Abstract:
:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
doi
10.1038/s41593-018-0250-xsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
1293issue
10eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0250-xjournal_volume
21pub_type
社论abstract::In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0317-8
更新日期:2019-03-01 00:00:00
abstract::Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cort...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0094-4
更新日期:2018-04-01 00:00:00
abstract::Arcuate nucleus (ARC) neurons sense the fed or fasted state and regulate hunger. Agouti-related protein (AgRP) neurons in the ARC (ARCAgRP neurons) are stimulated by fasting and, once activated, they rapidly (within minutes) drive hunger. Pro-opiomelanocortin (ARCPOMC) neurons are viewed as the counterpoint to ARCAgRP...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4442
更新日期:2017-01-01 00:00:00
abstract::Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2816
更新日期:2011-06-01 00:00:00
abstract::Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1805
更新日期:2006-12-01 00:00:00
abstract::We studied how the posterior parietal cortex combines new information with ongoing activity dynamics as mice accumulate evidence during a virtual navigation task. Using new methods to analyze population activity on single trials, we found that activity transitioned rapidly between different sets of active neurons. Eac...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4403
更新日期:2016-12-01 00:00:00
abstract::Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn945
更新日期:2002-11-01 00:00:00
abstract::Behavior-contingent network oscillations bring about transient, functionally coherent neuronal assemblies in the cerebral cortex, including the hippocampus. Inhibitory input on and close to the soma is believed to phase intrinsic oscillations and output of pyramidal cells, but the function of GABA release to pyramidal...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1159
更新日期:2004-01-01 00:00:00
abstract::The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4086
更新日期:2015-10-01 00:00:00
abstract::We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1780
更新日期:2006-11-01 00:00:00
abstract::Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3785
更新日期:2014-09-01 00:00:00
abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3625
更新日期:2014-02-01 00:00:00
abstract::We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles for it in patterning mammalian neocortex into areas. The highest COUP-TFI expression is observed in the cortical progenitors and progeny in parietal and occipital...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1958
更新日期:2007-10-01 00:00:00
abstract::Recent evidence suggests that presynaptic-acting NMDA receptors (preNMDARs) are important for neocortical synaptic transmission and plasticity. We found that unique properties of the NR3A subunit enable preNMDARs to enhance spontaneous and evoked glutamate release and that NR3A is required for spike timing-dependent l...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2750
更新日期:2011-03-01 00:00:00
abstract::Neurotransmitters are released continuously at ribbon synapses in the retina and cochlea. Notably, a single ribbon synapse of inner hair cells provides the entire input to each cochlear afferent fiber. We investigated hair cell transmitter release in the postnatal rat cochlea by recording excitatory postsynaptic curre...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn796
更新日期:2002-02-01 00:00:00
abstract::Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4553
更新日期:2017-06-01 00:00:00
abstract::Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment de...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2647
更新日期:2010-10-01 00:00:00
abstract::We report on two brain-damaged subjects who exhibit the uncommon pattern of loss of object color knowledge, but spared color perception and naming. The subject P.C.O., as in previously reported patients, is also impaired in processing other perceptual and functional properties of objects. I.O.C., in contrast, is the f...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/88497
更新日期:2001-06-01 00:00:00
abstract::Neuronal signaling occurs through both action potential-triggered synaptic vesicle fusion and spontaneous release, although the fusion clamp machinery that prevents premature exocytosis of synaptic vesicles in the absence of calcium is unknown. Here we demonstrate that spontaneous release at synapses is regulated by c...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1980
更新日期:2007-10-01 00:00:00
abstract::Imaging, from magnetic resonance imaging (MRI) to localization of specific macromolecules by microscopies, has been one of the driving forces behind neuroinformatics efforts of the past decade. Many web-accessible resources have been created, ranging from simple data collections to highly structured databases. Althoug...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1229
更新日期:2004-05-01 00:00:00
abstract::Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3853
更新日期:2014-12-01 00:00:00
abstract::Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1322
更新日期:2004-10-01 00:00:00
abstract::Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3059
更新日期:2012-03-04 00:00:00
abstract::Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1417
更新日期:2005-04-01 00:00:00
abstract::We demonstrate a form of long-term depression (LTD) in the perirhinal cortex that relies on interaction between different glutamate receptors. Group II metabotropic glutamate (mGlu) receptors facilitated group I mGlu receptor-mediated increases in intracellular calcium. This facilitation plus NMDA receptor activation ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/72093
更新日期:2000-02-01 00:00:00
abstract::Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure, the perineurium, which ensheaths the motor nerve, forming a flexible, protective barrier. Consequently, the origin of p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2025
更新日期:2008-02-01 00:00:00
abstract::Cell type-specific expression of optogenetic molecules allows temporally precise manipulation of targeted neuronal activity. Here we present a toolbox of four knock-in mouse lines engineered for strong, Cre-dependent expression of channelrhodopsins ChR2-tdTomato and ChR2-EYFP, halorhodopsin eNpHR3.0 and archaerhodopsi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3078
更新日期:2012-03-25 00:00:00
abstract::The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1182
更新日期:2004-02-01 00:00:00
abstract::Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/6368
更新日期:1999-03-01 00:00:00
abstract::Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/74865
更新日期:2000-05-01 00:00:00