Abstract：
:Newborn microglia rapidly replenish the whole brain after selective elimination of most microglia (>99%) in adult mice. Previous studies reported that repopulated microglia were largely derived from microglial progenitor cells expressing nestin in the brain. However, the origin of these repopulated microglia has been hotly debated. In this study, we investigated the origin of repopulated microglia by a series of fate-mapping approaches. We first excluded the blood origin of repopulated microglia via parabiosis. With different transgenic mouse lines, we then demonstrated that all repopulated microglia were derived from the proliferation of the few surviving microglia (<1%). Despite a transient pattern of nestin expression in newly forming microglia, none of repopulated microglia were derived from nestin-positive non-microglial cells. In summary, we conclude that repopulated microglia are solely derived from residual microglia rather than de novo progenitors, suggesting the absence of microglial progenitor cells in the adult brain.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Huang Y,Xu Z,Xiong S,Sun F,Qin G,Hu G,Wang J,Zhao L,Liang YX,Wu T,Lu Z,Humayun MS,So KF,Pan Y,Li N,Yuan TF,Rao Y,Peng Bdoi
10.1038/s41593-018-0090-8subject
Has Abstractpub_date
2018-04-01 00:00:00pages
530-540issue
4eissn
1097-6256issn
1546-1726pii
10.1038/s41593-018-0090-8journal_volume
21pub_type
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