The locus of attentional effects in texture segmentation.

abstract：:The balance between proliferation and apoptosis is critical for proper development of the nervous system. Yet, little is known about molecules that regulate apoptosis of proliferative neurons. Here we identify a soluble, secreted form of CPG15 expressed in embryonic rat brain regions undergoing rapid proliferation and...

journal_title：Nature neuroscience

authors： Putz U,Harwell C,Nedivi E

更新日期：2005-03-01 00:00:00

abstract：:Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice el...

journal_title：Nature neuroscience

authors： Nott A,Cheng J,Gao F,Lin YT,Gjoneska E,Ko T,Minhas P,Zamudio AV,Meng J,Zhang F,Jin P,Tsai LH

更新日期：2016-11-01 00:00:00

abstract：:In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. We hypothesized that hypoxia involves a transition from neuronal mechanisms of normal breathing (eupnea) to a rudimentary pattern of inspiratory movements (gasping). We provide evidence for hypoxia-driven transformation w...

journal_title：Nature neuroscience

authors： Paton JF,Abdala AP,Koizumi H,Smith JC,St-John WM

更新日期：2006-03-01 00:00:00

abstract：:The hippocampus is often considered to be an important site for stress and learning interactions; however, it has never been demonstrated whether these effects require the hippocampus. In the current study, hippocampal lesions prevented both enhancements of learning after stress in male rats and impairments of learnin...

journal_title：Nature neuroscience

authors： Bangasser DA,Shors TJ

更新日期：2007-11-01 00:00:00

abstract：:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...

journal_title：Nature neuroscience

authors： Mameli M,Bellone C,Brown MT,Lüscher C

更新日期：2011-04-01 00:00:00

abstract：:Trafficking of AMPA receptors (AMPARs) is important for many forms of synaptic plasticity. However, the link between activity and resulting synaptic alterations is not fully understood. We identified a direct interaction between N-ethylmaleimide-sensitive fusion protein (NSF), an ATPase involved in membrane fusion eve...

journal_title：Nature neuroscience

authors： Evers DM,Matta JA,Hoe HS,Zarkowsky D,Lee SH,Isaac JT,Pak DT

更新日期：2010-10-01 00:00:00

abstract：:High and low spatial frequency information in visual images is processed by distinct neural channels. Using event-related functional magnetic resonance imaging (fMRI) in humans, we show dissociable roles of such visual channels for processing faces and emotional fearful expressions. Neural responses in fusiform cortex...

journal_title：Nature neuroscience

authors： Vuilleumier P,Armony JL,Driver J,Dolan RJ

更新日期：2003-06-01 00:00:00

abstract：:We argue that there will be no single (genetic or cognitive) cause for the diverse symptoms defining autism. We present recent evidence of behavioral fractionation of social impairment, communication difficulties and rigid and repetitive behaviors. Twin data suggest largely nonoverlapping genes acting on each of these...

journal_title：Nature neuroscience

authors： Happé F,Ronald A,Plomin R

更新日期：2006-10-01 00:00:00

abstract：:Previous work has shown that human adolescents may be hypersensitive to rewards, but it is not known which aspect of reward processing is responsible for this. We separated decision value and prediction error signals and found that neural prediction error signals in the striatum peaked in adolescence, whereas neural d...

journal_title：Nature neuroscience

authors： Cohen JR,Asarnow RF,Sabb FW,Bilder RM,Bookheimer SY,Knowlton BJ,Poldrack RA

更新日期：2010-06-01 00:00:00

abstract：:Population coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population size, as the global reward signal becomes less and less related to the performance of any single neuron...

journal_title：Nature neuroscience

authors： Urbanczik R,Senn W

更新日期：2009-03-01 00:00:00

abstract：:Information analysis shows that face-selective neurons in inferior temporal cortex encode different stimulus attributes early and late in their response to the same image. ...

journal_title：Nature neuroscience

authors： Oram MW,Richmond BJ

更新日期：1999-10-01 00:00:00

abstract：:Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penic...

journal_title：Nature neuroscience

authors： García-Alías G,Barkhuysen S,Buckle M,Fawcett JW

更新日期：2009-09-01 00:00:00

abstract：:Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss o...

journal_title：Nature neuroscience

authors： Knuckles P,Vogt MA,Lugert S,Milo M,Chong MM,Hautbergue GM,Wilson SA,Littman DR,Taylor V

更新日期：2012-06-17 00:00:00

abstract：:Electrophysiological connectivity patterns in cortex often have a few strong connections, which are sometimes bidirectional, among a lot of weak connections. To explain these connectivity patterns, we created a model of spike timing-dependent plasticity (STDP) in which synaptic changes depend on presynaptic spike arri...

journal_title：Nature neuroscience

authors： Clopath C,Büsing L,Vasilaki E,Gerstner W

更新日期：2010-03-01 00:00:00

abstract：:Neural stem and progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes and oligodendrocytes. However, the mechanisms underlying the decision of a stem cell to either self-renew or differentiate are incompletely understood. We demonstrate here that Fbw7 (F-box and WD repeat domain containing-7), the substrate re...

journal_title：Nature neuroscience

authors： Hoeck JD,Jandke A,Blake SM,Nye E,Spencer-Dene B,Brandner S,Behrens A

更新日期：2010-11-01 00:00:00

abstract：:Experience-dependent plasticity in adult visual cortex is believed to have important roles in visual coding and perceptual learning. Here we show that repeated stimulation with movies of natural scenes induces a rapid improvement in response reliability in cat visual cortex, whereas stimulation with white noise or fla...

journal_title：Nature neuroscience

authors： Yao H,Shi L,Han F,Gao H,Dan Y

更新日期：2007-06-01 00:00:00

abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...

journal_title：Nature neuroscience

authors： Matsumoto M,Hikosaka O

更新日期：2009-01-01 00:00:00

abstract：:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in sp...

journal_title：Nature neuroscience

authors： Ran C,Hoon MA,Chen X

更新日期：2016-09-01 00:00:00

abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...

journal_title：Nature neuroscience

authors： Prinz M,Priller J

更新日期：2017-02-01 00:00:00

abstract：:A fundamental assumption in neuroscience is that brain structure determines function. Accordingly, functionally distinct regions of cortex should be structurally distinct in their connections to other areas. We tested this hypothesis in relation to face selectivity in the fusiform gyrus. By using only structural conne...

journal_title：Nature neuroscience

authors： Saygin ZM,Osher DE,Koldewyn K,Reynolds G,Gabrieli JD,Saxe RR

更新日期：2011-12-25 00:00:00

abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...

journal_title：Nature neuroscience

authors： Beuming T,Kniazeff J,Bergmann ML,Shi L,Gracia L,Raniszewska K,Newman AH,Javitch JA,Weinstein H,Gether U,Loland CJ

更新日期：2008-07-01 00:00:00

abstract：:The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...

journal_title：Nature neuroscience

authors： Takahashi N,Ebner C,Sigl-Glöckner J,Moberg S,Nierwetberg S,Larkum ME

更新日期：2020-10-01 00:00:00

abstract：:Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...

journal_title：Nature neuroscience

authors： Mainland JD,Keller A,Li YR,Zhou T,Trimmer C,Snyder LL,Moberly AH,Adipietro KA,Liu WL,Zhuang H,Zhan S,Lee SS,Lin A,Matsunami H

更新日期：2014-01-01 00:00:00

abstract：:The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant wo...

journal_title：Nature neuroscience

authors： Liu J,Ward A,Gao J,Dong Y,Nishio N,Inada H,Kang L,Yu Y,Ma D,Xu T,Mori I,Xie Z,Xu XZ

更新日期：2010-06-01 00:00:00

abstract：:Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...

journal_title：Nature neuroscience

authors： Sreenivasan S,Fiete I

更新日期：2011-09-11 00:00:00

abstract：:Calcium arising through release from intracellular stores and from influx across the plasma membrane is essential for signalling by specific guidance cues and by factors that inhibit axon regeneration. The mediators of calcium influx in these cases are largely unknown. Transient receptor potential channels (TRPCs) bel...

journal_title：Nature neuroscience

authors： Shim S,Goh EL,Ge S,Sailor K,Yuan JP,Roderick HL,Bootman MD,Worley PF,Song H,Ming GL

更新日期：2005-06-01 00:00:00

abstract：:Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...

journal_title：Nature neuroscience

authors： Tian D,Stoppel LJ,Heynen AJ,Lindemann L,Jaeschke G,Mills AA,Bear MF

更新日期：2015-02-01 00:00:00

abstract：:A brief visual target stimulus may be rendered invisible if it is immediately preceded or followed by another stimulus. This class of illusions, known as visual masking, may allow insights into the neural mechanisms that underlie visual perception. We have therefore explored the temporal characteristics of masking ill...

journal_title：Nature neuroscience

authors： Macknik SL,Livingstone MS

更新日期：1998-06-01 00:00:00

abstract：:Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...

journal_title：Nature neuroscience

authors： Wu HG,Miyamoto YR,Gonzalez Castro LN,Ölveczky BP,Smith MA

更新日期：2014-02-01 00:00:00

abstract：:A long-standing debate in neuroscience is whether classical and operant conditioning are mechanistically similar or distinct. The feeding behavior of Aplysia provides a model system suitable for addressing this question. Here we report that classical and operant conditioning of feeding behavior differentially modify t...

journal_title：Nature neuroscience

authors： Lorenzetti FD,Mozzachiodi R,Baxter DA,Byrne JH

更新日期：2006-01-01 00:00:00