Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.

abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...

journal_title：Nature neuroscience

authors： Krashes MJ,Lowell BB,Garfield AS

更新日期：2016-02-01 00:00:00

abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...

journal_title：Nature neuroscience

authors： Evers DM,Matta JA,Hoe HS,Zarkowsky D,Lee SH,Isaac JT,Pak DT

更新日期：2010-10-01 00:00:00

abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...

journal_title：Nature neuroscience

authors： Elsayed GF,Cunningham JP

更新日期：2017-09-01 00:00:00

abstract：:Although inherently linked, body form and body action may be represented in separate neural substrates. Using repetitive transcranial magnetic stimulation in healthy individuals, we show that interference with the extrastriate body area impairs the discrimination of bodily forms, and interference with the ventral prem...

journal_title：Nature neuroscience

authors： Urgesi C,Candidi M,Ionta S,Aglioti SM

更新日期：2007-01-01 00:00:00

abstract：:Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate componen...

journal_title：Nature neuroscience

authors： van Praag H,Kempermann G,Gage FH

更新日期：1999-03-01 00:00:00

abstract：:Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circ...

journal_title：Nature neuroscience

authors： Williams KW,Elmquist JK

更新日期：2012-10-01 00:00:00

abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...

journal_title：Nature neuroscience

authors： Shimojo S,Simion C,Shimojo E,Scheier C

更新日期：2003-12-01 00:00:00

abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...

journal_title：Nature neuroscience

authors： von Gall C,Garabette ML,Kell CA,Frenzel S,Dehghani F,Schumm-Draeger PM,Weaver DR,Korf HW,Hastings MH,Stehle JH

更新日期：2002-03-01 00:00:00

abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...

journal_title：Nature neuroscience

authors： Kondo S,Ohki K

更新日期：2016-02-01 00:00:00

abstract：:Adult expertise in face processing is mediated largely by neural networks in the right hemisphere. Here we evaluate the contribution of early visual input in establishing this neural substrate. We compared visually normal individuals to patients for whom visual input had been restricted mainly to one hemisphere during...

journal_title：Nature neuroscience

authors： Le Grand R,Mondloch CJ,Maurer D,Brent HP

更新日期：2003-10-01 00:00:00

abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...

journal_title：Nature neuroscience

authors： Wolpert DM,Ghahramani Z

更新日期：2000-11-01 00:00:00

abstract：:In this Perspective, we expand the notion of temporal regulation of RNA in the brain and propose that the qualitative nature of RNA and its metabolism, together with RNA abundance, are essential for the molecular mechanisms underlying experience-dependent plasticity. We discuss emerging concepts in the newly burgeonin...

journal_title：Nature neuroscience

authors： Nainar S,Marshall PR,Tyler CR,Spitale RC,Bredy TW

更新日期：2016-09-27 00:00:00

abstract：:Synaptic vesicles release neurotransmitter both actively (on stimulation) and spontaneously (at rest). It has been assumed that identical vesicles use both modes of release; however, recent evidence has challenged this view. Using several assays (FM dye imaging, pHluorin imaging and antibody-labeling of synaptotagmin)...

journal_title：Nature neuroscience

authors： Wilhelm BG,Groemer TW,Rizzoli SO

更新日期：2010-12-01 00:00:00

abstract：:Previous gene knockout studies have shown that the orphan glutamate receptor delta2 (GluRdelta2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells during development. However, the precise function of GluRdelta2 and whether it is functional in the mature cerebellum remain unclear. To a...

journal_title：Nature neuroscience

authors： Hirai H,Launey T,Mikawa S,Torashima T,Yanagihara D,Kasaura T,Miyamoto A,Yuzaki M

更新日期：2003-08-01 00:00:00

abstract：:Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...

journal_title：Nature neuroscience

authors： Szapiro G,Barbour B

更新日期：2007-06-01 00:00:00

abstract：:The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...

journal_title：Nature neuroscience

authors： Deneris ES,Hobert O

更新日期：2014-07-01 00:00:00

abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...

journal_title：Nature neuroscience

authors： Esteve P,Rueda-Carrasco J,Inés Mateo M,Martin-Bermejo MJ,Draffin J,Pereyra G,Sandonís Á,Crespo I,Moreno I,Aso E,Garcia-Esparcia P,Gomez-Tortosa E,Rábano A,Fortea J,Alcolea D,Lleo A,Heneka MT,Valpuesta JM,Esteban JA,

更新日期：2019-08-01 00:00:00

abstract：:Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...

journal_title：Nature neuroscience

authors： Yu FH,Mantegazza M,Westenbroek RE,Robbins CA,Kalume F,Burton KA,Spain WJ,McKnight GS,Scheuer T,Catterall WA

更新日期：2006-09-01 00:00:00

abstract：:Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological ...

journal_title：Nature neuroscience

authors： Storkebaum E,Quaegebeur A,Vikkula M,Carmeliet P

更新日期：2011-10-26 00:00:00

abstract：:Persistent neural activity in the absence of a stimulus has been identified as a neural correlate of working memory, but how such activity is maintained by neocortical circuits remains unknown. We used a computational approach to show that the inhibitory and excitatory microcircuitry of neocortical memory-storing regi...

journal_title：Nature neuroscience

authors： Lim S,Goldman MS

更新日期：2013-09-01 00:00:00

abstract：:The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...

journal_title：Nature neuroscience

authors： Ramnani N,Miall RC

更新日期：2004-01-01 00:00:00

abstract：:Short-term synaptic plasticity is a defining feature of neuronal activity, but the underlying molecular mechanisms are poorly understood. Depression of synaptic activity might be due to limited vesicle availability, whereas facilitation is thought to result from elevated calcium levels. However, it is unclear whether ...

journal_title：Nature neuroscience

authors： Sippy T,Cruz-Martín A,Jeromin A,Schweizer FE

更新日期：2003-10-01 00:00:00

abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...

journal_title：Nature neuroscience

authors： Iftinca M,Hamid J,Chen L,Varela D,Tadayonnejad R,Altier C,Turner RW,Zamponi GW

更新日期：2007-07-01 00:00:00

abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...

journal_title：Nature neuroscience

authors： Wu HG,Miyamoto YR,Gonzalez Castro LN,Ölveczky BP,Smith MA

更新日期：2014-02-01 00:00:00

abstract：:Declarative memory, the conscious recollection of past experiences, is known to involve the hippocampus. Now a study of amnesic patients shows that hippocampus-dependent learning can occur in the absence of conscious awareness. ...

journal_title：Nature neuroscience

authors： Eichenbaum H

更新日期：1999-09-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...

journal_title：Nature neuroscience

authors： Viard P,Butcher AJ,Halet G,Davies A,Nürnberg B,Heblich F,Dolphin AC

更新日期：2004-09-01 00:00:00

abstract：:In vivo model systems are a critical tool for gaining insight into the pathology underlying psychiatric disorders. Although modern functional imaging tools allow study of brain correlates of behavior in clinical groups and genome-wide association studies are beginning to uncover the complex genetic architecture of psy...

journal_title：Nature neuroscience

authors： Averbeck BB,Chafee MV

更新日期：2016-11-01 00:00:00

abstract：:Ongoing sensory input is critical for shaping internal representations of the external world. Conversely, a lack of sensory input can profoundly perturb the formation of these representations. The olfactory system is particularly vulnerable to sensory deprivation, owing to the widespread prevalence of allergic, viral ...

journal_title：Nature neuroscience

authors： Wu KN,Tan BK,Howard JD,Conley DB,Gottfried JA

更新日期：2012-09-01 00:00:00

abstract：:Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...

journal_title：Nature neuroscience

authors： Emes RD,Pocklington AJ,Anderson CN,Bayes A,Collins MO,Vickers CA,Croning MD,Malik BR,Choudhary JS,Armstrong JD,Grant SG

更新日期：2008-07-01 00:00:00

abstract：:Lis1 gene defects impair neuronal migration, causing the severe human brain malformation lissencephaly. Although much is known about its interactions with microtubules, microtubule-binding proteins such as CLIP-170, and with the dynein motor complex, the response of Lis1 to neuronal motility signals has not been eluci...

journal_title：Nature neuroscience

authors： Kholmanskikh SS,Koeller HB,Wynshaw-Boris A,Gomez T,Letourneau PC,Ross ME

更新日期：2006-01-01 00:00:00