Abstract：
:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protein were increased in the medial prefrontal cortex (mPFC), and there was an increased association of acetylated histone H3 with Bdnf promoters in only the male offspring of cocaine-experienced sires. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats. In addition, the association of acetylated histone H3 with Bdnf promoters was increased in the sperm of sires that self-administered cocaine. Collectively, these findings indicate that voluntary paternal ingestion of cocaine results in epigenetic reprogramming of the germline, having profound effects on mPFC gene expression and resistance to cocaine reinforcement in male offspring.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Vassoler FM,White SL,Schmidt HD,Sadri-Vakili G,Pierce RCdoi
10.1038/nn.3280subject
Has Abstractpub_date
2013-01-01 00:00:00pages
42-7issue
1eissn
1097-6256issn
1546-1726pii
nn.3280journal_volume
16pub_type
杂志文章abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2192
更新日期：2008-10-01 00:00:00
abstract：:Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1086
更新日期：2003-08-01 00:00:00
abstract：:In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained com...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0317-8
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abstract：:Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in est...
journal_title：Nature neuroscience
pub_type： 评论,新闻
doi：10.1038/nn0910-1039
更新日期：2010-09-01 00:00:00
abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn884
更新日期：2002-08-01 00:00:00
abstract：:Head-direction cells have frequently been regarded as an internal 'compass' that can be used for navigation, although there is little evidence showing a link between their activity and spatial behavior. In a navigational task requiring the use of internal cues to return to a home location without vision (path integrat...
journal_title：Nature neuroscience
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pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 评论,新闻
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abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2901
更新日期：2011-09-11 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2002-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1845
更新日期：2007-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00752-x
更新日期：2021-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4378
更新日期：2016-09-27 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1441
更新日期：2005-05-01 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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doi：10.1038/nn.3796
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journal_title：Nature neuroscience
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更新日期：2008-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 已发布勘误
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更新日期：2019-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
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更新日期：2001-01-01 00:00:00
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更新日期：2011-10-23 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2005-05-01 00:00:00
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journal_title：Nature neuroscience
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