Abstract：
:Items held in working memory can be either attended or not, depending on their current behavioral relevance. It has been suggested that unattended contents might be solely retained in an activity-silent form. Instead, we demonstrate here that encoding unattended contents involves a division of labor. While visual cortex only maintains attended items, intraparietal areas and the frontal eye fields represent both attended and unattended items.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Christophel TB,Iamshchinina P,Yan C,Allefeld C,Haynes JDdoi
10.1038/s41593-018-0094-4subject
Has Abstractpub_date
2018-04-01 00:00:00pages
494-496issue
4eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0094-4journal_volume
21pub_type
杂志文章abstract：:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2218
更新日期：2008-12-01 00:00:00
abstract：:Olfaction has often been described as a ‘synthetic’ sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn.3796
更新日期：2014-09-01 00:00:00
abstract：:The precise period when experience shapes neural circuits in the mouse visual system is unknown. We used Arc induction to monitor the functional pattern of ipsilateral eye representation in cortex during normal development and after visual deprivation. After monocular deprivation during the critical period, Arc induct...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1410
更新日期：2005-03-01 00:00:00
abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0075-7
更新日期：2018-03-01 00:00:00
abstract：:Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3604
更新日期：2014-03-01 00:00:00
abstract：:The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
doi：10.1038/nn0908-989
更新日期：2008-09-01 00:00:00
abstract：:Ample evidence suggests that primary visual cortex is involved in the perception of form, and there is increasing evidence that it may also be important in the perception of surfaces. Perceptual qualities of surfaces, such as brightness, are based on extensive integration of information throughout the visual field. In...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/2849
更新日期：1998-11-01 00:00:00
abstract：:Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2264
更新日期：2009-03-01 00:00:00
abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3131
更新日期：2012-06-03 00:00:00
abstract：:The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn1083
更新日期：2003-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-020-0595-9
更新日期：2020-02-01 00:00:00
abstract：:Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title：Nature neuroscience
pub_type： 社论
doi：10.1038/s41593-018-0250-x
更新日期：2018-10-01 00:00:00
abstract：:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protei...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3280
更新日期：2013-01-01 00:00:00
abstract：:Contrast is computed throughout the nervous system to encode changing inputs efficiently. The retina encodes luminance and contrast over a wide range of visual conditions and must adapt its responses to maintain sensitivity and to avoid saturation. We examined the means by which one type of adaptation allows individua...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2945
更新日期：2011-10-23 00:00:00
abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0181-6
更新日期：2018-09-01 00:00:00
abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3348
更新日期：2013-04-01 00:00:00
abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2318
更新日期：2009-05-01 00:00:00
abstract：:To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant excess of rare protein-truncating variants among ALS cases, and these variants were concentrated in constrained genes. Through gene level analyses...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0530-0
更新日期：2019-12-01 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1300
更新日期：2004-09-01 00:00:00
abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/nn0910-1039
更新日期：2010-09-01 00:00:00
abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2146
更新日期：2008-07-01 00:00:00
abstract：:We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3843
更新日期：2014-12-01 00:00:00
abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/12186
更新日期：1999-09-01 00:00:00
abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4267
更新日期：2016-04-01 00:00:00
abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/14801
更新日期：1999-11-01 00:00:00
abstract：:Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous cell population in biophysical, pharmacological and modeling studies. We found robust differences between pyramidal neurons residing in the deep and superficial CA1 sublayers in rats. Compared with their superficial peers, deep pyramidal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2894
更新日期：2011-08-07 00:00:00
abstract：:An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/89522
更新日期：2001-07-01 00:00:00
abstract：:Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm and the nucleus. We demo...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1134
更新日期：2003-11-01 00:00:00
abstract：:The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4285
更新日期：2016-05-01 00:00:00
abstract：:Relative quiescence and self renewal are defining features of adult stem cells, but their potential coordination remains unclear. Subependymal neural stem cells (NSCs) lacking cyclin-dependent kinase (CDK) inhibitor (CKI) 1a (p21) exhibit rapid expansion that is followed by their permanent loss later in life. Here we ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3545
更新日期：2013-11-01 00:00:00
