Abstract：
:Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neurons using dual whole-cell recordings. We found that dendritic EPSP amplitude increases with distance from the soma, counterbalancing the filtering effects of the dendrites and reducing the location dependence of somatic EPSP amplitude. Dendritic current injections and a multi-compartmental computer model demonstrated that dendritic membrane properties have only a minor role in elevating the local EPSP. Instead a progressive increase in synaptic conductance seems to be primarily responsible for normalizing the amplitudes of individual inputs.
journal_name
Nat Neuroscijournal_title
Nature neuroscienceauthors
Magee JC,Cook EPdoi
10.1038/78800subject
Has Abstractpub_date
2000-09-01 00:00:00pages
895-903issue
9eissn
1097-6256issn
1546-1726journal_volume
3pub_type
杂志文章abstract：:The endocytosis of AMPA receptors (AMPARs) underlies several forms of synaptic plasticity, including NMDA receptor (NMDAR)-dependent long-term depression (LTD), but the molecular mechanisms responsible for this trafficking remain unknown. We found that PSD-95, a major postsynaptic density protein, is important for NMD...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2249
更新日期：2009-02-01 00:00:00
abstract：:UTX is a chromatin modifier required for development and neural lineage specification, but how it controls these biological processes is unclear. To determine the molecular mechanisms of UTX, we identified novel UTX protein interaction partners. Here we show that UTX and 53BP1 directly interact and co-occupy promoters...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0328-5
更新日期：2019-03-01 00:00:00
abstract：:Independent evidence associates β-amyloid pathology with both non-rapid eye movement (NREM) sleep disruption and memory impairment in older adults. However, whether the influence of β-amyloid pathology on hippocampus-dependent memory is, in part, driven by impairments of NREM slow wave activity (SWA) and associated ov...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4035
更新日期：2015-07-01 00:00:00
abstract：:Studies of populations of receptor proteins suggest that their number and location are highly regulated. Single-particle tracking of glycine receptors now reveals the direct movement of receptors between different clusters of the anchoring protein gephyrin. ...
journal_title：Nature neuroscience
pub_type： 评论,杂志文章,评审
doi：10.1038/85042
更新日期：2001-03-01 00:00:00
abstract：:We investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat Ca(v)3.1 and Ca(v)3.3 channels without affecting the voltage dependence of activation or inactivation, wher...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1921
更新日期：2007-07-01 00:00:00
abstract：:Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3491
更新日期：2013-10-01 00:00:00
abstract：:Amyloid plaques are a hallmark of Alzheimer disease, but their importance in its pathogenesis is controversial. By neuronal labeling and transcranial two-photon imaging, we show in a transgenic mouse model of Alzheimer disease that dendrites passing through or near fibrillar amyloid deposits undergo spine loss and sha...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1335
更新日期：2004-11-01 00:00:00
abstract：:Several ion channels are thought to be directly modulated by nitric oxide (NO), but the molecular basis of this regulation is unclear. Here we show that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO. Site-directed mutagenesis identified a critical cys...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/71090
更新日期：2000-01-01 00:00:00
abstract：:Autophosphorylation of alpha calcium-calmodulin-dependent kinase II (alphaCaMKII) has been proposed to be the key event in memory storage. We tested this hypothesis with autophosphorylation-deficient mutant mice in hippocampus- and amygdala-dependent learning and memory tasks and found that the autophosphorylation of ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1431
更新日期：2005-04-01 00:00:00
abstract：:As the neural network becomes wired, postsynaptic signaling molecules are thought to control the growth of dendrites and synapses. However, how these molecules are coordinated to sculpt postsynaptic structures is less well understood. We find that ephrin-B3, a transmembrane ligand for Eph receptors, functions postsyna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2931
更新日期：2011-10-02 00:00:00
abstract：:Despite the importance of neuropeptide release, which is evoked by long bouts of action potential activity and which regulates behavior, peptidergic vesicle movement has not been examined in living nerve terminals. Previous in vitro studies have found that secretory vesicle motion at many sites of release is constitut...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1377
更新日期：2005-02-01 00:00:00
abstract：:Though motor neurons selectively degenerate in amyotrophic lateral sclerosis, other cell types are likely involved in this disease. We recently generated rNLS8 mice in which human TDP-43 (hTDP-43) pathology could be reversibly induced in neurons and expected that microglia would contribute to neurodegeneration. Howeve...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/s41593-018-0083-7
更新日期：2018-03-01 00:00:00
abstract：:Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4289
更新日期：2016-06-01 00:00:00
abstract：:It is widely believed that attention selects locations at an earlier stage than it selects nonspatial features, but this has been tested only under conditions of minimal competition. We found that, when competition was increased, color-based attention was able to influence the feedforward flow of information in humans...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2223
更新日期：2009-01-01 00:00:00
abstract：:The ability to attribute mental states to others, and therefore to predict others' behavior, is particularly advanced in humans. A controversial but untested idea is that this is achieved by simulating the other person's mental processes in one's own mind. If this is the case, then the same neural systems activated by...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1168
更新日期：2004-01-01 00:00:00
abstract：:Intrinsic signal imaging from inferotemporal (IT) cortex, a visual area essential for object perception and recognition, revealed that visually presented objects activated patches in a distributed manner. When visual features of these objects were partially removed, the simplified stimuli activated only a subset of th...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/90547
更新日期：2001-08-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of con...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1718
更新日期：2006-07-01 00:00:00
abstract：:The olfactory system faces a hard problem: on the basis of noisy information from olfactory receptor neurons (the neurons that transduce chemicals to neural activity), it must figure out which odors are present in the world. Odors almost never occur in isolation, and different odors excite overlapping populations of o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.4444
更新日期：2017-01-01 00:00:00
abstract：:Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3717
更新日期：2014-06-01 00:00:00
abstract：:Projection neurons migrate from the ventricular zone to the neocortical plate during the development of the mouse brain. Their overall movement is radial, but they become multipolar and move nonradially in the intermediate zone. Here we show that Reelin, the Rap1 GTPase and N-cadherin (NCad) are important for multipol...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2816
更新日期：2011-06-01 00:00:00
abstract：:Evaluating social others requires processing complex information. Nevertheless, we can rapidly form an opinion of an individual during an initial encounter. Moreover, people can vary in these opinions, even though the same information is provided. We investigated the brain mechanisms that give rise to the impressions ...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.2278
更新日期：2009-04-01 00:00:00
abstract：:In the published version of this article, a data point is missing from Fig. 4f, and the y-axis label reads "RFpre"; it should read "RFpref." The original article has not been corrected. The original and corrected figures are shown in the accompanying Publisher Correction. ...
journal_title：Nature neuroscience
pub_type： 已发布勘误
doi：10.1038/s41593-018-0181-6
更新日期：2018-09-01 00:00:00
abstract：:Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons, yet our knowledge of synaptic processing in these dendrites has been hampered by their inaccessibility for electrical recordings. A new approach to patch-clamp recordings enabled us to characterize the integrative properties o...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1826
更新日期：2007-02-01 00:00:00
abstract：:In mammals, many daily cycles are driven by a central circadian clock, which is based on the cell-autonomous rhythmic expression of clock genes. It is not clear, however, how peripheral cells are able to interpret the rhythmic signals disseminated from this central oscillator. Here we show that cycling expression of t...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn806
更新日期：2002-03-01 00:00:00
abstract：:The painful sensations produced by a laceration, freeze, burn, muscle strain or internal injury are readily distinguishable because each is characterized by a particular sensory quality such as sharp, aching, burning or prickling. We propose that there are specific neural correlates of each pain quality, and here we u...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn955
更新日期：2002-11-01 00:00:00
abstract：:Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3669
更新日期：2014-04-01 00:00:00
abstract：:Long-term potentiation (LTP) is thought to be critically involved not only in learning and memory, but also during the activity-dependent developmental phases of neural circuit formation and refinement. Whether the mechanisms underlying LTP change during this phase of postnatal development, however, is unknown. We rep...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn985
更新日期：2003-01-01 00:00:00
abstract：:Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn1867
更新日期：2007-04-01 00:00:00
abstract：:Grid cells in layer II of the medial entorhinal cortex form a principal component of the mammalian neural representation of space. The firing pattern of a single grid cell has been hypothesized to be generated through attractor dynamics in a network with a specific local connectivity including both excitatory and inhi...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3310
更新日期：2013-03-01 00:00:00
abstract：:Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...
journal_title：Nature neuroscience
pub_type： 杂志文章
doi：10.1038/nn.3601
更新日期：2014-01-01 00:00:00
