Common medial frontal mechanisms of adaptive control in humans and rodents.

abstract：:Many attempts to obtain reliable self-administration behavior by laboratory animals with delta-9-tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana, have been unsuccessful. Because self-administration behavior has been demonstrated in laboratory animals for almost all other psychoactive drugs abused ...

journal_title：Nature neuroscience

authors： Tanda G,Munzar P,Goldberg SR

更新日期：2000-11-01 00:00:00

abstract：:Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly...

journal_title：Nature neuroscience

authors： Wu LJ,Wu G,Akhavan Sharif MR,Baker A,Jia Y,Fahey FH,Luo HR,Feener EP,Clapham DE

更新日期：2012-03-04 00:00:00

abstract：:Neuroimaging studies show that the efficacy of long-term memory encoding of a stimulus is indexed by transient neural activity elicited by that stimulus. Here, we show that successful memory encoding is also indexed by neural activity that is tonically maintained throughout a study task. Using functional magnetic reso...

journal_title：Nature neuroscience

authors： Otten LJ,Henson RN,Rugg MD

更新日期：2002-12-01 00:00:00

abstract：:Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, most published work focuses on correl...

journal_title：Nature neuroscience

authors： Russo SJ,Murrough JW,Han MH,Charney DS,Nestler EJ

更新日期：2012-11-01 00:00:00

abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...

journal_title：Nature neuroscience

authors： Cavanagh P,Hénaff MA,Michel F,Landis T,Troscianko T,Intriligator J

更新日期：1998-07-01 00:00:00

abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...

journal_title：Nature neuroscience

authors： Homan P,Levy I,Feltham E,Gordon C,Hu J,Li J,Pietrzak RH,Southwick S,Krystal JH,Harpaz-Rotem I,Schiller D

更新日期：2019-03-01 00:00:00

abstract：:Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...

journal_title：Nature neuroscience

authors： Urbanczik R,Senn W

更新日期：2009-03-01 00:00:00

abstract：:We found that K(+)/Cl(-) co-transporter 2 (KCC2) activity, monitored with wide-field fluorescence, was inhibited by intracellular Zn(2+), a major component of neuronal injury. Zn(2+)-mediated KCC2 inhibition produced a depolarizing shift of GABA(A) reversal potentials in rat cortical neurons. Moreover, oxygen-glucose ...

journal_title：Nature neuroscience

authors： Hershfinkel M,Kandler K,Knoch ME,Dagan-Rabin M,Aras MA,Abramovitch-Dahan C,Sekler I,Aizenman E

更新日期：2009-06-01 00:00:00

abstract：:All the higher mental and cognitive functions unique to humans depend on the neocortex ('new' cortex, referring to its relatively recent appearance in evolution), which is divided into discrete areas that subserve distinct functions, such as language, movement and sensation. With a few notable exceptions, all neocorti...

journal_title：Nature neuroscience

authors： Monuki ES,Walsh CA

更新日期：2001-11-01 00:00:00

abstract：:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...

journal_title：Nature neuroscience

authors： Burgos-Robles A,Kimchi EY,Izadmehr EM,Porzenheim MJ,Ramos-Guasp WA,Nieh EH,Felix-Ortiz AC,Namburi P,Leppla CA,Presbrey KN,Anandalingam KK,Pagan-Rivera PA,Anahtar M,Beyeler A,Tye KM

更新日期：2017-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers...

journal_title：Nature neuroscience

authors： Bibel M,Richter J,Schrenk K,Tucker KL,Staiger V,Korte M,Goetz M,Barde YA

更新日期：2004-09-01 00:00:00

abstract：:Major, rapid performance improvements in perceptual training are often dismissed as 'task' or 'procedural' learning because they are fast and generalize within a task. We assessed the contributions of perceptual and procedural learning to improvement in an auditory tone frequency learning task in humans and found that...

journal_title：Nature neuroscience

authors： Hawkey DJ,Amitay S,Moore DR

更新日期：2004-10-01 00:00:00

abstract：:Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. ...

journal_title：Nature neuroscience

authors： Tost H,Reichert M,Braun U,Reinhard I,Peters R,Lautenbach S,Hoell A,Schwarz E,Ebner-Priemer U,Zipf A,Meyer-Lindenberg A

更新日期：2019-09-01 00:00:00

abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...

journal_title：Nature neuroscience

authors： Graziane NM,Sun S,Wright WJ,Jang D,Liu Z,Huang YH,Nestler EJ,Wang YT,Schlüter OM,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci within minutes of neuronal activation and subsequently disappeared from the nucleus and accumulated in the cytoplasm by 30 minutes. T...

journal_title：Nature neuroscience

authors： Guzowski JF,McNaughton BL,Barnes CA,Worley PF

更新日期：1999-12-01 00:00:00

abstract：:The accessory olfactory bulb (AOB) is a critical olfactory structure that has been implicated in mediating social behavior. It receives input from the vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior and posterior components (aAOB and pAOB) display molecular, connectional and functiona...

journal_title：Nature neuroscience

authors： Huilgol D,Udin S,Shimogori T,Saha B,Roy A,Aizawa S,Hevner RF,Meyer G,Ohshima T,Pleasure SJ,Zhao Y,Tole S

更新日期：2013-02-01 00:00:00

abstract：:Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly susceptible to disruptions of the secretory pathway. Endoplasmic reticulum stress, initiated by the accumulation of un...

journal_title：Nature neuroscience

authors： Lin W,Popko B

更新日期：2009-04-01 00:00:00

abstract：:The molecular basis of CNS myelin regeneration (remyelination) is poorly understood. We generated a comprehensive transcriptional profile of the separate stages of spontaneous remyelination that follow focal demyelination in the rat CNS and found that transcripts that encode the retinoid acid receptor RXR-γ were diffe...

journal_title：Nature neuroscience

authors： Huang JK,Jarjour AA,Nait Oumesmar B,Kerninon C,Williams A,Krezel W,Kagechika H,Bauer J,Zhao C,Baron-Van Evercooren A,Chambon P,Ffrench-Constant C,Franklin RJM

更新日期：2011-01-01 00:00:00

abstract：:Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, ...

journal_title：Nature neuroscience

authors： Miller KL,Alfaro-Almagro F,Bangerter NK,Thomas DL,Yacoub E,Xu J,Bartsch AJ,Jbabdi S,Sotiropoulos SN,Andersson JL,Griffanti L,Douaud G,Okell TW,Weale P,Dragonu I,Garratt S,Hudson S,Collins R,Jenkinson M,Matthews PM,

更新日期：2016-11-01 00:00:00

abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...

journal_title：Nature neuroscience

authors： Happé F,Ronald A,Plomin R

更新日期：2006-10-01 00:00:00

abstract：:Neurons in many species have large receptive fields that are selective for specific optic flow fields. Here, we studied the neural mechanisms underlying flow field selectivity in lobula plate tangential cells (LPTCs) of the blowfly. Among these cells, the H2 cell responds preferentially to visual stimuli approximating...

journal_title：Nature neuroscience

authors： Farrow K,Haag J,Borst A

更新日期：2006-10-01 00:00:00

abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...

journal_title：Nature neuroscience

authors： Kisler K,Nelson AR,Rege SV,Ramanathan A,Wang Y,Ahuja A,Lazic D,Tsai PS,Zhao Z,Zhou Y,Boas DA,Sakadžić S,Zlokovic BV

更新日期：2017-03-01 00:00:00

abstract：:Rhythmic movements, such as walking, chewing or scratching, are phylogenetically old motor behaviors found in many organisms, ranging from insects to primates. In contrast, discrete movements, such as reaching, grasping or kicking, are behaviors that have reached sophistication primarily in younger species, particular...

journal_title：Nature neuroscience

authors： Schaal S,Sternad D,Osu R,Kawato M

更新日期：2004-10-01 00:00:00

abstract：:The distinct electrical properties of axonal and dendritic membranes are largely a result of specific transport of vesicle-bound membrane proteins to each compartment. How this specificity arises is unclear because kinesin motors that transport vesicles cannot autonomously distinguish dendritically projecting microtub...

journal_title：Nature neuroscience

authors： Lewis TL Jr,Mao T,Svoboda K,Arnold DB

更新日期：2009-05-01 00:00:00

abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...

journal_title：Nature neuroscience

authors： McLean DL,Masino MA,Koh IY,Lindquist WB,Fetcho JR

更新日期：2008-12-01 00:00:00

abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...

journal_title：Nature neuroscience

authors： Mander BA,Marks SM,Vogel JW,Rao V,Lu B,Saletin JM,Ancoli-Israel S,Jagust WJ,Walker MP

更新日期：2015-07-01 00:00:00

abstract：:By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia (P = 3.3 × 10(-9)). We found only two heterozygous LoF variants in 45,376 exomes fro...

journal_title：Nature neuroscience

authors： Singh T,Kurki MI,Curtis D,Purcell SM,Crooks L,McRae J,Suvisaari J,Chheda H,Blackwood D,Breen G,Pietiläinen O,Gerety SS,Ayub M,Blyth M,Cole T,Collier D,Coomber EL,Craddock N,Daly MJ,Danesh J,DiForti M,Foster A,

更新日期：2016-04-01 00:00:00

abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...

journal_title：Nature neuroscience

authors： Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJ

更新日期：2004-06-01 00:00:00

abstract：:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any co...

journal_title：Nature neuroscience

authors： Grandjean D,Sander D,Pourtois G,Schwartz S,Seghier ML,Scherer KR,Vuilleumier P

更新日期：2005-02-01 00:00:00