Paternal recognition of adult offspring mediated by newly generated CNS neurons.

Abstract:

:In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition behavior and associated brain plasticity has been well characterized, but paternal recognition behavior and brain plasticity is poorly understood. We found that paternal-adult offspring recognition behavior in mice was dependent on postnatal offspring interaction and was associated with increased neurogenesis in the paternal olfactory bulb and hippocampus. Newly generated paternal olfactory interneurons were preferentially activated by adult offspring odors. Disrupting prolactin signaling abolished increased paternal neurogenesis and adult offspring recognition. Rescuing this neurogenesis restored recognition behavior. Thus, neurogenesis in the paternal brain may be involved in offspring recognition.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Mak GK,Weiss S

doi

10.1038/nn.2550

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

753-8

issue

6

eissn

1097-6256

issn

1546-1726

pii

nn.2550

journal_volume

13

pub_type

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