Abstract：
:The spinal cord is the initial stage that integrates temperature information from peripheral inputs. Here we used molecular genetics and in vivo calcium imaging to investigate the coding of cutaneous temperature in the spinal cord in mice. We found that heating or cooling the skin evoked robust calcium responses in spinal neurons, and their activation threshold temperatures distributed smoothly over the entire range of stimulation temperatures. Once activated, heat-responding neurons encoded the absolute skin temperature without adaptation and received major inputs from transient receptor potential (TRP) channel V1 (TRPV1)-positive dorsal root ganglion (DRG) neurons. By contrast, cold-responding neurons rapidly adapted to ambient temperature and selectively encoded temperature changes. These neurons received TRP channel M8 (TRPM8)-positive DRG inputs as well as novel TRPV1(+) DRG inputs that were selectively activated by intense cooling. Our results provide a comprehensive examination of the temperature representation in the spinal cord and reveal fundamental differences in the coding of heat and cold.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Ran C,Hoon MA,Chen Xdoi
10.1038/nn.4350subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1201-9issue
9eissn
1097-6256issn
1546-1726pii
nn.4350journal_volume
19pub_type
杂志文章abstract：:Trial-to-trial variability in the blood oxygen level-dependent (BOLD) response of functional magnetic resonance imaging has been shown to be relevant to human perception and behavior, but the sources of this variability remain unknown. We demonstrate that coherent spontaneous fluctuations in human brain activity accou...
journal_title：Nature neuroscience
pub_type： 临床试验,杂志文章
doi：10.1038/nn1616
更新日期：2006-01-01 00:00:00
abstract：:Most advances in addiction treatment to date have addressed the physical dependence and withdrawal that accompany addiction to some drugs of abuse. In contrast, it has proven more difficult to develop medications that effectively treat drug craving and relapse, the core features of addictive disorders. Current efforts...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn945
更新日期：2002-11-01 00:00:00
abstract：:The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.4475
更新日期：2017-02-01 00:00:00
abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0432-1
更新日期：2019-08-01 00:00:00
abstract：:Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known neurofilament-dependent slowing of axonal transport, combined with the prominent misaccumulation of neurofilaments in ALS, su...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/4553
更新日期：1999-01-01 00:00:00
abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4035
更新日期：2015-07-01 00:00:00
abstract：:Predatory hunting plays a fundamental role in animal survival. Little is known about the neural circuits that convert sensory cues into neural signals to drive this behavior. Here we identified an excitatory subcortical neural circuit from the superior colliculus to the zona incerta that triggers predatory hunting. Th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-019-0405-4
更新日期：2019-06-01 00:00:00
abstract：:Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopam...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1438
更新日期：2005-05-01 00:00:00
abstract：:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neuro...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/78800
更新日期：2000-09-01 00:00:00
abstract：:To define the role of the Raf serine/threonine kinases in nervous system development, we conditionally targeted B-Raf and C-Raf, two of the three known mammalian Raf homologs, using a mouse line expressing Cre recombinase driven by a nestin promoter. Targeting of B-Raf, but not C-Raf, markedly attenuated baseline phos...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1898
更新日期：2007-05-01 00:00:00
abstract：:The endocytosis of AMPA receptors is thought to be important in the expression of long-term depression (LTD) triggered by NMDA receptor activation. Although signaling pathways necessary for LTD induction have been identified, those responsible for the regulated internalization of AMPA receptors are unknown. Here we sh...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/81823
更新日期：2000-12-01 00:00:00
abstract：:En route to their target, pioneering motor growth cones repeatedly encounter choice points at which they make pathway decisions. In the zebrafish mutant unplugged, two of the three segmental motor axons make incorrect decisions at a somitic choice point. Using positional cloning, we show here that unplugged encodes a ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1350
更新日期：2004-12-01 00:00:00
abstract：:We report a systematic relationship between sound-frequency tuning and sensitivity to interaural time delays for neurons in the midbrain nucleus of the inferior colliculus; neurons with relatively low best frequencies (BFs) showed response peaks at long delays, whereas neurons with relatively high BFs showed response ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/86049
更新日期：2001-04-01 00:00:00
abstract：:The zona limitans intrathalamica (ZLI), a narrow compartment in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor sonic hedgehog (Shh). Because genetic disruption of Shh in mouse causes severe early developmental defects, this strategy has not been useful in identifying...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1338
更新日期：2004-11-01 00:00:00
abstract：:The brain transforms physical sensory stimuli into meaningful perceptions. In animals making choices about sensory stimuli, neuronal activity in successive cortical stages reflects a progression from sensation to decision. Feedforward and feedback pathways connecting cortical areas are critical for this transformation...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4356
更新日期：2016-09-01 00:00:00
abstract：:In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0323-x
更新日期：2019-03-01 00:00:00
abstract：:Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4617
更新日期：2017-09-01 00:00:00
abstract：:Dendritic spikes signal synaptic integration at remote apical dendritic sites in neocortical pyramidal neurons in vitro. Do dendritic spikes have a salient signaling role under in vivo conditions, where neocortical pyramidal neurons are bombarded with synaptic input? In the present study, levels of synaptic conductanc...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1305
更新日期：2004-09-01 00:00:00
abstract：:Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/79924
更新日期：2000-10-01 00:00:00
abstract：:Uncovering structural regularities and architectural topologies of cortical circuitry is vital for understanding neural computations. Recently, an experimentally constrained algorithm generated a dense network reconstruction of a ∼0.3-mm3 volume from juvenile rat somatosensory neocortex, comprising ∼31,000 cells and ∼...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4576
更新日期：2017-07-01 00:00:00
abstract：:Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/nn.3811
更新日期：2014-10-01 00:00:00
abstract：:Despite the importance of neuropeptide release, which is evoked by long bouts of action potential activity and which regulates behavior, peptidergic vesicle movement has not been examined in living nerve terminals. Previous in vitro studies have found that secretory vesicle motion at many sites of release is constitut...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1377
更新日期：2005-02-01 00:00:00
abstract：:Unifying principles of movement have emerged from the computational study of motor control. We review several of these principles and show how they apply to processes such as motor planning, control, estimation, prediction and learning. Our goal is to demonstrate how specific models emerging from the computational app...
journal_title：Nature neuroscience
pub_type： 杂志文章,评审
doi：10.1038/81497
更新日期：2000-11-01 00:00:00
abstract：:A central question in the study of human behavior is the origin of willed action. EEG recordings of surface brain activity from human subjects performing a self-initiated movement show that the subjective experience of wanting to move follows, rather than precedes, the 'readiness potential'--an electrophysiological ma...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1160
更新日期：2004-01-01 00:00:00
abstract：:Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown. Here we show that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems. Further, we...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3094
更新日期：2012-06-01 00:00:00
abstract：:The origin of brain mechanisms that support human language-whether these originated de novo in humans or evolved from a neural substrate that existed in a common ancestor-remains a controversial issue. Although the answer is not provided by the fossil record, it is possible to make inferences by studying living specie...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1741
更新日期：2006-08-01 00:00:00
abstract：:Quantifying behavior is crucial for many applications in neuroscience. Videography provides easy methods for the observation and recording of animal behavior in diverse settings, yet extracting particular aspects of a behavior for further analysis can be highly time consuming. In motor control studies, humans or other...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0209-y
更新日期：2018-09-01 00:00:00
abstract：:Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0119-z
更新日期：2018-05-01 00:00:00
abstract：:Cocaine is a widely abused substance with psychostimulant effects that are attributed to inhibition of the dopamine transporter (DAT). We present molecular models for DAT binding of cocaine and cocaine analogs constructed from the high-resolution structure of the bacterial transporter homolog LeuT. Our models suggest ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2146
更新日期：2008-07-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-019-0546-5
更新日期：2019-12-01 00:00:00
