:00:00

abstract：:Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alco...

journal_title：Nature neuroscience

authors： Lovinger DM,Crabbe JC

更新日期：2005-11-01 00:00:00

abstract：:Neural activity exhibits complex dynamics related to various brain functions, internal states and behaviors. Understanding how neural dynamics explain specific measured behaviors requires dissociating behaviorally relevant and irrelevant dynamics, which is not achieved with current neural dynamic models as they are le...

journal_title：Nature neuroscience

authors： Sani OG,Abbaspourazad H,Wong YT,Pesaran B,Shanechi MM

更新日期：2021-01-01 00:00:00