A system in the human brain for predicting the actions of others.

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:Humans and other primates sample the visual environment using saccadic eye movements that shift a high-resolution fovea toward regions of interest to create a clear perception of a scene across fixations. Many mammals, however, like mice, lack a fovea, which raises the question of why they make saccades. Here we descr...

journal_title：Nature neuroscience

authors： Samonds JM,Geisler WS,Priebe NJ

更新日期：2018-11-01 00:00:00

abstract：:Agonists of GABA(B) receptors exert a bi-directional effect on the activity of dopamine (DA) neurons of the ventral tegmental area, which can be explained by the fact that coupling between GABA(B) receptors and G protein-gated inwardly rectifying potassium (GIRK) channels is significantly weaker in DA neurons than in ...

journal_title：Nature neuroscience

authors： Labouèbe G,Lomazzi M,Cruz HG,Creton C,Luján R,Li M,Yanagawa Y,Obata K,Watanabe M,Wickman K,Boyer SB,Slesinger PA,Lüscher C

更新日期：2007-12-01 00:00:00

abstract：:Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related ...

journal_title：Nature neuroscience

authors： Rao SM,Mayer AR,Harrington DL

更新日期：2001-03-01 00:00:00

abstract：:Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

journal_title：Nature neuroscience

authors： Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

更新日期：2017-01-01 00:00:00

abstract：:In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as neurons differentiated from induced plurip...

journal_title：Nature neuroscience

authors： Victor MB,Richner M,Olsen HE,Lee SW,Monteys AM,Ma C,Huh CJ,Zhang B,Davidson BL,Yang XW,Yoo AS

更新日期：2018-03-01 00:00:00

abstract：:Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...

journal_title：Nature neuroscience

authors： Xie Q,Wu Q,Horbinski CM,Flavahan WA,Yang K,Zhou W,Dombrowski SM,Huang Z,Fang X,Shi Y,Ferguson AN,Kashatus DF,Bao S,Rich JN

更新日期：2015-04-01 00:00:00

abstract：:Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...

journal_title：Nature neuroscience

authors： Meyer-Lindenberg A,Kohn PD,Kolachana B,Kippenhan S,McInerney-Leo A,Nussbaum R,Weinberger DR,Berman KF

更新日期：2005-05-01 00:00:00

abstract：:In the postnatal subventricular zone (SVZ), local cues or signaling molecules released from neuroblasts limit the proliferation of glial fibrillary acidic protein (GFAP)-expressing progenitors thought to be stem cells. However, signals between SVZ cells have not been identified. We show that depolarization of neurobla...

journal_title：Nature neuroscience

authors： Liu X,Wang Q,Haydar TF,Bordey A

更新日期：2005-09-01 00:00:00

abstract：:Brain neural stem cells (radial glial progenitors, RGPs) undergo a mysterious form of cell cycle-entrained interkinetic nuclear migration (INM) that is driven apically by cytoplasmic dynein and basally by the kinesin KIF1A, which has recently been implicated in human brain developmental disease. To understand the cons...

journal_title：Nature neuroscience

authors： Carabalona A,Hu DJ,Vallee RB

更新日期：2016-02-01 00:00:00

abstract：:The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in ...

journal_title：Nature neuroscience

authors： Regad T,Bellodi C,Nicotera P,Salomoni P

更新日期：2009-02-01 00:00:00

abstract：:In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cin...

journal_title：Nature neuroscience

authors： Narayanan NS,Cavanagh JF,Frank MJ,Laubach M

更新日期：2013-12-01 00:00:00

abstract：:Human observers adapted to complex biological motions that distinguish males from females: viewing the gait of one gender biased judgments of subsequent gaits toward the opposite gender. This adaptation was not simply due to local features of the stimuli but instead relied upon the global motion of the figures. These ...

journal_title：Nature neuroscience

authors： Jordan H,Fallah M,Stoner GR

更新日期：2006-06-01 00:00:00

abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...

journal_title：Nature neuroscience

authors： Williams KW,Elmquist JK

更新日期：2012-10-01 00:00:00

abstract：:We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protei...

journal_title：Nature neuroscience

authors： Vassoler FM,White SL,Schmidt HD,Sadri-Vakili G,Pierce RC

更新日期：2013-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...

journal_title：Nature neuroscience

authors： Chesi A,Staahl BT,Jovičić A,Couthouis J,Fasolino M,Raphael AR,Yamazaki T,Elias L,Polak M,Kelly C,Williams KL,Fifita JA,Maragakis NJ,Nicholson GA,King OD,Reed R,Crabtree GR,Blair IP,Glass JD,Gitler AD

更新日期：2013-07-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Marek R,Jin J,Goode TD,Giustino TF,Wang Q,Acca GM,Holehonnur R,Ploski JE,Fitzgerald PJ,Lynagh T,Lynch JW,Maren S,Sah P

更新日期：2018-09-01 00:00:00

abstract：:Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...

journal_title：Nature neuroscience

authors： Urbanczik R,Senn W

更新日期：2009-03-01 00:00:00

abstract：:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...

journal_title：Nature neuroscience

authors： Mameli M,Bellone C,Brown MT,Lüscher C

更新日期：2011-04-01 00:00:00

abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...

journal_title：Nature neuroscience

authors： Huang J,Polgár E,Solinski HJ,Mishra SK,Tseng PY,Iwagaki N,Boyle KA,Dickie AC,Kriegbaum MC,Wildner H,Zeilhofer HU,Watanabe M,Riddell JS,Todd AJ,Hoon MA

更新日期：2018-05-01 00:00:00

abstract：:Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...

journal_title：Nature neuroscience

authors： Lee S,Song B,Kim J,Park K,Hong I,An B,Song S,Lee J,Park S,Kim J,Park D,Lee CJ,Kim K,Shin KS,Tsien RW,Choi S

更新日期：2013-10-01 00:00:00

abstract：:Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...

journal_title：Nature neuroscience

authors： Hardingham GE,Fukunaga Y,Bading H

更新日期：2002-05-01 00:00:00

abstract：:Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link ...

journal_title：Nature neuroscience

authors： Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

更新日期：2018-10-01 00:00:00

abstract：:The autosomal dominant disorder neurofibromatosis type 2 (NF2) is a hereditary tumor syndrome caused by inactivation of the NF2 tumor suppressor gene, encoding merlin. Apart from tumors affecting the peripheral and central nervous systems, most NF2 patients develop peripheral neuropathies. This peripheral nerve diseas...

journal_title：Nature neuroscience

authors： Schulz A,Baader SL,Niwa-Kawakita M,Jung MJ,Bauer R,Garcia C,Zoch A,Schacke S,Hagel C,Mautner VF,Hanemann CO,Dun XP,Parkinson DB,Weis J,Schröder JM,Gutmann DH,Giovannini M,Morrison H

更新日期：2013-04-01 00:00:00

abstract：:The mechanism by which adult neural stem cells (NSCs) are established during development is unclear. In this study, analysis of cell cycle progression by examining retention of a histone 2B (H2B)-GFP fusion protein revealed that, in a subset of mouse embryonic neural progenitor cells (NPCs), the cell cycle slows betwe...

journal_title：Nature neuroscience

authors： Furutachi S,Miya H,Watanabe T,Kawai H,Yamasaki N,Harada Y,Imayoshi I,Nelson M,Nakayama KI,Hirabayashi Y,Gotoh Y

更新日期：2015-05-01 00:00:00

abstract：:The music faculty is not a monolithic entity that a person either has or does not. Rather, it comprises a set of neurally isolable processing components, each having the potential to be specialized for music. Here we propose a functional architecture for music processing that captures the typical properties of modular...

journal_title：Nature neuroscience

authors： Peretz I,Coltheart M

更新日期：2003-07-01 00:00:00

abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...

journal_title：Nature neuroscience

authors： Kisler K,Nelson AR,Rege SV,Ramanathan A,Wang Y,Ahuja A,Lazic D,Tsai PS,Zhao Z,Zhou Y,Boas DA,Sakadžić S,Zlokovic BV

更新日期：2017-03-01 00:00:00

abstract：:Human neurodegenerative disorders are among the most difficult to study. In particular, the inability to readily obtain the faulty cell types most relevant to these diseases has impeded progress for decades. Recent advances in pluripotent stem cell technology now grant access to substantial quantities of disease-perti...

journal_title：Nature neuroscience

authors： Sandoe J,Eggan K

更新日期：2013-07-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...

journal_title：Nature neuroscience

authors： Phan BN,Bohlen JF,Davis BA,Ye Z,Chen HY,Mayfield B,Sripathy SR,Cerceo Page S,Campbell MN,Smith HL,Gallop D,Kim H,Thaxton CL,Simon JM,Burke EE,Shin JH,Kennedy AJ,Sweatt JD,Philpot BD,Jaffe AE,Maher BJ

更新日期：2020-03-01 00:00:00