E-neuroscience: challenges and triumphs in integrating distributed data from molecules to brains.

abstract：:A central question in the study of human behavior is the origin of willed action. EEG recordings of surface brain activity from human subjects performing a self-initiated movement show that the subjective experience of wanting to move follows, rather than precedes, the 'readiness potential'--an electrophysiological ma...

journal_title：Nature neuroscience

authors： Sirigu A,Daprati E,Ciancia S,Giraux P,Nighoghossian N,Posada A,Haggard P

更新日期：2004-01-01 00:00:00

abstract：:Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex...

journal_title：Nature neuroscience

authors： Ranganathan GN,Apostolides PF,Harnett MT,Xu NL,Druckmann S,Magee JC

更新日期：2018-11-01 00:00:00

abstract：:Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...

journal_title：Nature neuroscience

authors： Dietz DM,Sun H,Lobo MK,Cahill ME,Chadwick B,Gao V,Koo JW,Mazei-Robison MS,Dias C,Maze I,Damez-Werno D,Dietz KC,Scobie KN,Ferguson D,Christoffel D,Ohnishi Y,Hodes GE,Zheng Y,Neve RL,Hahn KM,Russo SJ,Nestler EJ

更新日期：2012-06-01 00:00:00

abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...

journal_title：Nature neuroscience

authors： Yasuda H,Barth AL,Stellwagen D,Malenka RC

更新日期：2003-01-01 00:00:00

abstract：:The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...

journal_title：Nature neuroscience

authors： Pack-Chung E,Kurshan PT,Dickman DK,Schwarz TL

更新日期：2007-08-01 00:00:00

abstract：:Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...

journal_title：Nature neuroscience

authors： Nevian T,Larkum ME,Polsky A,Schiller J

更新日期：2007-02-01 00:00:00

abstract：:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortica...

journal_title：Nature neuroscience

authors： Reyes A,Lujan R,Rozov A,Burnashev N,Somogyi P,Sakmann B

更新日期：1998-08-01 00:00:00

abstract：:EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...

journal_title：Nature neuroscience

authors： Carvalho RF,Beutler M,Marler KJ,Knöll B,Becker-Barroso E,Heintzmann R,Ng T,Drescher U

更新日期：2006-03-01 00:00:00

abstract：:We used ultrasound image-guided injections of high-titer retroviral vectors to obtain widespread introduction of genes into the mouse nervous system in utero as early as embryonic day 8.5 (E8.5). The vectors used included internal promoters that substantially improved proviral gene expression in the ventricular zone o...

journal_title：Nature neuroscience

authors： Gaiano N,Kohtz JD,Turnbull DH,Fishell G

更新日期：1999-09-01 00:00:00

abstract：:Dendritic spines are motile structures that contain high concentrations of filamentous actin. Using hippocampal neurons expressing fluorescent actin and the method of fluorescence recovery after photobleaching, we found that 85 +/- 2% of actin in the spine was dynamic, with a turnover time of 44.2 +/- 4.0 s. The rapid...

journal_title：Nature neuroscience

authors： Star EN,Kwiatkowski DJ,Murthy VN

更新日期：2002-03-01 00:00:00

abstract：:The neural mechanisms that mediate the transition from a drug-naive state to a state of drug dependence and addiction are not yet known. Here we show that a discrete population of GABA(A) receptors in the mammalian ventral tegmental area (VTA) serves as a potential addiction switching mechanism by gating reward transm...

journal_title：Nature neuroscience

authors： Laviolette SR,Gallegos RA,Henriksen SJ,van der Kooy D

更新日期：2004-02-01 00:00:00

abstract：:En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a ...

journal_title：Nature neuroscience

authors： Zhang J,Lefebvre JL,Zhao S,Granato M

更新日期：2004-12-01 00:00:00

abstract：:The CNS, which consists of the brain and spinal cord, is continuously monitored by resident microglia and blood-borne immune cells such as macrophages, dendritic cells and T cells to detect for damaging agents that would disrupt homeostasis and optimal functioning of these vital organs. Further, the CNS must balance b...

journal_title：Nature neuroscience

authors： Ousman SS,Kubes P

更新日期：2012-07-26 00:00:00

abstract：:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to m...

journal_title：Nature neuroscience

authors： Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

更新日期：2015-09-01 00:00:00

abstract：:Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting that both the identity of activated neurons and the timing of their activity convey information about odors. However, whether and how downstream neurons decipher these temporal patterns remains unknown. We addressed this question...

journal_title：Nature neuroscience

authors： Haddad R,Lanjuin A,Madisen L,Zeng H,Murthy VN,Uchida N

更新日期：2013-07-01 00:00:00

abstract：:Much of the information processing in the brain occurs at the level of local circuits; however, the mechanisms underlying their initial development are poorly understood. We sought to examine the early development and plasticity of local excitatory circuits in the optic tectum of Xenopus laevis tadpoles. We found that...

journal_title：Nature neuroscience

authors： Pratt KG,Dong W,Aizenman CD

更新日期：2008-04-01 00:00:00

abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...

journal_title：Nature neuroscience

authors： Rolfs M,Jonikaitis D,Deubel H,Cavanagh P

更新日期：2011-02-01 00:00:00

abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...

journal_title：Nature neuroscience

authors： Sanchez-Padilla J,Guzman JN,Ilijic E,Kondapalli J,Galtieri DJ,Yang B,Schieber S,Oertel W,Wokosin D,Schumacker PT,Surmeier DJ

更新日期：2014-06-01 00:00:00

abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...

journal_title：Nature neuroscience

authors： Gal E,London M,Globerson A,Ramaswamy S,Reimann MW,Muller E,Markram H,Segev I

更新日期：2017-07-01 00:00:00

abstract：:The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated viruses (AAV) expressing malonyl-coenzyme A decarboxylase (MCD; an enzyme involved in the degradation of malonyl coenzyme A...

journal_title：Nature neuroscience

authors： He W,Lam TK,Obici S,Rossetti L

更新日期：2006-02-01 00:00:00

abstract：:Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...

journal_title：Nature neuroscience

authors： Bollmann JH,Sakmann B

更新日期：2005-04-01 00:00:00

abstract：:Candidate Drosophila olfactory receptors (ORs) provide molecular tools to investigate how the organization of the Drosophila olfactory system determines the coding of olfactory stimuli. Neurons in the third antennal segment and maxillary palp appear to express different ORs. Individual olfactory neurons send axonal pr...

journal_title：Nature neuroscience

authors： Gao Q,Yuan B,Chess A

更新日期：2000-08-01 00:00:00

abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

journal_title：Nature neuroscience

authors： Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

更新日期：2007-06-01 00:00:00

abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...

journal_title：Nature neuroscience

authors： Wolpert DM,Ghahramani Z

更新日期：2000-11-01 00:00:00

abstract：:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protei...

journal_title：Nature neuroscience

authors： Vassoler FM,White SL,Schmidt HD,Sadri-Vakili G,Pierce RC

更新日期：2013-01-01 00:00:00

abstract：:Humans, and animals, often encounter ambiguous situations that require a decision on whether to take an offense or a defense strategy. Behavioral studies suggest that a strategy decision is frequently made before concrete options are evaluated. It remains enigmatic, however, how a strategy is determined without explor...

journal_title：Nature neuroscience

authors： Wan X,Cheng K,Tanaka K

更新日期：2015-05-01 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal r...

journal_title：Nature neuroscience

authors： Lorber B,Howe ML,Benowitz LI,Irwin N

更新日期：2009-11-01 00:00:00

abstract：:Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure, the perineurium, which ensheaths the motor nerve, forming a flexible, protective barrier. Consequently, the origin of p...

journal_title：Nature neuroscience

authors： Kucenas S,Takada N,Park HC,Woodruff E,Broadie K,Appel B

更新日期：2008-02-01 00:00:00

abstract：:Binocular competition is thought to drive eye-specific segregation in the developing visual system, potentially through Hebbian synaptic learning rules that are sensitive to correlations in afferent activity. Altering retinal activity can disrupt eye-specific segregation, but little is known about the temporal feature...

journal_title：Nature neuroscience

authors： Zhang J,Ackman JB,Xu HP,Crair MC

更新日期：2011-11-18 00:00:00