Multimodal population brain imaging in the UK Biobank prospective epidemiological study.

Abstract:

:Medical imaging has enormous potential for early disease prediction, but is impeded by the difficulty and expense of acquiring data sets before symptom onset. UK Biobank aims to address this problem directly by acquiring high-quality, consistently acquired imaging data from 100,000 predominantly healthy participants, with health outcomes being tracked over the coming decades. The brain imaging includes structural, diffusion and functional modalities. Along with body and cardiac imaging, genetics, lifestyle measures, biological phenotyping and health records, this imaging is expected to enable discovery of imaging markers of a broad range of diseases at their earliest stages, as well as provide unique insight into disease mechanisms. We describe UK Biobank brain imaging and present results derived from the first 5,000 participants' data release. Although this covers just 5% of the ultimate cohort, it has already yielded a rich range of associations between brain imaging and other measures collected by UK Biobank.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Miller KL,Alfaro-Almagro F,Bangerter NK,Thomas DL,Yacoub E,Xu J,Bartsch AJ,Jbabdi S,Sotiropoulos SN,Andersson JL,Griffanti L,Douaud G,Okell TW,Weale P,Dragonu I,Garratt S,Hudson S,Collins R,Jenkinson M,Matthews PM,

doi

10.1038/nn.4393

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1523-1536

issue

11

eissn

1097-6256

issn

1546-1726

pii

nn.4393

journal_volume

19

pub_type

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