Abstract：
:Adult neurogenesis occurs in the hippocampus and the olfactory bulb of the mammalian CNS. Recent studies have demonstrated that newborn granule cells of the adult hippocampus are postsynaptic targets of excitatory and inhibitory neurons, but evidence of synapse formation by the axons of these cells is still lacking. By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, we found output synapses that were formed by labeled terminals on appropriate target cells in the CA3 area and the hilus. Furthermore, retroviral expression of channelrhodopsin-2 allowed us to light-stimulate newborn granule cells and identify postsynaptic target neurons by whole-cell recordings in acute slices. Our structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Toni N,Laplagne DA,Zhao C,Lombardi G,Ribak CE,Gage FH,Schinder AFdoi
10.1038/nn.2156subject
Has Abstractpub_date
2008-08-01 00:00:00pages
901-7issue
8eissn
1097-6256issn
1546-1726pii
nn.2156journal_volume
11pub_type
杂志文章abstract：:Dendritic spines undergo actin-based growth and shrinkage during synaptic plasticity, in which the actin depolymerizing factor (ADF)/cofilin family of actin-associated proteins are important. Elevated ADF/cofilin activities often lead to reduced spine size and immature spine morphology but can also enhance synaptic po...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2634
更新日期：2010-10-01 00:00:00
abstract：:The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation. Ove...
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pub_type： 杂志文章,评审
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abstract：:Social behaviors recruit multiple cognitive operations that require interactions between cortical and subcortical brain regions. Interareal synchrony may facilitate such interactions between cortical and subcortical neural populations. However, it remains unknown how neurons from different nodes in the social brain ne...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-020-0593-y
更新日期：2020-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2582
更新日期：2010-08-01 00:00:00
abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0315-x
更新日期：2019-03-01 00:00:00
abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title：Nature neuroscience
pub_type： 杂志文章
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journal_title：Nature neuroscience
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更新日期：2017-01-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2006-05-01 00:00:00
abstract：:The orbitofrontal cortex plays a central role in good-based economic decisions. When subjects make choices, neurons in this region represent the identities and values of offered and chosen goods. Notably, choices in different behavioral contexts may involve a potentially infinite variety of goods. Thus a fundamental q...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4300
更新日期：2016-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2182
更新日期：2008-09-01 00:00:00
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.4494
更新日期：2017-03-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1734
更新日期：2006-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/84023
更新日期：2001-02-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn935
更新日期：2002-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn.3419
更新日期：2013-07-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/81823
更新日期：2000-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/nn769
更新日期：2001-12-01 00:00:00
abstract：:When sleep followed implicit training on a motor sequence, children showed greater gains in explicit sequence knowledge after sleep than adults. This greater explicit knowledge in children was linked to their higher sleep slow-wave activity and to stronger hippocampal activation at explicit knowledge retrieval. Our da...
journal_title：Nature neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1038/nn.3343
更新日期：2013-04-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
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更新日期：2000-01-01 00:00:00
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更新日期：2012-03-11 00:00:00
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doi：10.1038/nn1655
更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-08-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2011-11-20 00:00:00
abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
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更新日期：2019-12-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.2947
更新日期：2011-10-26 00:00:00
abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1251
更新日期：2004-06-01 00:00:00
abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4035
更新日期：2015-07-01 00:00:00
