I see a face-a happy face.

abstract：:An action may lead to either a reward or a punishment. Therefore, an appropriate action needs to be chosen on the basis of the values of both expected rewards and expected punishments. To understand the underlying neural mechanisms, we conditioned monkeys using a Pavlovian procedure with two distinct contexts: one in ...

journal_title：Nature neuroscience

authors： Matsumoto M,Hikosaka O

更新日期：2009-01-01 00:00:00

abstract：:The 'cognitive map' hypothesis proposes that brain builds a unified representation of the spatial environment to support memory and guide future action. Forty years of electrophysiological research in rodents suggest that cognitive maps are neurally instantiated by place, grid, border and head direction cells in the h...

journal_title：Nature neuroscience

authors： Epstein RA,Patai EZ,Julian JB,Spiers HJ

更新日期：2017-10-26 00:00:00

abstract：:Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...

journal_title：Nature neuroscience

authors： Ito I,Ong RC,Raman B,Stopfer M

更新日期：2008-10-01 00:00:00

abstract：:The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...

journal_title：Nature neuroscience

authors： Esteve P,Rueda-Carrasco J,Inés Mateo M,Martin-Bermejo MJ,Draffin J,Pereyra G,Sandonís Á,Crespo I,Moreno I,Aso E,Garcia-Esparcia P,Gomez-Tortosa E,Rábano A,Fortea J,Alcolea D,Lleo A,Heneka MT,Valpuesta JM,Esteban JA,

更新日期：2019-08-01 00:00:00

abstract：:We introduce a deceptively simple behavioral task that robustly identifies two qualitatively different groups within the general population. When presented with an isochronous train of random syllables, some listeners are compelled to align their own concurrent syllable production with the perceived rate, whereas othe...

journal_title：Nature neuroscience

authors： Assaneo MF,Ripollés P,Orpella J,Lin WM,de Diego-Balaguer R,Poeppel D

更新日期：2019-04-01 00:00:00

abstract：:We report two functional magnetic resonance imaging experiments showing enhanced responses in human middle superior temporal sulcus for angry relative to neutral prosody. This emotional enhancement was voice specific, unrelated to isolated acoustic amplitude or frequency cues in angry prosody, and distinct from any co...

journal_title：Nature neuroscience

authors： Grandjean D,Sander D,Pourtois G,Schwartz S,Seghier ML,Scherer KR,Vuilleumier P

更新日期：2005-02-01 00:00:00

abstract：:Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...

journal_title：Nature neuroscience

authors： Tellez LA,Han W,Zhang X,Ferreira TL,Perez IO,Shammah-Lagnado SJ,van den Pol AN,de Araujo IE

更新日期：2016-03-01 00:00:00

abstract：:We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to in...

journal_title：Nature neuroscience

authors： Jovanovic JN,Czernik AJ,Fienberg AA,Greengard P,Sihra TS

更新日期：2000-04-01 00:00:00

abstract：:Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and h...

journal_title：Nature neuroscience

authors： Mato S,Chevaleyre V,Robbe D,Pazos A,Castillo PE,Manzoni OJ

更新日期：2004-06-01 00:00:00

abstract：:Vesicular release of neurotransmitter is the universal output signal of neurons in the brain. It is generally believed that fast transmitter release is restricted to nerve terminals that contact postsynaptic cells in the gray matter. Here we show in the rat brain that the neurotransmitter glutamate is also released at...

journal_title：Nature neuroscience

authors： Kukley M,Capetillo-Zarate E,Dietrich D

更新日期：2007-03-01 00:00:00

abstract：:Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...

journal_title：Nature neuroscience

authors： Iadecola C,Zhang F,Niwa K,Eckman C,Turner SK,Fischer E,Younkin S,Borchelt DR,Hsiao KK,Carlson GA

更新日期：1999-02-01 00:00:00

abstract：:In the version of this article initially published, the traces in Fig. 1j and in Fig. 1k, right, were duplicated from the corresponding traces in Fig. 1c, bottom, and Fig. 1d, bottom right. The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature neuroscience

authors： Marek R,Jin J,Goode TD,Giustino TF,Wang Q,Acca GM,Holehonnur R,Ploski JE,Fitzgerald PJ,Lynagh T,Lynch JW,Maren S,Sah P

更新日期：2018-09-01 00:00:00

abstract：:Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...

journal_title：Nature neuroscience

authors： Trimarco A,Forese MG,Alfieri V,Lucente A,Brambilla P,Dina G,Pieragostino D,Sacchetta P,Urade Y,Boizet-Bonhoure B,Martinelli Boneschi F,Quattrini A,Taveggia C

更新日期：2014-12-01 00:00:00

abstract：:The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2-lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hy...

journal_title：Nature neuroscience

authors： Mameli M,Bellone C,Brown MT,Lüscher C

更新日期：2011-04-01 00:00:00

abstract：:Sharp wave-associated field oscillations (∼200 Hz) of the hippocampus, referred to as ripples, are believed to be important for consolidation of explicit memory. Little is known about how ripples are regulated by other brain regions. We found that the median raphe region (MnR) is important for regulating hippocampal r...

journal_title：Nature neuroscience

authors： Wang DV,Yau HJ,Broker CJ,Tsou JH,Bonci A,Ikemoto S

更新日期：2015-05-01 00:00:00

abstract：:Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...

journal_title：Nature neuroscience

authors： Jordan BA,Fernholz BD,Khatri L,Ziff EB

更新日期：2007-04-01 00:00:00

abstract：:In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...

journal_title：Nature neuroscience

authors： Wu CL,Xia S,Fu TF,Wang H,Chen YH,Leong D,Chiang AS,Tully T

更新日期：2007-12-01 00:00:00

abstract：:Individuals' risk attitudes are known to guide choices about uncertain options. However, in the presence of others' decisions, these choices can be swayed and manifest as riskier or safer behavior than one would express alone. To test the mechanisms underlying effective social 'nudges' in human decision-making, we use...

journal_title：Nature neuroscience

authors： Chung D,Christopoulos GI,King-Casas B,Ball SB,Chiu PH

更新日期：2015-06-01 00:00:00

abstract：:Emotions operate along the dimension of approach and aversion, and it is reasonable to assume that orienting behavior is intrinsically linked to emotionally involved processes such as preference decisions. Here we describe a gaze 'cascade effect' that was present when human observers were shown pairs of human faces an...

journal_title：Nature neuroscience

authors： Shimojo S,Simion C,Shimojo E,Scheier C

更新日期：2003-12-01 00:00:00

abstract：:Communication plays an integral role in human social dynamics and is impaired in several neurodevelopmental disorders. Mice are used to study the neurobiology of social behavior; however, the extent to which mouse vocalizations influence social dynamics has remained elusive because it is difficult to identify the voca...

journal_title：Nature neuroscience

authors： Sangiamo DT,Warren MR,Neunuebel JP

更新日期：2020-03-01 00:00:00

abstract：:The most critical attribute of human language is its unbounded combinatorial nature: smaller elements can be combined into larger structures on the basis of a grammatical system, resulting in a hierarchy of linguistic units, such as words, phrases and sentences. Mentally parsing and representing such structures, howev...

journal_title：Nature neuroscience

authors： Ding N,Melloni L,Zhang H,Tian X,Poeppel D

更新日期：2016-01-01 00:00:00

abstract：:The precise role of synchronous neuronal firing in signal encoding remains unclear. To examine what kinds of signals can be carried by synchrony, I reproduced a multilayer feedforward network of neurons in an in vitro slice preparation of rat cortex using an iterative procedure. When constant and time-varying frequenc...

journal_title：Nature neuroscience

authors： Reyes AD

更新日期：2003-06-01 00:00:00

abstract：:The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax...

journal_title：Nature neuroscience

authors： Fischer AJ,Reh TA

更新日期：2001-03-01 00:00:00

abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...

journal_title：Nature neuroscience

authors： Irvine EE,Vernon J,Giese KP

更新日期：2005-04-01 00:00:00

abstract：:In neocortical circuits, repetitively active neurons evoke unitary postsynaptic potentials (PSPs) whose peak amplitudes either increase (facilitate) or decrease (depress) progressively. To examine the basis for these different synaptic responses, we made simultaneous recordings from three classes of neurons in cortica...

journal_title：Nature neuroscience

authors： Reyes A,Lujan R,Rozov A,Burnashev N,Somogyi P,Sakmann B

更新日期：1998-08-01 00:00:00

abstract：:Exposures to cocaine and morphine produce similar adaptations in nucleus accumbens (NAc)-based behaviors, yet produce very different adaptations at NAc excitatory synapses. In an effort to explain this paradox, we found that both drugs induced NMDA receptor-containing, AMPA receptor-silent excitatory synapses, albeit ...

journal_title：Nature neuroscience

authors： Graziane NM,Sun S,Wright WJ,Jang D,Liu Z,Huang YH,Nestler EJ,Wang YT,Schlüter OM,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological ...

journal_title：Nature neuroscience

authors： Storkebaum E,Quaegebeur A,Vikkula M,Carmeliet P

更新日期：2011-10-26 00:00:00

abstract：:Nucleus HVc of the avian song system is a forebrain structure critical in song production, perception and learning. Here we show that most HVc neurons that respond to auditory stimuli under anesthesia show no responses to the same stimulus in the awake, unrestrained bird. This suppression of auditory responses in awak...

journal_title：Nature neuroscience

authors： Schmidt MF,Konishi M

更新日期：1998-10-01 00:00:00

abstract：:Continuous, predictable events and spontaneous events may coincide in the visual environment. For a continuously moving object, the brain compensates for delays in transmission between a retinal event and neural responses in higher visual areas. Here we show that it similarly compensated for other smoothly changing fe...

journal_title：Nature neuroscience

authors： Sheth BR,Nijhawan R,Shimojo S

更新日期：2000-05-01 00:00:00

abstract：:Neural progenitor cells in the developing neocortex change over time to produce different neurons, a phenomenon that is also observed in other regions of the nervous system. Mouse Numb (also known as m-numb) and Numbl (also known as numblike or Nbl) are redundant but essential in maintaining virtually all progenitor c...

journal_title：Nature neuroscience

authors： Petersen PH,Zou K,Krauss S,Zhong W

更新日期：2004-08-01 00:00:00