Using model systems to understand errant plasticity mechanisms in psychiatric disorders.

Abstract:

:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psychiatric disorders, there is less understanding of pathology at intervening levels of organization. Several psychiatric disorders derive from pathological neural plasticity, and studying the mechanisms that underlie these processes, including reinforcement learning and spike-timing-dependent plasticity, requires the use of animals. It will be particularly important to understand how individual differences in plasticity mechanisms at a cellular level confer resilience on some but lead to disease in others.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Averbeck BB,Chafee MV

doi

10.1038/nn.4413

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1418-1425

issue

11

eissn

1097-6256

issn

1546-1726

pii

nn.4413

journal_volume

19

pub_type

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