Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.

abstract：:Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) an...

journal_title：Nature neuroscience

authors： Kisler K,Nelson AR,Rege SV,Ramanathan A,Wang Y,Ahuja A,Lazic D,Tsai PS,Zhao Z,Zhou Y,Boas DA,Sakadžić S,Zlokovic BV

更新日期：2017-03-01 00:00:00

abstract：:Increases in dopamine and glutamate transmission in the nucleus accumbens independently promote the reinstatement of cocaine seeking, an animal model of relapse. Here we have tested whether cocaine reinstatement in rats depends on interactions between accumbal dopamine and glutamate systems that are mediated by Ca(2+)...

journal_title：Nature neuroscience

authors： Anderson SM,Famous KR,Sadri-Vakili G,Kumaresan V,Schmidt HD,Bass CE,Terwilliger EF,Cha JH,Pierce RC

更新日期：2008-03-01 00:00:00

abstract：:A fundamental organizing principle of auditory brain circuits is tonotopy, the orderly representation of the sound frequency to which neurons are most sensitive. Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establ...

journal_title：Nature neuroscience

authors： Kandler K,Clause A,Noh J

更新日期：2009-06-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...

journal_title：Nature neuroscience

authors： Emes RD,Pocklington AJ,Anderson CN,Bayes A,Collins MO,Vickers CA,Croning MD,Malik BR,Choudhary JS,Armstrong JD,Grant SG

更新日期：2008-07-01 00:00:00

abstract：:Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...

journal_title：Nature neuroscience

authors： Lynch G

更新日期：2002-11-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...

journal_title：Nature neuroscience

authors： Kang Z,Wang C,Zepp J,Wu L,Sun K,Zhao J,Chandrasekharan U,DiCorleto PE,Trapp BD,Ransohoff RM,Li X

更新日期：2013-10-01 00:00:00

abstract：:Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin. ...

journal_title：Nature neuroscience

authors： Craig AM,Lichtman JW

更新日期：2001-03-01 00:00:00

abstract：:The morphological transition of growth cones to synaptic boutons characterizes synaptogenesis. Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family. Whereas earlier studies in Drosophila implicated Kinesin-1 in ...

journal_title：Nature neuroscience

authors： Pack-Chung E,Kurshan PT,Dickman DK,Schwarz TL

更新日期：2007-08-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...

journal_title：Nature neuroscience

authors： Kielar M,Tuy FP,Bizzotto S,Lebrand C,de Juan Romero C,Poirier K,Oegema R,Mancini GM,Bahi-Buisson N,Olaso R,Le Moing AG,Boutourlinsky K,Boucher D,Carpentier W,Berquin P,Deleuze JF,Belvindrah R,Borrell V,Welker E,Chel

更新日期：2014-07-01 00:00:00

abstract：:The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...

journal_title：Nature neuroscience

authors： Behra M,Cousin X,Bertrand C,Vonesch JL,Biellmann D,Chatonnet A,Strähle U

更新日期：2002-02-01 00:00:00

abstract：:We used high-level configural aftereffects induced by adaptation to realistic faces to investigate visual representations underlying complex pattern perception. We found that exposure to an individual face for a few seconds generated a significant and precise bias in the subsequent perception of face identity. In the ...

journal_title：Nature neuroscience

authors： Leopold DA,O'Toole AJ,Vetter T,Blanz V

更新日期：2001-01-01 00:00:00

abstract：:T cells clear virus from the CNS and dynamically regulate brain functions, including spatial learning, through cytokine signaling. Here we determined whether hippocampal T cells that persist after recovery from infection with West Nile virus (WNV) or Zika virus (ZIKV) impact hippocampal-dependent learning and memory. ...

journal_title：Nature neuroscience

authors： Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS

更新日期：2019-08-01 00:00:00

abstract：:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...

journal_title：Nature neuroscience

authors： Schiller D,Freeman JB,Mitchell JP,Uleman JS,Phelps EA

更新日期：2009-04-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature neuroscience

authors： Marschallinger J,Iram T,Zardeneta M,Lee SE,Lehallier B,Haney MS,Pluvinage JV,Mathur V,Hahn O,Morgens DW,Kim J,Tevini J,Felder TK,Wolinski H,Bertozzi CR,Bassik MC,Aigner L,Wyss-Coray T

更新日期：2020-02-01 00:00:00

abstract：:A localized transcriptome at the synapse facilitates synapse-, stimulus- and transcript-specific local protein synthesis in response to neuronal activity. While enzyme-mediated mRNA modifications are known to regulate cellular mRNA turnover, the role of these modifications in regulating synaptic RNA has not been studi...

journal_title：Nature neuroscience

authors： Merkurjev D,Hong WT,Iida K,Oomoto I,Goldie BJ,Yamaguti H,Ohara T,Kawaguchi SY,Hirano T,Martin KC,Pellegrini M,Wang DO

更新日期：2018-07-01 00:00:00

abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...

journal_title：Nature neuroscience

authors： Galli R,Borello U,Gritti A,Minasi MG,Bjornson C,Coletta M,Mora M,De Angelis MG,Fiocco R,Cossu G,Vescovi AL

更新日期：2000-10-01 00:00:00

abstract：:The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...

journal_title：Nature neuroscience

authors： O'Neill J,Senior TJ,Allen K,Huxter JR,Csicsvari J

更新日期：2008-02-01 00:00:00

abstract：:Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

journal_title：Nature neuroscience

authors： Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

更新日期：2017-01-01 00:00:00

abstract：:We combined psychophysical and transcranial magnetic stimulation studies to investigate the dynamics of action anticipation and its underlying neural correlates in professional basketball players. Athletes predicted the success of free shots at a basket earlier and more accurately than did individuals with comparable ...

journal_title：Nature neuroscience

authors： Aglioti SM,Cesari P,Romani M,Urgesi C

更新日期：2008-09-01 00:00:00

abstract：:Neurons in thalamorecipient layers of sensory cortices integrate thalamocortical and intracortical inputs. Although we know that their functional properties can arise from the convergence of thalamic inputs, intracortical circuits could also be involved in thalamocortical transformations of sensory information. We sil...

journal_title：Nature neuroscience

authors： Li YT,Ibrahim LA,Liu BH,Zhang LI,Tao HW

更新日期：2013-09-01 00:00:00

abstract：:It is unclear how knowledge of one's actions and one's body contribute to the understanding of others' actions. Here we show that two subjects lacking cutaneous touch and sense of movement and position show a selective deficit in interpreting another person's anticipation of weight when seeing him lifting boxes. We su...

journal_title：Nature neuroscience

authors： Bosbach S,Cole J,Prinz W,Knoblich G

更新日期：2005-10-01 00:00:00

abstract：:Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...

journal_title：Nature neuroscience

authors： Womelsdorf T,Valiante TA,Sahin NT,Miller KJ,Tiesinga P

更新日期：2014-08-01 00:00:00

abstract：:TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cro...

journal_title：Nature neuroscience

authors： Tollervey JR,Curk T,Rogelj B,Briese M,Cereda M,Kayikci M,König J,Hortobágyi T,Nishimura AL,Zupunski V,Patani R,Chandran S,Rot G,Zupan B,Shaw CE,Ule J

更新日期：2011-04-01 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...

journal_title：Nature neuroscience

authors： Lee HK,Min SS,Gallagher M,Kirkwood A

更新日期：2005-12-01 00:00:00

abstract：:Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...

journal_title：Nature neuroscience

authors： Hauner KK,Howard JD,Zelano C,Gottfried JA

更新日期：2013-11-01 00:00:00

abstract：:Deciphering the interneuronal circuitry is central to understanding brain functions, yet it remains a challenging task in neurobiology. Using simultaneous quadruple-octuple in vitro and dual in vivo whole-cell recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) intern...

journal_title：Nature neuroscience

authors： Jiang X,Wang G,Lee AJ,Stornetta RL,Zhu JJ

更新日期：2013-02-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00