Abstract:
:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psychiatric disorders, there is less understanding of pathology at intervening levels of organization. Several psychiatric disorders derive from pathological neural plasticity, and studying the mechanisms that underlie these processes, including reinforcement learning and spike-timing-dependent plasticity, requires the use of animals. It will be particularly important to understand how individual differences in plasticity mechanisms at a cellular level confer resilience on some but lead to disease in others.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Averbeck BB,Chafee MVdoi
10.1038/nn.4413subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1418-1425issue
11eissn
1097-6256issn
1546-1726pii
nn.4413journal_volume
19pub_type
杂志文章,评审abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/79924
更新日期:2000-10-01 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3636
更新日期:2014-03-01 00:00:00
abstract::Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) intern...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3305
更新日期:2013-02-01 00:00:00
abstract::An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove rob...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2449
更新日期:2010-01-01 00:00:00
abstract::Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3131
更新日期:2012-06-03 00:00:00
abstract::Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record b...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3905
更新日期:2015-02-01 00:00:00
abstract::Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2192
更新日期:2008-10-01 00:00:00
abstract::The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4475
更新日期:2017-02-01 00:00:00
abstract::In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2289
更新日期:2009-04-01 00:00:00
abstract::Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/4553
更新日期:1999-01-01 00:00:00
abstract::It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2223
更新日期:2009-01-01 00:00:00
abstract::Bright objects capture our attention by virtue of 'popping out' from their surroundings. This correlates with strong responses in cortical areas thought to be important in attentional allocation. Previous studies have suggested that with the right mindset or training, humans can ignore popout stimuli. We studied the a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1734
更新日期:2006-08-01 00:00:00
abstract::Dot patterns sliding transparently across one another are normally perceived as independently moving surfaces. Recordings from direction-selective neurons in area MT of the macaque suggested that this perceptual segregation did not depend on the presence of two peaks in the population activity. Rather, the visual syst...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72985
更新日期:2000-03-01 00:00:00
abstract::Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2644
更新日期:2010-11-01 00:00:00
abstract::Cognition can be conceptualized as a set of algorithmic control functions whose real-time deployment determines how an organism stores and uses information to guide thought and action. A subset of these functions is required for goal-directed selection and amplification of sensory signals-broadly referred to as attent...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/s41593-017-0020-1
更新日期:2017-12-01 00:00:00
abstract::Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3407
更新日期:2013-07-01 00:00:00
abstract::Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3773
更新日期:2014-09-01 00:00:00
abstract::The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4350
更新日期:2016-09-01 00:00:00
abstract::In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2005
更新日期:2007-12-01 00:00:00
abstract::Ability to integrate diverse forms of information in current thought, or working memory, is essential for human reasoning and problem solving. We used functional imaging to identify brain regions preferentially involved in maintaining integrated versus unintegrated information in working memory. For equal amounts of v...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章
doi:10.1038/71156
更新日期:2000-01-01 00:00:00
abstract::A moving grating elicits innate optomotor behavior in zebrafish larvae; they swim in the direction of perceived motion. We took advantage of this behavior, using computer-animated displays, to determine what attributes of motion are extracted by the fish visual system. As in humans, first-order (luminance-defined or F...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/80649
更新日期:2000-11-01 00:00:00
abstract::Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nuc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1949
更新日期:2007-09-01 00:00:00
abstract::Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/13149
更新日期:1999-10-01 00:00:00
abstract::Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2076
更新日期:2008-04-01 00:00:00
abstract::How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit function? Experimental work shows that these properties vary considerably across identified neurons in different animals. Given this variability in experimental data, this review describes some of the complications of buil...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2735
更新日期:2011-02-01 00:00:00
abstract::EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3249
更新日期:2012-12-01 00:00:00
abstract::At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically ac...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1450
更新日期:2005-05-01 00:00:00
abstract::In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic (intraperitoneal) administration. The error has been corrected in the HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0111-7
更新日期:2018-06-01 00:00:00
abstract::The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/85090
更新日期:2001-03-01 00:00:00