Abstract:
:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational approach provide a theoretical framework for movement neuroscience.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Wolpert DM,Ghahramani Zdoi
10.1038/81497subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1212-7eissn
1097-6256issn
1546-1726journal_volume
3 Supplpub_type
杂志文章,评审abstract::Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0405-4
更新日期:2019-06-01 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1718
更新日期:2006-07-01 00:00:00
abstract::Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nuc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1949
更新日期:2007-09-01 00:00:00
abstract::The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4475
更新日期:2017-02-01 00:00:00
abstract::An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/89522
更新日期:2001-07-01 00:00:00
abstract::Hippocampal long-term potentiation (LTP) induced by theta-burst pairing of Schaffer collateral inputs and postsynaptic firing is associated with localized increases in synaptic strength and dendritic excitability. Using the same protocol, we now demonstrate a decrease in cellular excitability that was blocked by the h...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1568
更新日期:2005-11-01 00:00:00
abstract::Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2146
更新日期:2008-07-01 00:00:00
abstract::Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/71156
更新日期:2000-01-01 00:00:00
abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/5715
更新日期:1999-02-01 00:00:00
abstract::To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant excess of rare protein-truncating variants among ALS cases, and these variants were concentrated in constrained genes. Through gene level analyses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0530-0
更新日期:2019-12-01 00:00:00
abstract::Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2513
更新日期:2010-05-01 00:00:00
abstract::The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1936
更新日期:2007-08-01 00:00:00
abstract::Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar geno...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0155-8
更新日期:2018-06-01 00:00:00
abstract::Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imag...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2773
更新日期:2011-05-01 00:00:00
abstract::Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3598
更新日期:2014-01-01 00:00:00
abstract::Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4313
更新日期:2016-07-01 00:00:00
abstract::Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0094-4
更新日期:2018-04-01 00:00:00
abstract::It is often assumed that all neurons of the same cell type have identical intrinsic properties, both within an animal and between animals. We exploited the large size and small number of unambiguously identifiable neurons in the crab stomatogastric ganglion to test this assumption at the level of channel mRNA expressi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1639
更新日期:2006-03-01 00:00:00
abstract::In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3761
更新日期:2014-08-01 00:00:00
abstract::Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3407
更新日期:2013-07-01 00:00:00
abstract::The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4444
更新日期:2017-01-01 00:00:00
abstract::Major, rapid performance improvements in perceptual training are often dismissed as 'task' or 'procedural' learning because they are fast and generalize within a task. We assessed the contributions of perceptual and procedural learning to improvement in an auditory tone frequency learning task in humans and found that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1315
更新日期:2004-10-01 00:00:00
abstract::The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4300
更新日期:2016-06-01 00:00:00
abstract::Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3180
更新日期:2012-09-01 00:00:00
abstract::Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3709
更新日期:2014-06-01 00:00:00
abstract::Cue-triggered recall of learned temporal sequences is an important cognitive function that has been attributed to higher brain areas. Here recordings in both anesthetized and awake rats demonstrate that after repeated stimulation with a moving spot that evoked sequential firing of an ensemble of primary visual cortex ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3036
更新日期:2012-01-22 00:00:00
abstract::The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2763
更新日期:2011-04-01 00:00:00
abstract::En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1350
更新日期:2004-12-01 00:00:00
abstract::The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1168
更新日期:2004-01-01 00:00:00
abstract::Processing of rapidly successive acoustic stimuli can be markedly improved by sensory training. To investigate the cortical mechanisms underlying such temporal plasticity, we trained rats in a 'sound maze' in which navigation using only auditory cues led to a target location paired with food reward. In this task, the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1293
更新日期:2004-09-01 00:00:00