Abstract：
:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Marek R,Jin J,Goode TD,Giustino TF,Wang Q,Acca GM,Holehonnur R,Ploski JE,Fitzgerald PJ,Lynagh T,Lynch JW,Maren S,Sah Pdoi
10.1038/s41593-018-0183-4subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1291issue
9eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0183-4journal_volume
21pub_type
已发布勘误abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1289
更新日期：2004-08-01 00:00:00
abstract：:UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0328-5
更新日期：2019-03-01 00:00:00
abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4186
更新日期：2016-01-01 00:00:00
abstract：:The classic 'size principle' of motor control describes how increasingly forceful movements arise by the recruitment of motoneurons of progressively larger size and force output into the active pool. We explored the activity of pools of spinal interneurons in larval zebrafish and found that increases in swimming speed...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2225
更新日期：2008-12-01 00:00:00
abstract：:It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2223
更新日期：2009-01-01 00:00:00
abstract：:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2751
更新日期：2011-03-01 00:00:00
abstract：:Sensory pathways are typically studied by starting at receptor neurons and following postsynaptic neurons into the brain. However, this leads to a bias in analyses of activity toward the earliest layers of processing. Here, we present new methods for volumetric neural imaging with precise across-brain registration to ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-00743-y
更新日期：2021-01-01 00:00:00
abstract：:Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses,...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4553
更新日期：2017-06-01 00:00:00
abstract：:Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn0901-894
更新日期：2001-09-01 00:00:00
abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2233
更新日期：2009-01-01 00:00:00
abstract：:The projections and odor responses of mammalian olfactory receptor neurons, as well as the physiology of the bulb's principal neurons-the mitral cells (MCs)-are known from studies in slices and anesthetized animals. In behaving rats trained to discriminate between two odors associated with different reinforcers, we ex...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/14801
更新日期：1999-11-01 00:00:00
abstract：:Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn835
更新日期：2002-05-01 00:00:00
abstract：:Using magnetoencephalography (MEG), we compared the processing of sinusoidal tones in the auditory cortex of 12 non-musicians, 12 professional musicians and 13 amateur musicians. We found neurophysiological and anatomical differences between groups. In professional musicians as compared to non-musicians, the activity ...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn871
更新日期：2002-07-01 00:00:00
abstract：:Polyamines are endogenous molecules involved in cell damage following neurological insults, although it is unclear whether polyamines reduce or exacerbate this damage. We used a developmental seizure model in which we exposed Xenopus laevis tadpoles to pentylenetetrazole (PTZ), a known convulsant. We found that, after...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2777
更新日期：2011-04-01 00:00:00
abstract：:Electrical stimulation of visual cortex can produce a visual percept (phosphene). We electrically stimulated visual cortex in humans implanted with subdural electrodes while recording from other brain sites. Phosphene perception occurred only if stimulation evoked high-frequency gamma oscillations in the temporopariet...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3131
更新日期：2012-06-03 00:00:00
abstract：:Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3973
更新日期：2015-04-01 00:00:00
abstract：:Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expression changes withi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0621-y
更新日期：2020-06-01 00:00:00
abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3207
更新日期：2012-10-01 00:00:00
abstract：:It is widely held that color and motion are processed by separate parallel pathways in the visual system, but this view is difficult to reconcile with the fact that motion can be detected in equiluminant stimuli that are defined by color alone. To examine the relationship between color and motion, we tested three pati...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/688
更新日期：1998-07-01 00:00:00
abstract：:A-kinase anchoring proteins (AKAPs) constitute a family of scaffolding proteins that bind the regulatory subunits of protein kinase A (PKA). AKAP binding to PKA regulates the phosphorylation of various proteins, some of which have been implicated in synaptic plasticity and memory consolidation. Here we show that the r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn901
更新日期：2002-09-01 00:00:00
abstract：:Individual behavioral performance during learning is known to be affected by modulatory factors, such as stress and motivation, and by genetic predispositions that influence sensitivity to these factors. Despite numerous studies, no integrative framework is available that could predict how a given animal would perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2374
更新日期：2009-09-01 00:00:00
abstract：:Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn935
更新日期：2002-11-01 00:00:00
abstract：:Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally i...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2239
更新日期：2009-01-01 00:00:00
abstract：:Many cells in retinotopic brain areas increase their activity when saccades (rapid eye movements) are about to bring stimuli into their receptive fields. Although previous work has attempted to look at the functional correlates of such predictive remapping, no study has explicitly tested for better attentional perform...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2711
更新日期：2011-02-01 00:00:00
abstract：:It has been debated whether orientation selectivity in mouse primary visual cortex (V1) is derived from tuned lateral geniculate nucleus (LGN) inputs or computed from untuned LGN inputs. However, few studies have measured orientation tuning of LGN axons projecting to V1. We measured the response properties of mouse LG...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4215
更新日期：2016-02-01 00:00:00
abstract：:Fever is a result of the action of prostaglandin E2 (PGE2) on the brain and appears to require EP3 prostaglandin receptors (EP3Rs), but the specific neurons on which PGE2 acts to produce fever have not been definitively established. Here we report that selective genetic deletion of the EP3Rs in the median preoptic nuc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1949
更新日期：2007-09-01 00:00:00
abstract：:A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and brain damage. Despite the involvement of distinct proteins in different NDs, the process of protein misfolding and aggregation is remarka...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/s41593-018-0235-9
更新日期：2018-10-01 00:00:00
abstract：:Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0370-y
更新日期：2019-05-01 00:00:00
abstract：:Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn884
更新日期：2002-08-01 00:00:00
abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0677-8
更新日期：2020-10-01 00:00:00
