Abstract:
:Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs). Experiments suggested that this effect was due to an action of BMPs on an early-stage progenitor in the ORN lineage. Further analysis revealed that progenitors exposed to BMPs rapidly (< 2 h) lost MASH1, a transcription factor known to be required for the production of ORNs. This disappearance was due to proteolysis of existing MASH1 protein, but new gene expression was required to trigger it. The data suggest a novel mechanism of BMP action, whereby the induced degradation of an essential transcription factor results in premature termination of a neuronal lineage.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Shou J,Rim PC,Calof ALdoi
10.1038/7251subject
Has Abstractpub_date
1999-04-01 00:00:00pages
339-45issue
4eissn
1097-6256issn
1546-1726journal_volume
2pub_type
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更新日期:2001-12-01 00:00:00
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pub_type: 评论,杂志文章,评审
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更新日期:1999-10-01 00:00:00
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更新日期:2016-08-01 00:00:00
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