Abstract：
:EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly. In addition, given that EphBs signal through multiple mechanisms, it has been challenging to define which signaling functions of EphBs regulate particular developmental events. To address these issues, we engineered triple knock-in mice in which the kinase activity of three neuronally expressed EphBs can be rapidly, reversibly and specifically blocked. We found that the tyrosine kinase activity of EphBs was required for axon guidance in vivo. In contrast, EphB-mediated synaptogenesis occurred normally when the kinase activity of EphBs was inhibited, suggesting that EphBs mediate synapse development by an EphB tyrosine kinase-independent mechanism. Taken together, our data indicate that EphBs control axon guidance and synaptogenesis by distinct mechanisms and provide a new mouse model for dissecting EphB function in development and disease.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Soskis MJ,Ho HY,Bloodgood BL,Robichaux MA,Malik AN,Ataman B,Rubin AA,Zieg J,Zhang C,Shokat KM,Sharma N,Cowan CW,Greenberg MEdoi
10.1038/nn.3249subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1645-54issue
12eissn
1097-6256issn
1546-1726pii
nn.3249journal_volume
15pub_type
杂志文章abstract：:We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to in...
journal_title：Nature neuroscience
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更新日期：2000-04-01 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：1998-12-01 00:00:00
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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journal_title：Nature neuroscience
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更新日期：2006-06-01 00:00:00
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journal_title：Nature neuroscience
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doi：10.1038/nn.2940
更新日期：2011-10-30 00:00:00
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更新日期：2012-03-11 00:00:00
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journal_title：Nature neuroscience
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更新日期：2013-04-01 00:00:00
abstract：:Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
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更新日期：2017-12-01 00:00:00
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更新日期：2013-05-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章
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更新日期：2007-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/88414
更新日期：2001-06-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 评论,杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-10-01 00:00:00
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journal_title：Nature neuroscience
pub_type： 杂志文章,评审
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更新日期：2006-10-01 00:00:00
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更新日期：2017-11-01 00:00:00
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更新日期：2011-04-01 00:00:00
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更新日期：2019-06-01 00:00:00
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更新日期：2001-11-01 00:00:00
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更新日期：2015-11-01 00:00:00
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更新日期：2016-11-01 00:00:00
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更新日期：2008-10-01 00:00:00
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更新日期：2008-09-01 00:00:00
