Abstract:
:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral immune system, perhaps affecting autoimmunity. Here we demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner. Unlike other tissues, meningeal lymphatic endothelial cells do not undergo expansion during inflammation, and they express a unique transcriptional signature. Notably, the ablation of meningeal lymphatics diminishes pathology and reduces the inflammatory response of brain-reactive T cells during an animal model of multiple sclerosis. Our findings demonstrate that meningeal lymphatics govern inflammatory processes and immune surveillance of the CNS and pose a valuable target for therapeutic intervention.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis Jdoi
10.1038/s41593-018-0227-9subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1380-1391issue
10eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0227-9journal_volume
21pub_type
杂志文章abstract::Economic choice entails assigning values to the available options and is impaired by lesions to the orbitofrontal cortex (OFC). Recent results show that some neurons in the OFC encode the values that monkeys (Macaca mulatta) assign to different goods when they choose between them. A broad and fundamental question is h...
journal_title:Nature neuroscience
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
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journal_title:Nature neuroscience
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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更新日期:2015-09-01 00:00:00
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