Abstract:
:A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purkinje cells directly but also presynaptically inhibited GABAergic transmission from interneurons converging on the same Purkinje cells. Both homosynaptic and heterosynaptic actions of the CF transmitter (possibly glutamate) were mediated by activation of AMPA receptors. Dual AMPA receptor-mediated functions of excitation and disinhibition may ensure transmission of cerebellar CF signals controlling sensorimotor coordination.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Satake S,Saitow F,Yamada J,Konishi Sdoi
10.1038/75718subject
Has Abstractpub_date
2000-06-01 00:00:00pages
551-8issue
6eissn
1097-6256issn
1546-1726journal_volume
3pub_type
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