Abstract：
:Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intracellular cadherin binding protein δ-catenin is transiently palmitoylated by DHHC5 after enhanced synaptic activity and that palmitoylation increases δ-catenin-cadherin interactions at synapses. Both the palmitoylation of δ-catenin and its binding to cadherin are required for activity-induced stabilization of N-cadherin at synapses and the enlargement of postsynaptic spines, as well as the insertion of GluA1 and GluA2 subunits into the synaptic membrane and the concomitant increase in miniature excitatory postsynaptic current amplitude. Notably, context-dependent fear conditioning in mice resulted in increased δ-catenin palmitoylation, as well as increased δ-catenin-cadherin associations at hippocampal synapses. Together these findings suggest a role for palmitoylated δ-catenin in coordinating activity-dependent changes in synaptic adhesion molecules, synapse structure and receptor localization that are involved in memory formation.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Brigidi GS,Sun Y,Beccano-Kelly D,Pitman K,Mobasser M,Borgland SL,Milnerwood AJ,Bamji SXdoi
10.1038/nn.3657subject
Has Abstractpub_date
2014-04-01 00:00:00pages
522-32issue
4eissn
1097-6256issn
1546-1726pii
nn.3657journal_volume
17pub_type
杂志文章abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/71090
更新日期：2000-01-01 00:00:00
abstract：:The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are repr...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4374
更新日期：2016-10-01 00:00:00
abstract：:The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn831
更新日期：2002-04-01 00:00:00
abstract：:From insects to mammals, olfactory receptor neurons (ORNs) expressing a common olfactory receptor target their axons to specific glomeruli with high precision. Here we show in Drosophila that the POU transcription factor Acj6 controls the axon targeting specificity of a subset of ORN classes, as defined by the olfacto...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1284
更新日期：2004-08-01 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) has been shown to enhance native voltage-dependent calcium channel (Ca(v)) currents both in myocytes and in neurons; however, the mechanism(s) responsible for this regulation were not known. Here we show that PI3K promotes the translocation of GFP-tagged Ca(v) channels to the plasm...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1300
更新日期：2004-09-01 00:00:00
abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1593
更新日期：2006-01-01 00:00:00
abstract：:Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0341-3
更新日期：2019-04-01 00:00:00
abstract：:Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Chromatin immunoprecipitation f...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0490-4
更新日期：2019-11-01 00:00:00
abstract：:Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4289
更新日期：2016-06-01 00:00:00
abstract：:In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0114-4
更新日期：2018-07-01 00:00:00
abstract：:Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial re...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2751
更新日期：2011-03-01 00:00:00
abstract：:During development, the mammalian ventral telencephalon is comprised of three major proliferative zones: the medial (MGE), lateral (LGE) and caudal (CGE) ganglionic eminences. Through gene expression studies, in vitro migration assays, genetic mutant analysis and in vivo fate mapping in mice, we found that the CGE is ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn971
更新日期：2002-12-01 00:00:00
abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0405-4
更新日期：2019-06-01 00:00:00
abstract：:Neurotransmitter transporters can affect neuronal excitability indirectly via modulation of neurotransmitter concentrations or directly via transporter currents. A physiological or pathophysiological role for transporter currents has not been described. We found that GABA transporter 1 (GAT-1) cation currents directly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2940
更新日期：2011-10-30 00:00:00
abstract：:A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/75718
更新日期：2000-06-01 00:00:00
abstract：:Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3862
更新日期：2014-12-01 00:00:00
abstract：:Over the last 10 years, optogenetics has become widespread in neuroscience for the study of how specific cell types contribute to brain functions and brain disorder states. The full impact of optogenetics will emerge only when other toolsets mature, including neural connectivity and cell phenotyping tools and neural r...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章
doi：10.1038/nn.4094
更新日期：2015-09-01 00:00:00
abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1850
更新日期：2007-03-01 00:00:00
abstract：:To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changes in interspike membr...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/84023
更新日期：2001-02-01 00:00:00
abstract：:Cuing covert spatial attention can increase spatial resolution. Here we pinpointed the specific locus of this effect using texture segmentation. At the level of visual cortex, texture segmentation theoretically involves passage of visual input through two layers of spatial linear filters separated by a pointwise nonli...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/75804
更新日期：2000-06-01 00:00:00
abstract：:Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4494
更新日期：2017-03-01 00:00:00
abstract：:Neuroscience seeks to understand how neural circuits lead to behavior. However, the gap between circuits and behavior is too wide. An intermediate level is one of neural computations, which occur in individual neurons and populations of neurons. Some computations seem to be canonical: repeated and combined in differen...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3043
更新日期：2012-03-27 00:00:00
abstract：:Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal r...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2414
更新日期：2009-11-01 00:00:00
abstract：:How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2404
更新日期：2009-11-01 00:00:00
abstract：:By combining computational, morphological, and functional analyses, this study relates latent markers of associative threat learning to overt post-traumatic stress disorder (PTSD) symptoms in combat veterans. Using reversal learning, we found that symptomatic veterans showed greater physiological adjustment to cues th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0315-x
更新日期：2019-03-01 00:00:00
abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4475
更新日期：2017-02-01 00:00:00
abstract：:Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3051
更新日期：2012-02-26 00:00:00
abstract：:Autism spectrum disorder (ASD) is genetically heterogeneous with convergent symptomatology, suggesting common dysregulated pathways. In this study, we analyzed brain transcriptional changes in five mouse models of Pitt-Hopkins syndrome (PTHS), a syndromic form of ASD caused by mutations in the TCF4 gene, but not the T...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0578-x
更新日期：2020-03-01 00:00:00
abstract：:Temporal and quantitative relations between excitatory and inhibitory inputs in the cortex are central to its activity, yet they remain poorly understood. In particular, a controversy exists regarding the extent of correlation between cortical excitation and inhibition. Using simultaneous intracellular recordings in p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2105
更新日期：2008-05-01 00:00:00
abstract：:Breathing is a bilaterally synchronous behavior that relies on a respiratory rhythm generator located in the brainstem. An essential component of this generator is the preBötzinger complex (preBötC), which paces inspirations. Little is known about the developmental origin of the interneuronal populations forming the p...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2622
更新日期：2010-09-01 00:00:00
