Abstract:
:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Murray AJ,Sauer JF,Riedel G,McClure C,Ansel L,Cheyne L,Bartos M,Wisden W,Wulff Pdoi
10.1038/nn.2751subject
Has Abstractpub_date
2011-03-01 00:00:00pages
297-9issue
3eissn
1097-6256issn
1546-1726pii
nn.2751journal_volume
14pub_type
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