Abstract:
:In mammals, olfaction is often used to distinguish individuals on the basis of their unique odor types (genetically programmed body odors). Parental-offspring recognition behavior is mediated, in part, by learning and processing of different odor types and is crucial for reproductive success. Maternal recognition behavior and associated brain plasticity has been well characterized, but paternal recognition behavior and brain plasticity is poorly understood. We found that paternal-adult offspring recognition behavior in mice was dependent on postnatal offspring interaction and was associated with increased neurogenesis in the paternal olfactory bulb and hippocampus. Newly generated paternal olfactory interneurons were preferentially activated by adult offspring odors. Disrupting prolactin signaling abolished increased paternal neurogenesis and adult offspring recognition. Rescuing this neurogenesis restored recognition behavior. Thus, neurogenesis in the paternal brain may be involved in offspring recognition.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Mak GK,Weiss Sdoi
10.1038/nn.2550subject
Has Abstractpub_date
2010-06-01 00:00:00pages
753-8issue
6eissn
1097-6256issn
1546-1726pii
nn.2550journal_volume
13pub_type
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