Abstract:
:The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to the development of the autonomic nervous system and rhombomere-related regulation of breathing, respectively. Mutations in these proteins can lead to abnormal breathing behavior as a result of an alteration in an unidentified neuronal system. We characterized a bilateral embryonic parafacial (e-pF) population of rhythmically bursting neurons at embryonic day (E) 14.5 in mice. These cells expressed Phox2b, were derived from Egr2-expressing precursors and their development was dependent on the integrity of the Egr2 gene. Silencing or eliminating the e-pF oscillator, but not the putative inspiratory oscillator (preBötzinger complex, preBötC), led to an abnormally slow rhythm, demonstrating that the e-pF controls the respiratory rhythm. The e-pF oscillator, the only one active at E14.5, entrained and then coupled with the preBötC, which emerged independently at E15.5. These data establish the dual organization of the respiratory rhythm generator at the time of its inception, when it begins to drive fetal breathing.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Thoby-Brisson M,Karlén M,Wu N,Charnay P,Champagnat J,Fortin Gdoi
10.1038/nn.2354subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1028-35issue
8eissn
1097-6256issn
1546-1726pii
nn.2354journal_volume
12pub_type
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