Abstract:
:The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kay L,Humphreys L,Eickholt BJ,Burrone Jdoi
10.1038/nn.2826subject
Has Abstractpub_date
2011-06-01 00:00:00pages
688-90issue
6eissn
1097-6256issn
1546-1726pii
nn.2826journal_volume
14pub_type
杂志文章abstract::Transmitter release is triggered by highly localized, transient increases in the presynaptic Ca(2+) concentration ([Ca(2+)]). Rapidly decaying [Ca(2+)] elevations were generated using Ca(2+) uncaging techniques, and [Ca(2+)] was measured with a low-affinity Ca(2+) indicator in a giant presynaptic terminal, the calyx o...
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doi:10.1038/nn1126
更新日期:2003-10-01 00:00:00
abstract::Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...
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更新日期:2016-11-01 00:00:00
abstract::The dorsal root ganglia (DRG) contain a variety of mechanoreceptors, but no molecular markers uniquely identify specific mechanoreceptor subtypes. We have used DNA microarrays and subtracted cDNA libraries to isolate genes that are specifically expressed by one type of mouse mechanoreceptor. The T-type calcium channel...
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abstract::EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1655
更新日期:2006-03-01 00:00:00
abstract::Nature Neuroscience presents a special issue of recent advances on shared mechanisms underlying neurodegenerative disease. ...
journal_title:Nature neuroscience
pub_type: 社论
doi:10.1038/s41593-018-0250-x
更新日期:2018-10-01 00:00:00
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journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2461
更新日期:2010-01-01 00:00:00
abstract::Understanding a sensory system implies the ability to predict responses to a variety of inputs from a common model. In the retina, this includes predicting how the integration of signals across visual space shapes the outputs of retinal ganglion cells. Existing models of this process generalize poorly to predict respo...
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更新日期:2002-11-01 00:00:00
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更新日期:2000-08-01 00:00:00
abstract::The healthy human brain is a mosaic of varied genomes. Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosaicism by inserting L1 sequences into new locations of somatic cell genomes. Using a machine learning-based, single-cell sequencing approach, we discovered that somatic L1-associat...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4388
更新日期:2016-12-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
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pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::Very little is known about how stimuli that are typically not rich in sugars, such as beer, trigger attractive gustatory responses in Drosophila. We identified a member of the gustatory receptor family, Gr64e, as a receptor that is required for feeding preference for beer and other sources that have fermenting yeast. ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2944
更新日期:2011-11-06 00:00:00
abstract::An object viewed from different angles can be recognized and distinguished from similar distractors after the viewer has had experience watching it rotate. It has been assumed that as an observer watches the rotation, separate representations of individual views become associated with one another. However, we show her...
journal_title:Nature neuroscience
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doi:10.1038/nn1600
更新日期:2005-12-01 00:00:00
abstract::Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...
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更新日期:2011-11-20 00:00:00
abstract::Illusions that produce perceptual suppression despite constant retinal input are used to manipulate visual consciousness. Here we report on a powerful variant of existing techniques, continuous flash suppression. Distinct images flashed successively at approximately 10 Hz into one eye reliably suppress an image presen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1500
更新日期:2005-08-01 00:00:00
abstract::The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...
journal_title:Nature neuroscience
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/nn.2665
更新日期:2010-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/nn.2558
更新日期:2010-06-01 00:00:00
abstract::Voltage-gated sodium channels (Na(V)) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in Na(V)1.1 channels cause severe myoclonic epilepsy in infancy (SMEI). Homozygous null Scn1a-/- mice developed ataxia and died on postnatal day (P) 15 but could be sustained to P17.5 with ma...
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pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
abstract::We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...
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pub_type: 杂志文章,评审
doi:10.1038/nn1770
更新日期:2006-10-01 00:00:00
abstract::The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...
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更新日期:2016-09-01 00:00:00
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journal_title:Nature neuroscience
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更新日期:2020-10-01 00:00:00
abstract::Oxytocin is an essential hormone for mammalian labor and lactation. Here, we show a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood. In oxytocin-perfused hippocampal slices, one-train tetanus stimulation induced long-lasting, long-term potentiation (L-LTP) and phosphorylat...
journal_title:Nature neuroscience
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doi:10.1038/nn1023
更新日期:2003-04-01 00:00:00