Abstract:
:It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia, whereas D2-expressing neurons do so indirectly via pallidal neurons. Combining optogenetics and electrophysiology, we found that this architecture does not apply to mouse nucleus accumbens projections to the ventral pallidum. Thus, current thinking attributing D1 and D2 selectivity to accumbens projections akin to dorsal striatal pathways needs to be reconsidered.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Kupchik YM,Brown RM,Heinsbroek JA,Lobo MK,Schwartz DJ,Kalivas PWdoi
10.1038/nn.4068subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1230-2issue
9eissn
1097-6256issn
1546-1726pii
nn.4068journal_volume
18pub_type
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