Abstract：
:A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation. Here we show that the regulatory subunits of PKA are colocalized with AKAP150 (an AKAP isoform that is expressed in the brain) in the lateral amygdala (LA) and that infusion to the LA of the peptide St-Ht31, which blocks PKA anchoring onto AKAPs, impairs memory consolidation of auditory fear conditioning.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Moita MA,Lamprecht R,Nader K,LeDoux JEdoi
10.1038/nn901subject
Has Abstractpub_date
2002-09-01 00:00:00pages
837-8issue
9eissn
1097-6256issn
1546-1726pii
nn901journal_volume
5pub_type
杂志文章abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...
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