Abstract:
:An amendment to this paper has been published and can be accessed via a link at the top of the paper.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Farhan SMK,Howrigan DP,Abbott LE,Klim JR,Topp SD,Byrnes AE,Churchhouse C,Phatnani H,Smith BN,Rampersaud E,Wu G,Wuu J,Shatunov A,Iacoangeli A,Khleifat AA,Mordes DA,Ghosh S,ALSGENS Consortium.,FALS Consortium.,Projectdoi
10.1038/s41593-019-0570-5subject
Has Abstractpub_date
2020-02-01 00:00:00pages
295issue
2eissn
1097-6256issn
1546-1726pii
10.1038/s41593-019-0570-5journal_volume
23pub_type
已发布勘误abstract::Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3449
更新日期:2013-08-01 00:00:00
abstract::Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium-dependent regulation of the ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/5715
更新日期:1999-02-01 00:00:00
abstract::Aggression is a social behavior essential for securing resources and defending oneself and family. Thanks to its indispensable function in competition and thus survival, aggression exists widely across animal species, including humans. Classical works from Tinbergen and Lorenz concluded that instinctive behaviors incl...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/s41593-020-00715-2
更新日期:2020-11-01 00:00:00
abstract::Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct in...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4517
更新日期:2017-04-01 00:00:00
abstract::Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3419
更新日期:2013-07-01 00:00:00
abstract::What neural activity in motor cortex represents and how it controls ongoing movement remain unclear. Suggestions that cortex generates low-level muscle control are discredited by correlations with higher-level parameters of hand movement, but no coherent alternative exists. I argue that the view of low-level control i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/73964
更新日期:2000-04-01 00:00:00
abstract::Neocortical GABAergic neurons have diverse molecular, structural and electrophysiological features, but the functional correlates of this diversity are largely unknown. We found unique membrane potential dynamics of somatostatin-expressing (SOM) neurons in layer 2/3 of the primary somatosensory barrel cortex of awake ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3051
更新日期:2012-02-26 00:00:00
abstract::EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling fun...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3249
更新日期:2012-12-01 00:00:00
abstract::Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-017-0004-1
更新日期:2017-12-01 00:00:00
abstract::As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2931
更新日期:2011-10-02 00:00:00
abstract::EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1655
更新日期:2006-03-01 00:00:00
abstract::Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4224
更新日期:2016-03-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs), negative regulators of neural determination in the early embryo, were found to be potent inhibitors of neurogenesis in olfactory epithelium (OE) cultures. BMPs 2, 4 or 7 decreased the number of proliferating progenitor cells and blocked production of olfactory receptor neurons (ORNs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/7251
更新日期:1999-04-01 00:00:00
abstract::The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn892
更新日期:2002-08-01 00:00:00
abstract::Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated cells specific to the tissue in which they reside. This view has been challenged; for example, neural stem cells can generate cells that normally orig...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/79924
更新日期:2000-10-01 00:00:00
abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::Fast desensitization is an important regulatory mechanism of neuronal NMDA receptor function. Only recombinant NMDA receptors composed of NR1/NR2A exhibit a fast component of desensitization similar to neuronal NMDA receptors. Here we report that the fast desensitization of NR1/NR2A receptors is caused by ambient zinc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn0901-894
更新日期:2001-09-01 00:00:00
abstract::Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment de...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2647
更新日期:2010-10-01 00:00:00
abstract::Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plastici...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1586
更新日期:2005-12-01 00:00:00
abstract::The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a si...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4086
更新日期:2015-10-01 00:00:00
abstract::The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-020-0677-8
更新日期:2020-10-01 00:00:00
abstract::Neuroscientists increasingly analyze the joint activity of multineuron recordings to identify population-level structures believed to be significant and scientifically novel. Claims of significant population structure support hypotheses in many brain areas. However, these claims require first investigating the possibi...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4617
更新日期:2017-09-01 00:00:00
abstract::Entorhinal grid cells in mammals fire as a function of animal location, with spatially periodic response patterns. This nonlocal periodic representation of location, a local variable, is unlike other neural codes. There is no theoretical explanation for why such a code should exist. We examined how accurately the grid...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2901
更新日期:2011-09-11 00:00:00
abstract::In the version of this article initially published online, the accession code was given as GSE1000333. The correct code is GSE100033. The error has been corrected in the print, HTML and PDF versions of the article. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0114-4
更新日期:2018-07-01 00:00:00
abstract::The auditory system encodes sound by decomposing the amplitude signal arriving at the ear into multiple frequency bands whose center frequencies and bandwidths are approximately exponential functions of the distance from the stapes. This organization is thought to result from the adaptation of cochlear mechanisms to t...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn831
更新日期:2002-04-01 00:00:00
abstract::Learning to adapt to a complex and fluctuating environment requires the ability to adjust neural representations of sensory stimuli. Through pattern completion processes, cortical networks can reconstruct familiar patterns from degraded input patterns, whereas pattern separation processes allow discrimination of even ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2966
更新日期:2011-11-20 00:00:00
abstract::The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. The CNS-resident immune system is comprised mainly of innate immune cells and operates under homeostatic conditions. These m...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.4475
更新日期:2017-02-01 00:00:00
abstract::Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3911
更新日期:2015-02-01 00:00:00
abstract::Motor function requires that motor axons extend from the spinal cord at regular intervals and that they are myelinated by Schwann cells. Little attention has been given to another cellular structure, the perineurium, which ensheaths the motor nerve, forming a flexible, protective barrier. Consequently, the origin of p...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2025
更新日期:2008-02-01 00:00:00
abstract::Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2278
更新日期:2009-04-01 00:00:00