Abstract：
:The specification of area identities in the cerebral cortex is a complex process, primed by intrinsic cortical cues and refined after the arrival of afferent fibers from the thalamus. Little is known about the genetic control of the early steps of this process, but the distinctive expression pattern of the homeogene Emx2 in the developing cortex has prompted suggestions that it is critical in this context. We tested this hypothesis using Emx2 -/- mice. We found that the normal spectrum of cortical areal identities was encoded in these mutants, but areas with caudal-medial identities were reduced and those with anterior-lateral identities were relatively expanded in the cortex.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Mallamaci A,Muzio L,Chan CH,Parnavelas J,Boncinelli Edoi
10.1038/76630subject
Has Abstractpub_date
2000-07-01 00:00:00pages
679-86issue
7eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:Accumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main pathology in affected neurons of people with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Morphological diversity and neuroanatomical distribution of pTDP-43 accumulations allowed classification of FTLD cases in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0294-y
更新日期：2019-01-01 00:00:00
abstract：:Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0593-y
更新日期：2020-04-01 00:00:00
abstract：:To investigate synaptic events underlying sensory perception, we made whole-cell membrane potential recordings of barrel cortex neurons in awake mice while recording whisker-related behavior. During quiet periods, we recorded slow, large-amplitude membrane potential changes, which switched during whisking to small, fa...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1690
更新日期：2006-05-01 00:00:00
abstract：:Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3709
更新日期：2014-06-01 00:00:00
abstract：:Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3773
更新日期：2014-09-01 00:00:00
abstract：:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2218
更新日期：2008-12-01 00:00:00
abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn985
更新日期：2003-01-01 00:00:00
abstract：:Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1023
更新日期：2003-04-01 00:00:00
abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3215
更新日期：2012-10-01 00:00:00
abstract：:Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-020-00715-2
更新日期：2020-11-01 00:00:00
abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:Uncovering the functional relationship between temporal lobe amnesia and diencephalic amnesia depends on determining the role of the fornix, the major interlinking fiber tract. In this study relating fornix volume with memory, we made magnetic resonance imaging-based volume estimates of 13 brain structures in 38 indiv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2149
更新日期：2008-07-01 00:00:00
abstract：:Axonal degeneration is important during development but has not been thought to function in the intact mature nervous system. Here, we provide evidence that degeneration of adult axons occurs in the intact rodent brain through a p75 neurotrophin receptor (p75NTR)- and myelin-dependent mechanism. Specifically, we show ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2513
更新日期：2010-05-01 00:00:00
abstract：:Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3853
更新日期：2014-12-01 00:00:00
abstract：:Hippocampal replay during sharp-wave ripple events (SWRs) is thought to drive memory consolidation in hippocampal and cortical circuits. Changes in neocortical activity can precede SWR events, but whether and how these changes influence the content of replay remains unknown. Here we show that during sleep there is a r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4457
更新日期：2017-02-01 00:00:00
abstract：:Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/2849
更新日期：1998-11-01 00:00:00
abstract：:Multiple protein kinase C (PKC) isozymes are present in neurons, where they regulate a variety of cellular functions. Due to the lack of specific PKC isozyme inhibitors, it remains unknown how PKC acts on its selective target(s) and achieves its specific actions. Here we show that a PKC binding protein, enigma homolog...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1041
更新日期：2003-05-01 00:00:00
abstract：:In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0111-7
更新日期：2018-06-01 00:00:00
abstract：:Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
doi：10.1038/85042
更新日期：2001-03-01 00:00:00
abstract：:The production of hippocampal granule neurons continues throughout adulthood but dramatically decreases in old age. Here we show that reducing corticosteroid levels in aged rats restored the rate of cell proliferation, resulting in increased numbers of new granule neurons. This result indicates that the neuronal precu...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/13197
更新日期：1999-10-01 00:00:00
abstract：:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1301
更新日期：2004-09-01 00:00:00
abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3857
更新日期：2014-12-01 00:00:00
abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn806
更新日期：2002-03-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3412
更新日期：2013-07-01 00:00:00
abstract：:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4413
更新日期：2016-11-01 00:00:00
abstract：:Many of the behavioral consequences of stress are mediated by the activation of the glucocorticoid receptor by stress-induced high levels of glucocorticoid hormones. To explore the molecular mechanisms of these effects, we combined in vivo and in vitro approaches. We analyzed mice carrying a brain-specific mutation (G...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1441
更新日期：2005-05-01 00:00:00
abstract：:Parkinson disease is a neurodegenerative disorder whose symptoms are caused by the loss of dopaminergic neurons innervating the striatum. As striatal dopamine levels fall, striatal acetylcholine release rises, exacerbating motor symptoms. This adaptation is commonly attributed to the loss of interneuronal regulation b...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1700
更新日期：2006-06-01 00:00:00
abstract：:Persistent neural activity in the absence of a stimulus has been identified as a neural correlate of working memory, but how such activity is maintained by neocortical circuits remains unknown. We used a computational approach to show that the inhibitory and excitatory microcircuitry of neocortical memory-storing regi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3492
更新日期：2013-09-01 00:00:00
abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/74865
更新日期：2000-05-01 00:00:00
abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/s41593-018-0250-x
更新日期：2018-10-01 00:00:00
