Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections.

Abstract:

:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.

journal_name

Nat Neurosci

journal_title

Nature neuroscience

authors

Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PW

doi

10.1038/nn.4068

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

1230-2

issue

9

eissn

1097-6256

issn

1546-1726

pii

nn.4068

journal_volume

18

pub_type

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