Early and rapid perceptual learning.

abstract：:Shared neural variability is ubiquitous in cortical populations. While this variability is presumed to arise from overlapping synaptic input, its precise relationship to local circuit architecture remains unclear. We combine computational models and in vivo recordings to study the relationship between the spatial stru...

journal_title：Nature neuroscience

authors： Rosenbaum R,Smith MA,Kohn A,Rubin JE,Doiron B

更新日期：2017-01-01 00:00:00

abstract：:Here we used magnetoencephalography (MEG) to investigate stages of processing in face perception in humans. We found a face-selective MEG response occurring only 100 ms after stimulus onset (the 'M100'), 70 ms earlier than previously reported. Further, the amplitude of this M100 response was correlated with successful...

journal_title：Nature neuroscience

authors： Liu J,Harris A,Kanwisher N

更新日期：2002-09-01 00:00:00

abstract：:Spillover of glutamate under physiological conditions has only been established as an adjunct to conventional synaptic transmission. Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex. We show that, instead of acting via conventional sy...

journal_title：Nature neuroscience

authors： Szapiro G,Barbour B

更新日期：2007-06-01 00:00:00

abstract：:The neural basis of aggression is poorly understood. A study in this issue used genetic scalpels to dissect the circuitry of the fly brain and identified a small cluster of octopaminergic neurons that can make a fly fighting mad. ...

journal_title：Nature neuroscience

authors： Potter CJ,Luo L

更新日期：2008-09-01 00:00:00

abstract：:Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...

journal_title：Nature neuroscience

authors： Huang H,Kong D,Byun KH,Ye C,Koda S,Lee DH,Oh BC,Lee SW,Lee B,Zabolotny JM,Kim MS,Bjørbæk C,Lowell BB,Kim YB

更新日期：2012-10-01 00:00:00

abstract：:Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...

journal_title：Nature neuroscience

authors： Schwartz GW,Okawa H,Dunn FA,Morgan JL,Kerschensteiner D,Wong RO,Rieke F

更新日期：2012-11-01 00:00:00

abstract：:The molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx. Here, we demonstrate a previously unknown interaction between two components of the presynaptic active zone, RIM1 and voltage-dependent Ca2+ channels (VDCCs), th...

journal_title：Nature neuroscience

authors： Kiyonaka S,Wakamori M,Miki T,Uriu Y,Nonaka M,Bito H,Beedle AM,Mori E,Hara Y,De Waard M,Kanagawa M,Itakura M,Takahashi M,Campbell KP,Mori Y

更新日期：2007-06-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00

abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...

journal_title：Nature neuroscience

authors： Trimarco A,Forese MG,Alfieri V,Lucente A,Brambilla P,Dina G,Pieragostino D,Sacchetta P,Urade Y,Boizet-Bonhoure B,Martinelli Boneschi F,Quattrini A,Taveggia C

更新日期：2014-12-01 00:00:00

abstract：:Successfully navigating in physical or semantic space requires a neural representation of allocentric (map-based) vectors to boundaries, objects and goals. Cognitive processes such as path-planning and imagination entail the recall of vector representations, but evidence of neuron-level memory for allocentric vectors ...

journal_title：Nature neuroscience

authors： Poulter S,Lee SA,Dachtler J,Wills TJ,Lever C

更新日期：2020-12-21 00:00:00

abstract：:The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses...

journal_title：Nature neuroscience

authors： Kay L,Humphreys L,Eickholt BJ,Burrone J

更新日期：2011-06-01 00:00:00

abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...

journal_title：Nature neuroscience

authors： Magee JC,Cook EP

更新日期：2000-09-01 00:00:00

abstract：:The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. T...

journal_title：Nature neuroscience

authors： Rossi MA,Li HE,Lu D,Kim IH,Bartholomew RA,Gaidis E,Barter JW,Kim N,Cai MT,Soderling SH,Yin HH

更新日期：2016-05-01 00:00:00

abstract：:Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...

journal_title：Nature neuroscience

authors： García-Alías G,Barkhuysen S,Buckle M,Fawcett JW

更新日期：2009-09-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...

journal_title：Nature neuroscience

authors： Kang Z,Wang C,Zepp J,Wu L,Sun K,Zhao J,Chandrasekharan U,DiCorleto PE,Trapp BD,Ransohoff RM,Li X

更新日期：2013-10-01 00:00:00

abstract：:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...

journal_title：Nature neuroscience

authors： Yudowski GA,Puthenveedu MA,von Zastrow M

更新日期：2006-05-01 00:00:00

abstract：:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...

journal_title：Nature neuroscience

authors： Li Y,Xu J,Liu Y,Zhu J,Liu N,Zeng W,Huang N,Rasch MJ,Jiang H,Gu X,Li X,Luo M,Li C,Teng J,Chen J,Zeng S,Lin L,Zhang X

更新日期：2017-04-01 00:00:00

abstract：:Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...

journal_title：Nature neuroscience

authors： Wisotsky Z,Medina A,Freeman E,Dahanukar A

更新日期：2011-11-06 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...

journal_title：Nature neuroscience

authors： Pecho-Vrieseling E,Rieker C,Fuchs S,Bleckmann D,Esposito MS,Botta P,Goldstein C,Bernhard M,Galimberti I,Müller M,Lüthi A,Arber S,Bouwmeester T,van der Putten H,Di Giorgio FP

更新日期：2014-08-01 00:00:00

abstract：:Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention score...

journal_title：Nature neuroscience

authors： Lynch G

更新日期：2002-11-01 00:00:00

abstract：:An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indire...

journal_title：Nature neuroscience

authors： Aston-Jones G,Chen S,Zhu Y,Oshinsky ML

更新日期：2001-07-01 00:00:00

abstract：:Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-associated release of noradrenaline enhances the capacity of central synapses to show plasticity (metaplasticity). We found noradrenaline-dependent metaplasticity at GABA synapses in the paraventricular nucleus of the hypot...

journal_title：Nature neuroscience

authors： Inoue W,Baimoukhametova DV,Füzesi T,Wamsteeker Cusulin JI,Koblinger K,Whelan PJ,Pittman QJ,Bains JS

更新日期：2013-05-01 00:00:00

abstract：:The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...

journal_title：Nature neuroscience

authors： Putz U,Harwell C,Nedivi E

更新日期：2005-03-01 00:00:00

abstract：:The mammalian visual system contains an extensive web of feedback connections projecting from higher cortical areas to lower areas, including primary visual cortex. Although multiple theories have been proposed, the role of these connections in perceptual processing is not understood. We found that the pattern of func...

journal_title：Nature neuroscience

authors： Williams MA,Baker CI,Op de Beeck HP,Shim WM,Dang S,Triantafyllou C,Kanwisher N

更新日期：2008-12-01 00:00:00

abstract：:Synaptic strength can be altered by a variety of pre- or postsynaptic modifications. Here we test the hypothesis that long-term depression (LTD) involves a decrease in the number of glutamate receptors that are clustered at individual synapses in primary cultures of hippocampal neurons. Similar to a prominent form of ...

journal_title：Nature neuroscience

authors： Carroll RC,Lissin DV,von Zastrow M,Nicoll RA,Malenka RC

更新日期：1999-05-01 00:00:00

abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...

journal_title：Nature neuroscience

authors： Navratilova E,Porreca F

更新日期：2014-10-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00

abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Marek R,Jin J,Goode TD,Giustino TF,Wang Q,Acca GM,Holehonnur R,Ploski JE,Fitzgerald PJ,Lynagh T,Lynch JW,Maren S,Sah P

更新日期：2018-09-01 00:00:00

abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...

journal_title：Nature neuroscience

authors： Ito I,Ong RC,Raman B,Stopfer M

更新日期：2008-10-01 00:00:00