Abstract：
:Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluorescence microscopy, resolved distinct vesicular fusion events mediating receptor insertion into the somatodendritic plasma membrane. A 'transient' insertion mode resulted in rapid lateral dispersion of receptors immediately after insertion. A 'persistent' insertion mode resulted in the retention of inserted receptors in surface-accessible domains, which were relatively immobile for a prolonged 'wait' period before dispersing laterally. Distinct insertion modes were oppositely regulated by receptor activation and by mechanisms differing in their dependence on the signaling effector cyclic AMP-dependent protein kinase. These results reveal a new mechanism for homeostatic regulation of postsynaptic signaling and a 'kiss-and-wait' mode of regulated membrane protein insertion in neurons.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Yudowski GA,Puthenveedu MA,von Zastrow Mdoi
10.1038/nn1679subject
Has Abstractpub_date
2006-05-01 00:00:00pages
622-7issue
5eissn
1097-6256issn
1546-1726pii
nn1679journal_volume
9pub_type
杂志文章abstract：:Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 receptors are mostly expressed in postsynaptic neurons, pharmacological and genetic approaches have been unable to definitively address the in viv...
journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2011-07-10 00:00:00
abstract：:Differentiation of CNS glia is regulated by Notch signaling through neuron-glia interaction. Here, we identified Delta/Notch-like EGF-related receptor (DNER), a neuron-specific transmembrane protein, as a previously unknown ligand of Notch during cellular morphogenesis of Bergmann glia in the mouse cerebellum. DNER bi...
journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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更新日期：2015-09-01 00:00:00
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更新日期：2018-05-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
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更新日期：2013-09-01 00:00:00
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更新日期：2003-04-01 00:00:00
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更新日期：2013-02-01 00:00:00
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更新日期：2010-08-01 00:00:00
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更新日期：2013-07-01 00:00:00
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更新日期：2007-02-01 00:00:00
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更新日期：2008-09-01 00:00:00
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更新日期：2016-02-01 00:00:00
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更新日期：2021-01-28 00:00:00
