Abstract:
:Lateral and medial parts of entorhinal cortex (EC) convey nonspatial 'what' and spatial 'where' information, respectively, into hippocampal CA1, via both the indirect EC layer 2→ hippocampal dentate gyrus→CA3→CA1 and the direct EC layer 3→CA1 paths. However, it remains elusive how the direct path transfers distinct information and contributes to hippocampal learning functions. Here we report that lateral EC projection neurons selectively form direct excitatory synapses onto a subpopulation of morphologically complex, calbindin-expressing pyramidal cells (PCs) in the dorsal CA1 (dCA1), while medial EC neurons uniformly innervate all dCA1 PCs. Optogenetically inactivating the distinct lateral EC-dCA1 connections or the postsynaptic dCA1 calbindin-expressing PC activity slows olfactory associative learning. Moreover, optetrode recordings reveal that dCA1 calbindin-expressing PCs develop more selective spiking responses to odor cues during learning. Thus, our results identify a direct lateral EC→dCA1 circuit that is required for olfactory associative learning.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Li Y,Xu J,Liu Y,Zhu J,Liu N,Zeng W,Huang N,Rasch MJ,Jiang H,Gu X,Li X,Luo M,Li C,Teng J,Chen J,Zeng S,Lin L,Zhang Xdoi
10.1038/nn.4517subject
Has Abstractpub_date
2017-04-01 00:00:00pages
559-570issue
4eissn
1097-6256issn
1546-1726pii
nn.4517journal_volume
20pub_type
杂志文章abstract::Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antago...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn769
更新日期:2001-12-01 00:00:00
abstract::Angelman syndrome (AS) is a severe neurological disorder characterized by mental retardation, motor dysfunction and epilepsy. We show that the molecular and cellular deficits of an AS mouse model can be rescued by introducing an additional mutation at the inhibitory phosphorylation site of alphaCaMKII. Moreover, these...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1845
更新日期:2007-03-01 00:00:00
abstract::Although much learning occurs through direct experience of errors, humans and other animals can learn from the errors of other individuals. The medial frontal cortex (MFC) processes self-generated errors, but the neuronal architecture and mechanisms underlying the monitoring of others' errors are poorly understood. Ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3180
更新日期:2012-09-01 00:00:00
abstract::A single neurotransmitter elicits diverse physiological responses through activation of multiple receptor subtypes and/or heterosynaptic interactions involving distinct synaptic targets. We found that a typical excitatory transmitter released from the climbing fiber (CF) in the cerebellar cortex not only excited Purki...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/75718
更新日期:2000-06-01 00:00:00
abstract::Cerebellar abnormalities, particularly in Right Crus I (RCrusI), are consistently reported in autism spectrum disorders (ASD). Although RCrusI is functionally connected with ASD-implicated circuits, the contribution of RCrusI dysfunction to ASD remains unclear. Here neuromodulation of RCrusI in neurotypical humans res...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-017-0004-1
更新日期:2017-12-01 00:00:00
abstract::Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation has been implicated in a wide range of diseases. Here we demonstrate that inactivation of the Fto gene, encoding a nucleic acid demethylase, impairs dopamine receptor type 2 (D2R) and type 3 (D3R) (collectively, 'D2-like recepto...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3449
更新日期:2013-08-01 00:00:00
abstract::The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer's disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β formation. We tested wh...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0432-1
更新日期:2019-08-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease whose causes are still poorly understood. To identify additional genetic risk factors, we assessed the role of de novo mutations in ALS by sequencing the exomes of 47 ALS patients and both of their unaffected parents (n = 141 exomes). We fo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3412
更新日期:2013-07-01 00:00:00
abstract::In the nose, odorants are detected on the cilia of olfactory sensory neurons (OSNs), where a cAMP-mediated signaling pathway transforms odor stimulation into electrical responses. Phosphodiesterase (PDE) activity in OSN cilia has long been thought to account for rapid response termination by degrading odor-induced cAM...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2289
更新日期:2009-04-01 00:00:00
abstract::Motion and stereoscopic depth are fundamental parameters of the structural analysis of visual scenes. Because they are defined by a difference in object position, either over time or across the eyes, a common neural machinery may be used for encoding these attributes. To examine this idea, we analyzed responses of bin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/87462
更新日期:2001-05-01 00:00:00
abstract::Striatal parvalbumin (PV) and cholinergic interneurons (CHIs) are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells have hindered direct assessment of their contribution to activity in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-019-0341-3
更新日期:2019-04-01 00:00:00
abstract::Many neural signaling receptors are regulated by endocytosis, but little is known about receptor insertion into the plasma membrane. Time-lapse imaging of the beta2 adrenergic receptor expressed in cultured rat hippocampal neurons, using pH-sensitive green fluorescent protein tagging and total internal reflection fluo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn1679
更新日期:2006-05-01 00:00:00
abstract::Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here we profiled global patterns of adenosine-to-inosine (A-to-I) ed...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/s41593-018-0287-x
更新日期:2019-01-01 00:00:00
abstract::In the version of this article initially published, what was originally described as 'conditioned place preference' in a two-chamber mouse experiment could be better described as 'conditioned place avoidance'. ...
journal_title:Nature neuroscience
pub_type: 已发布勘误
doi:10.1038/s41593-018-0323-x
更新日期:2019-03-01 00:00:00
abstract::The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses of the cholinergic system. After release into the synaptic cleft, ACh is rapidly degraded by acetylcholinesterase (AChE). We have identified a mutation in the ache gene of the zebrafish, which abolishes ACh hydrolysis in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn788
更新日期:2002-02-01 00:00:00
abstract::Myelinating cells, oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system produce an enormous amount of plasma membrane during the myelination process, making them particularly susceptible to disruptions of the secretory pathway. Endoplasmic reticulum stress, initiated by the accumulation of un...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.2273
更新日期:2009-04-01 00:00:00
abstract::Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor presen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2192
更新日期:2008-10-01 00:00:00
abstract::A hallmark of addiction is the loss of control over drug intake, which is seen in only a fraction of those exposed to stimulant drugs such as cocaine. The cellular mechanisms underlying vulnerability or resistance to compulsive drug use remain unknown. We found that individual variability in the development of highly ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3369
更新日期:2013-05-01 00:00:00
abstract::Leptin regulates energy balance. However, knowledge of the critical intracellular transducers of leptin signaling remains incomplete. We found that Rho-kinase 1 (ROCK1) regulates leptin action on body weight homeostasis by activating JAK2, an initial trigger of leptin receptor signaling. Leptin promoted the physical i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3207
更新日期:2012-10-01 00:00:00
abstract::We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3843
更新日期:2014-12-01 00:00:00
abstract::Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3729
更新日期:2014-07-01 00:00:00
abstract::Huntington's disease (HD) is caused by an expansion of exonic CAG triplet repeats in the gene encoding huntingtin protein (Htt), but the mechanisms by which this mutant protein causes neurodegeneration remain unknown. Here we show that lymphoblast mitochondria from patients with HD have a lower membrane potential and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn884
更新日期:2002-08-01 00:00:00
abstract::How different are the neuronal circuits for a given behavior across individual animals? To address this question, we measured multiple cellular and synaptic parameters in individual preparations to see how they correlated with circuit function, using neurons and synapses in the pyloric circuit of the stomatogastric ga...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2404
更新日期:2009-11-01 00:00:00
abstract::Understanding the origins and evolution of synapses may provide insight into species diversity and the organization of the brain. Using comparative proteomics and genomics, we examined the evolution of the postsynaptic density (PSD) and membrane-associated guanylate kinase (MAGUK)-associated signaling complexes (MASCs...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2135
更新日期:2008-07-01 00:00:00
abstract::Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.4224
更新日期:2016-03-01 00:00:00
abstract::During development and aging and in amblyopia, visual acuity is far below the limitations set by the retina. Expression of brain-derived neurotrophic factor (BDNF) in the visual cortex is reduced in these situations. We asked whether neurotrophic tyrosine kinase receptor, type 2 (TrkB) regulates cortical visual acuity...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.2534
更新日期:2010-05-01 00:00:00
abstract::Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3419
更新日期:2013-07-01 00:00:00
abstract::Rapid eye movement (REM) sleep has been considered important for consolidation of memories, particularly of skills. Contrary to expectations, we found that REM sleep suppression by administration of selective serotonin or norepinephrine re-uptake inhibitors after training did not impair consolidation of skills or word...
journal_title:Nature neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/nn.2206
更新日期:2009-04-01 00:00:00
abstract::In humans and many other animals, memory consolidation occurs through multiple temporal phases and usually involves more than one neuroanatomical brain system. Genetic dissection of Pavlovian olfactory learning in Drosophila melanogaster has revealed multiple memory phases, but the predominant view holds that all memo...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2005
更新日期:2007-12-01 00:00:00
abstract::The hippocampus is thought to be involved in episodic memory formation by reactivating traces of waking experience during sleep. Indeed, the joint firing of spatially tuned pyramidal cells encoding nearby places recur during sleep. We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places inc...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn2037
更新日期:2008-02-01 00:00:00