Brief presynaptic bursts evoke synapse-specific retrograde inhibition mediated by endogenous cannabinoids.

Abstract:

:Many types of neurons can release endocannabinoids that act as retrograde signals to inhibit neurotransmitter release from presynaptic terminals. Little is known, however, about the properties or role of such inhibition under physiological conditions. Here we report that brief bursts of presynaptic activity evoked endocannabinoid release, which strongly inhibited parallel fiber-to-Purkinje cell synapses in rat cerebellar slices. This retrograde inhibition was triggered by activation of either postsynaptic metabotropic or ionotropic glutamate receptors and was restricted to synapses activated with high-frequency bursts. Thus, endocannabinoids allow neurons to inhibit specific synaptic inputs in response to a burst, thereby dynamically fine-tuning the properties of synaptic integration.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Brown SP,Brenowitz SD,Regehr WG

doi

10.1038/nn1126

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1048-57

issue

10

eissn

1097-6256

issn

1546-1726

pii

nn1126

journal_volume

6

pub_type

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